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MMP-9 inhibitor - ≥95%, high purity , CAS No.1177749-58-4

  • ≥95%
Item Number
M274731
Grouped product items
SKUSizeAvailabilityPrice Qty
M274731-500μg
500μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$475.90
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Basic Description

Synonyms2-(N-Benzyl-4-methoxyphenylsulfonamido)-5-((diethylamino)methyl)-N-hydroxy-3-methylbenzamide
Specifications & Purity≥95%
Storage TempStore at -20°C,Desiccated
Shipped InDry ice
Product Description

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Associated Targets

MMP13 Tchem Collagenase 3 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MMP9 Tchem Matrix metalloproteinase-9 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 2-[benzyl-(4-methoxyphenyl)sulfonylamino]-5-(diethylaminomethyl)-N-hydroxy-3-methylbenzamide
INCHI InChI=1S/C27H33N3O5S/c1-5-29(6-2)18-22-16-20(3)26(25(17-22)27(31)28-32)30(19-21-10-8-7-9-11-21)36(33,34)24-14-12-23(35-4)13-15-24/h7-17,32H,5-6,18-19H2,1-4H3,(H,28,31)
InChi Key WRNMBFWQBKEBIX-UHFFFAOYSA-N
Canonical SMILES CCN(CC)CC1=CC(=C(C(=C1)C)N(CC2=CC=CC=C2)S(=O)(=O)C3=CC=C(C=C3)OC)C(=O)NO
Isomeric SMILES CCN(CC)CC1=CC(=C(C(=C1)C)N(CC2=CC=CC=C2)S(=O)(=O)C3=CC=C(C=C3)OC)C(=O)NO
PubChem CID 21310926
Molecular Weight 511.63

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySoluble in DMSO to 10 mM

Related Documents

 SDS

 Specification Sheet

References

1. Tanaka T et al..  (2019)  Association of matrix metalloproteinase-9 and decorin expression with the infiltration of cervical cancer..  Oncol Lett,  17  (1306-1312).  [PMID:30655899]
2. Amara S et al..  (2017)  Critical role of SIK3 in mediating high salt and IL-17 synergy leading to breast cancer cell proliferation..  PLoS One,  12  (6): (e0180097).  [PMID:28658303]
3. Zhang D et al..  (2020)  Crocin alleviates lipopolysaccharide-induced acute respiratory distress syndrome by protecting against glycocalyx damage and suppressing inflammatory signaling pathways..  Inflamm Res,  69  (3): (267-278).  [PMID:31925528]
4. Ghasemi A et al..  (2019)  Estrogen-independent role of ERa in ovarian cancer progression induced by leptin/Ob-Rb axis..  Mol Cell Biochem,  458  (1-2): (207-217).  [PMID:31077012]
5. Jouida A et al..  (2022)  Exosomes from EGFR-Mutated Adenocarcinoma Induce a Hybrid EMT and MMP9-Dependant Tumor Invasion..  Cancers (Basel),  14  (15):   [PMID:35954442]
6. Carroll MJ et al..  (2016)  M2 macrophages induce ovarian cancer cell proliferation via a heparin binding epidermal growth factor/matrix metalloproteinase 9 intercellular feedback loop..  Oncotarget,  7  (52): (86608-86620).  [PMID:27888810]
7. Gao Q et al..  (2015)  Matrix metalloproteinase 9 secreted by hypoxia cardiac fibroblasts triggers cardiac stem cell migration in vitro..  Stem Cells Int,  2015  (836390).  [PMID:25767513]
8. Zhang Y et al..  (2015)  Matrix metalloproteinase-9 expression is enhanced in renal parietal epithelial cells of zucker diabetic Fatty rats and is induced by albumin in in vitro primary parietal cell culture..  PLoS One,  10  (4): (e0123276).  [PMID:25849723]
9. Ma YV et al..  (2018)  Mechanically stimulated osteocytes reduce the bone-metastatic potential of breast cancer cells in vitro by signaling through endothelial cells..  J Cell Biochem,      [PMID:30417549]
10. Su MT et al..  (2016)  miR-346 and miR-582-3p-regulated EG-VEGF expression and trophoblast invasion via matrix metalloproteinases 2 and 9..  Biofactors,      [PMID:27619846]
11. Wang JR et al..  (2014)  Orphan nuclear receptor Nur77 promotes colorectal cancer invasion and metastasis by regulating MMP-9 and E-cadherin..  Carcinogenesis,  35  (11): (2474-84).  [PMID:25064356]
12. Seang S et al..  (2019)  Prostacyclin Analog Promotes Human Dental Pulp Cell Migration via a Matrix Metalloproteinase 9-related Pathway..  J Endod,  45  (7): (873-881).  [PMID:31109753]
13. Wang X et al..  (2018)  Stimuli-Responsive Nanodiamond-Based Biosensor for Enhanced Metastatic Tumor Site Detection..  SLAS Technol,  23  (44-56).  [PMID:29020497]
14. Boukhedouni N et al..  (2020)  Type-1 cytokines regulate MMP-9 production and E-cadherin disruption to promote melanocyte loss in vitiligo..  JCI Insight,  5  (11):   [PMID:32369451]
15. Sun C et al..  (2017)  Up-Regulated Expression of Matrix Metalloproteinases in Endothelial Cells Mediates Platelet Microvesicle-Induced Angiogenesis..  Cell Physiol Biochem,  41  (6): (2319-2332).  [PMID:28463834]

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