Fluorescent chloride ion indicator. Quenches via collision with chloride. Measures chloride transport in liposome membranes.
Storage Temp
Store at 2-8°C,Protected from light,Argon charged
Shipped In
Wet ice
Grade
for fluorescence analysis
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
MQAE is a fluorescent chloride ion indicator that is more sensitive and selective than 36Cl and microelectrode-based methods for chloride measurement in cells. MQAE is a fluorescent indicator that is quenched via collision with chloride. 1-(Ethoxycarbonylmethyl)-6-methoxyquinolinium bromide, a fluorescent chloride indicator dye, may be used to measure intracellular and extracellular chloride concentrations.
1.Sun Weijia, Li Yuheng, Li Jianwei, Tan Yingjun, Yuan Xinxin, Meng Haoye, Ye Jianting, Zhong Guohui, Jin XiaoYan, Liu Zizhong, Du Ruikai, Xing Wenjuan, Zhao Dingsheng, Song Jinping, Li Youyou, Pan Junjie, Zhao Yunzhang, Li Qi, Wang Aiyuan, Ling Shukuan, Dai Rongji, Li Yingxian. (2023) Mechanical stimulation controls osteoclast function through the regulation of Ca2+-activated Cl− channel Anoctamin 1. Communications Biology, 6 (1):(1-13). [PMID:37055517][10.1038/s42003-023-04806-1]
2.Xi-Hui Yu, Xiong-Jie Cai, Xiao-Qiao Hong, Kin Yip Tam, Kun Zhang, Wen-Hua Chen. (2019) Synthesis and biological evaluation of aza-crown ether–squaramide conjugates as anion/cation symporters. Future Medicinal Chemistry, 11 (10):[PMID:31280669][10.4155/fmc-2018-0595]
3.Xi-Hui Yu,Xiao-Qiao Hong,Wen-Hua Chen. (2019-01-30) Fluorinated bisbenzimidazoles: a new class of drug-like anion transporters with chloride-mediated, cell apoptosis-inducing activity.. Organic & biomolecular chemistry, 17 ((6)):(1558-1571). [PMID:30694281]
References
1.Huang W et al.. (2020) Increased intracellular Cl- concentration improves airway epithelial migration by activating the RhoA/ROCK Pathway.. Theranostics, 10 (19):(8528-8540). [PMID:32754261]
2.Kaneko Y et al.. (2016) Oxytocin modulates GABAAR subunits to confer neuroprotection in stroke in vitro.. Sci Rep, 6 (35659). [PMID:27767042]
3.Pampaloni NP et al.. (2018) Single-layer graphene modulates neuronal communication and augments membrane ion currents.. Nat Nanotechnol, 13 (8):(755-764). [PMID:29892019]
4.Sun Weijia, Li Yuheng, Li Jianwei, Tan Yingjun, Yuan Xinxin, Meng Haoye, Ye Jianting, Zhong Guohui, Jin XiaoYan, Liu Zizhong, Du Ruikai, Xing Wenjuan, Zhao Dingsheng, Song Jinping, Li Youyou, Pan Junjie, Zhao Yunzhang, Li Qi, Wang Aiyuan, Ling Shukuan, Dai Rongji, Li Yingxian. (2023) Mechanical stimulation controls osteoclast function through the regulation of Ca2+-activated Cl− channel Anoctamin 1. Communications Biology, 6 (1):(1-13). [PMID:37055517][10.1038/s42003-023-04806-1]
5.Xi-Hui Yu, Xiong-Jie Cai, Xiao-Qiao Hong, Kin Yip Tam, Kun Zhang, Wen-Hua Chen. (2019) Synthesis and biological evaluation of aza-crown ether–squaramide conjugates as anion/cation symporters. Future Medicinal Chemistry, 11 (10):[PMID:31280669][10.4155/fmc-2018-0595]
6.Xi-Hui Yu,Xiao-Qiao Hong,Wen-Hua Chen. (2019-01-30) Fluorinated bisbenzimidazoles: a new class of drug-like anion transporters with chloride-mediated, cell apoptosis-inducing activity.. Organic & biomolecular chemistry, 17 ((6)):(1558-1571). [PMID:30694281]
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