| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| M654799-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $142.90 |
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Biochemical and Physiological Mechanisms | Mps1-IN-3 is a potent and selective MPS1 kinase inhibitor, with an IC 50 of 50 nM. |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | Mps1-IN-3 is a potent and selective MPS1 kinase inhibitor, with an IC 50 of 50 nM. In Vitro Mps1-IN-3 is a potent MPS1 kinase inhibitor, with an IC 50 of 50 nM. Mps1-IN-3 inhibits the proliferation of U251 glioblastoma cells with an IC 50 of appr 5 µM. Mps1-IN-3 (2 μM) can completely abrogates checkpoint. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Mps1-IN-3 (2 mg/kg, i.v.) sensitizes glioblastoma cells in murine tumor models, with prolonged survival and no toxicity . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:Mps1 50 nM (IC 50 ) |
| Canonical SMILES | CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC3=C2NC=N3)NC4=C(C=C(C=C4)N5CCC(CC5)O)OC |
|---|---|
| Molecular Weight | 537.63 |
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