ML120B is a potent inhibitor of IKK-2 (IC50 = 60 nM). ML120B is orally bioavailable, and inhibits paw swelling, bone and cartilage degradation, and weight loss in rat adjuvant-induced arthritis.
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of inhibitor of nuclear factor kappa B kinase subunit beta
Product Description
MLN120B is a potent and effective IKKbeta inhibitor.
Associated Targets
C15orf56Tdark Putative uncharacterized protein C15orf56 0 Activities
1.Nagashima K, Sasseville VG, Wen D, Bielecki A, Yang H, Simpson C, Grant E, Hepperle M, Harriman G, Jaffee B et al.. (2006) Rapid TNFR1-dependent lymphocyte depletion in vivo with a selective chemical inhibitor of IKKbeta.. Blood, 107 (11):(4266-73). [PMID:16439676]
2.Wen D, Nong Y, Morgan JG, Gangurde P, Bielecki A, Dasilva J, Keaveney M, Cheng H, Fraser C, Schopf L et al.. (2006) A selective small molecule IkappaB Kinase beta inhibitor blocks nuclear factor kappaB-mediated inflammatory responses in human fibroblast-like synoviocytes, chondrocytes, and mast cells.. J Pharmacol Exp Ther, 317 (3):(989-1001). [PMID:16525037]
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A2206049