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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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M611957-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,300.90 | |
M611957-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,000.90 |
Synonyms | AVE-9897;AVE9897;MLN3897 |
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Grade | Moligand™ |
Action Type | ANTAGONIST |
Mechanism of action | Antagonist of CCR1;Antagonist of CCR5 |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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INCHI | InChI=1S/C32H37ClN2O3/c1-30(2)21-35(18-15-32(30,37)22-9-12-24(33)13-10-22)17-6-8-25-26-7-5-16-34-28(26)20-38-29-14-11-23(19-27(25)29)31(3,4)36/h5,7-14,16,19,36-37H,6,15,17-18,20-21H2,1-4H3/b25-8+ |
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InChi Key | ZGFJFBOLVLFLLN-ZNLRHDTNSA-N |
Canonical SMILES | Clc1ccc(cc1)C1(O)CCN(CC1(C)C)CC/C=C\1/c2cc(ccc2OCc2c1cccn2)C(O)(C)C |
Isomeric SMILES | CC1(CN(CCC1(C2=CC=C(C=C2)Cl)O)CC/C=C/3\C4=C(COC5=C3C=C(C=C5)C(C)(C)O)N=CC=C4)C |
PubChem CID | 18437138 |
Enter Lot Number to search for COA:
1. Vallet S, Raje N, Ishitsuka K, Hideshima T, Podar K, Chhetri S, Pozzi S, Breitkreutz I, Kiziltepe T, Yasui H et al.. (2007) MLN3897, a novel CCR1 inhibitor, impairs osteoclastogenesis and inhibits the interaction of multiple myeloma cells and osteoclasts.. Blood, 110 (10): (3744-52). [PMID:17715391] |
2. Vergunst CE, Gerlag DM, von Moltke L, Karol M, Wyant T, Chi X, Matzkin E, Leach T, Tak PP. (2009) MLN3897 plus methotrexate in patients with rheumatoid arthritis: safety, efficacy, pharmacokinetics, and pharmacodynamics of an oral CCR1 antagonist in a phase IIa, double-blind, placebo-controlled, randomized, proof-of-concept study.. Arthritis Rheum, 60 (12): (3572-81). [PMID:19950299] |
3. Pusalkar S, Plesescu M, Milton M, Balani SK, Chowdhury S, Prakash S. (2016) Metabolism, Excretion and Pharmacokinetics of MLN3897, a CCR1 Antagonist, in Humans.. Drug Metab Lett, 10 (1): (22-37). [PMID:26031460] |