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MLN-3897 , CAS No.M611957, Antagonist of CCR1;Antagonist of CCR5

  • Moligand™
Item Number
M611957
Grouped product items
SKUSizeAvailabilityPrice Qty
M611957-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,300.90
M611957-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,000.90
View related series
CCR1 Antagonist CCR5 Antagonist

Basic Description

SynonymsAVE-9897;AVE9897;MLN3897
GradeMoligand™
Action TypeANTAGONIST
Mechanism of actionAntagonist of CCR1;Antagonist of CCR5

Associated Targets

CCR5 Tclin C-C chemokine receptor type 5 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CCR1 Tchem C-C chemokine receptor type 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

INCHI InChI=1S/C32H37ClN2O3/c1-30(2)21-35(18-15-32(30,37)22-9-12-24(33)13-10-22)17-6-8-25-26-7-5-16-34-28(26)20-38-29-14-11-23(19-27(25)29)31(3,4)36/h5,7-14,16,19,36-37H,6,15,17-18,20-21H2,1-4H3/b25-8+
InChi Key ZGFJFBOLVLFLLN-ZNLRHDTNSA-N
Canonical SMILES Clc1ccc(cc1)C1(O)CCN(CC1(C)C)CC/C=C\1/c2cc(ccc2OCc2c1cccn2)C(O)(C)C
Isomeric SMILES CC1(CN(CCC1(C2=CC=C(C=C2)Cl)O)CC/C=C/3\C4=C(COC5=C3C=C(C=C5)C(C)(C)O)N=CC=C4)C
PubChem CID 18437138

Certificates

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Related Documents

References

1. Vallet S, Raje N, Ishitsuka K, Hideshima T, Podar K, Chhetri S, Pozzi S, Breitkreutz I, Kiziltepe T, Yasui H et al..  (2007)  MLN3897, a novel CCR1 inhibitor, impairs osteoclastogenesis and inhibits the interaction of multiple myeloma cells and osteoclasts..  Blood,  110  (10): (3744-52).  [PMID:17715391]
2. Vergunst CE, Gerlag DM, von Moltke L, Karol M, Wyant T, Chi X, Matzkin E, Leach T, Tak PP.  (2009)  MLN3897 plus methotrexate in patients with rheumatoid arthritis: safety, efficacy, pharmacokinetics, and pharmacodynamics of an oral CCR1 antagonist in a phase IIa, double-blind, placebo-controlled, randomized, proof-of-concept study..  Arthritis Rheum,  60  (12): (3572-81).  [PMID:19950299]
3. Pusalkar S, Plesescu M, Milton M, Balani SK, Chowdhury S, Prakash S.  (2016)  Metabolism, Excretion and Pharmacokinetics of MLN3897, a CCR1 Antagonist, in Humans..  Drug Metab Lett,  10  (1): (22-37).  [PMID:26031460]

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