| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| M655150-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $104.90 |
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor, with an IC 50 and a K d of 145 nM and 12 nM for Mps1 and a K d of 61 nM for Plk1 . In Vitro Mps1-IN-2 is a potent, selective and ATP-competitive Mps1 kinase inhibitor, with an IC 50 and a K d of 145 nM and 12 nM. Mps1-IN-2 also shows high affinity for PLK1 and GAK with K d s of 61 and 140 nM, respectively, but shows little or no inhibition on other 352 member kinases. Mps1-IN-2 can induces bypass of a checkpoint-mediated mitotic arrest in U2OS cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:Mps1 12 nM (Kd) GAK 140 nM (Kd) PLK1 61 nM (Kd) PLK3 1600 nM (Kd) PLK4 3100 nM (Kd) STK33 5000 nM (Kd) |
| Canonical SMILES | CCOC1=C(C=CC(=C1)N2CCC(CC2)O)NC3=NC=C4C(=N3)N(CCC(=O)N4C)C5CCCC5 |
|---|---|
| Molecular Weight | 480.60 |
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