G protein-biased D2receptor partial agonist (Ki= 1.2μM). Stimulates D2receptor G protein-mediated signaling and acts as an antagonist of dopamine-mediatedβ-arrestin recruitment at D2receptors.
MLS1547 is a highly efficacious D2 dopamine receptor (D2R) G p
1.Free RB, Chun LS, Moritz AE, Miller BN, Doyle TB, Conroy JL, Padron A, Meade JA, Xiao J, Hu X et al.. (2014) Discovery and characterization of a G protein-biased agonist that inhibits β-arrestin recruitment to the D2 dopamine receptor.. Mol Pharmacol, 86 (1):(96-105). [PMID:24755247]
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