MMP-9 inhibitor - ≥95%, high purity , CAS No.1177749-58-4

  • ≥95%
Item Number
M274731
Grouped product items
SKUSizeAvailabilityPrice Qty
M274731-500μg
500μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$475.90

Basic Description

Specifications & Purity≥95%
Biochemical and Physiological MechanismsMMP-9 inhibitor. Role in tumor cell migration, invasion and angiogenesis
Storage TempStore at -20°C,Desiccated
Shipped InIce chest + Ice pads
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Associated Targets(Human)

MMP13 Tchem Collagenase 3 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MMP9 Tchem Matrix metalloproteinase-9 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MMP1 Tchem Matrix metalloproteinase-1 (7046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Mmp13 Matrix metalloproteinase 13 (19 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Adam17 ADAM17 (14 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mmp9 Matrix metalloproteinase 9 (38 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 2-[benzyl-(4-methoxyphenyl)sulfonylamino]-5-(diethylaminomethyl)-N-hydroxy-3-methylbenzamide
INCHI InChI=1S/C27H33N3O5S/c1-5-29(6-2)18-22-16-20(3)26(25(17-22)27(31)28-32)30(19-21-10-8-7-9-11-21)36(33,34)24-14-12-23(35-4)13-15-24/h7-17,32H,5-6,18-19H2,1-4H3,(H,28,31)
InChi Key WRNMBFWQBKEBIX-UHFFFAOYSA-N
Canonical SMILES CCN(CC)CC1=CC(=C(C(=C1)C)N(CC2=CC=CC=C2)S(=O)(=O)C3=CC=C(C=C3)OC)C(=O)NO
Isomeric SMILES CCN(CC)CC1=CC(=C(C(=C1)C)N(CC2=CC=CC=C2)S(=O)(=O)C3=CC=C(C=C3)OC)C(=O)NO
PubChem CID 21310926
Molecular Weight 511.63

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySoluble in DMSO to 10 mM

Related Documents

References

1. Tanaka T et al..  (2019)  Association of matrix metalloproteinase-9 and decorin expression with the infiltration of cervical cancer..  Oncol Lett,  17  (1306-1312).  [PMID:30655899]
2. Amara S et al..  (2017)  Critical role of SIK3 in mediating high salt and IL-17 synergy leading to breast cancer cell proliferation..  PLoS One,  12  (6): (e0180097).  [PMID:28658303]
3. Zhang D et al..  (2020)  Crocin alleviates lipopolysaccharide-induced acute respiratory distress syndrome by protecting against glycocalyx damage and suppressing inflammatory signaling pathways..  Inflamm Res,  69  (3): (267-278).  [PMID:31925528]
4. Ghasemi A et al..  (2019)  Estrogen-independent role of ERa in ovarian cancer progression induced by leptin/Ob-Rb axis..  Mol Cell Biochem,  458  (1-2): (207-217).  [PMID:31077012]
5. Jouida A et al..  (2022)  Exosomes from EGFR-Mutated Adenocarcinoma Induce a Hybrid EMT and MMP9-Dependant Tumor Invasion..  Cancers (Basel),  14  (15):   [PMID:35954442]
6. Carroll MJ et al..  (2016)  M2 macrophages induce ovarian cancer cell proliferation via a heparin binding epidermal growth factor/matrix metalloproteinase 9 intercellular feedback loop..  Oncotarget,  (52): (86608-86620).  [PMID:27888810]
7. Gao Q et al..  (2015)  Matrix metalloproteinase 9 secreted by hypoxia cardiac fibroblasts triggers cardiac stem cell migration in vitro..  Stem Cells Int,  2015  (836390).  [PMID:25767513]
8. Zhang Y et al..  (2015)  Matrix metalloproteinase-9 expression is enhanced in renal parietal epithelial cells of zucker diabetic Fatty rats and is induced by albumin in in vitro primary parietal cell culture..  PLoS One,  10  (4): (e0123276).  [PMID:25849723]
9. Ma YV et al..  (2018)  Mechanically stimulated osteocytes reduce the bone-metastatic potential of breast cancer cells in vitro by signaling through endothelial cells..  J Cell Biochem,      [PMID:30417549]
10. Su MT et al..  (2016)  miR-346 and miR-582-3p-regulated EG-VEGF expression and trophoblast invasion via matrix metalloproteinases 2 and 9..  Biofactors,      [PMID:27619846]
11. Wang JR et al..  (2014)  Orphan nuclear receptor Nur77 promotes colorectal cancer invasion and metastasis by regulating MMP-9 and E-cadherin..  Carcinogenesis,  35  (11): (2474-84).  [PMID:25064356]
12. Seang S et al..  (2019)  Prostacyclin Analog Promotes Human Dental Pulp Cell Migration via a Matrix Metalloproteinase 9-related Pathway..  J Endod,  45  (7): (873-881).  [PMID:31109753]
13. Wang X et al..  (2018)  Stimuli-Responsive Nanodiamond-Based Biosensor for Enhanced Metastatic Tumor Site Detection..  SLAS Technol,  23  (44-56).  [PMID:29020497]
14. Boukhedouni N et al..  (2020)  Type-1 cytokines regulate MMP-9 production and E-cadherin disruption to promote melanocyte loss in vitiligo..  JCI Insight,  (11):   [PMID:32369451]
15. Sun C et al..  (2017)  Up-Regulated Expression of Matrix Metalloproteinases in Endothelial Cells Mediates Platelet Microvesicle-Induced Angiogenesis..  Cell Physiol Biochem,  41  (6): (2319-2332).  [PMID:28463834]

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