MLT-748 - 99%, high purity , CAS No.1832578-30-9

Item Number

M414254

Grouped product items
SKU	Size	Availability	Price
M414254-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$93.90
M414254-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$282.90
M414254-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$456.90
M414254-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$699.90

MALT Inhibitors

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Basic Description

Specifications & Purity	99%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Information MLT-748 MLT-748 is a potent, selective and allosteric inhibitor of MALT1 with IC50 of 5 nM, binding at the interface between the caspase and immunoglobulin (Ig3) domains by displacing Trp580 and locking the catalytic site in an inactive state. Targets MALT1 (Cell-free assay) 5 nM In vitro MLT-748 binds MALT1 in the allosteric Trp580 pocket. MLT-748 binds and stabilizes mutant MALT1-W580S. Cleavage of MALT1 substrates is blocked by MLT-748 in B and T cells. MLT-748 rescues MALT1 function in patient MALT1^mut/mut lymphocytes. Cell Research(from reference) Cell lines：Immortalized B cells, human PBMCs, primary human CD3+ T cells, primary CD4+ lymphocytes Concentrations：2 μM Incubation Time：24 h

Names and Identifiers

IUPAC Name	1-[2-chloro-7-[(1R,2R)-1,2-dimethoxypropyl]pyrazolo[1,5-a]pyrimidin-6-yl]-3-[5-chloro-6-(triazol-2-yl)pyridin-3-yl]urea
INCHI	InChI=1S/C19H19Cl2N9O3/c1-10(32-2)17(33-3)16-13(9-22-15-7-14(21)28-29(15)16)27-19(31)26-11-6-12(20)18(23-8-11)30-24-4-5-25-30/h4-10,17H,1-3H3,(H2,26,27,31)/t10-,17+/m1/s1
InChi Key	XKQLNDPUQSZBJW-QGHHPUGFSA-N
Canonical SMILES	CC(C(C1=C(C=NC2=CC(=NN21)Cl)NC(=O)NC3=CC(=C(N=C3)N4N=CC=N4)Cl)OC)OC
PubChem CID	129072285
Molecular Weight	492.32

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8 results found

Lot Number	Certificate Type	Date	Item
G2416447	Certificate of Analysis	Mar 25, 2024	M414254
G2416462	Certificate of Analysis	Mar 25, 2024	M414254
G2416475	Certificate of Analysis	Mar 25, 2024	M414254
G2416490	Certificate of Analysis	Mar 25, 2024	M414254
G2416492	Certificate of Analysis	Mar 25, 2024	M414254
G2416493	Certificate of Analysis	Mar 25, 2024	M414254
G2416494	Certificate of Analysis	Mar 25, 2024	M414254
G2416495	Certificate of Analysis	Mar 25, 2024	M414254

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Basic Description