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MRGPRX2 antagonist 17 , CAS No.M612016

Item Number

M612016

Grouped product items
SKU	Size	Availability	Price	Qty
M612016-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90	+-
M612016-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90	+-

Basic Description

Specifications & Purity	Moligand™
Grade	Moligand™

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Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

INCHI	InChI=1S/C23H21F4N5O3/c1-14(31-9-6-23(26,27)17(13-31)15-4-7-32(34)8-5-15)22(33)30-20-11-29-21(12-28-20)35-19-3-2-16(24)10-18(19)25/h2-5,7-8,10-12,14,17H,6,9,13H2,1H3,(H,28,30,33)/t14-,17+/m0/s1
InChi Key	UOCITXUZOXOHLH-WMLDXEAASA-N
Canonical SMILES	C[C@@H](C(=O)Nc1ncc(nc1)Oc1c(cc(cc1)F)F)N1CCC([C@H](C1)c1cc[n+](cc1)[O-])(F)F
Isomeric SMILES	C[C@@H](C(=O)NC1=CN=C(C=N1)OC2=C(C=C(C=C2)F)F)N3CCC([C@H](C3)C4=CC=[N+](C=C4)[O-])(F)F
PubChem CID	164734529

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

1. Ogasawara H, Noguchi M. (2021) Therapeutic Potential of MRGPRX2 Inhibitors on Mast Cells.. Cells, 10 (11): (1755-70). [PMID:34831128] [10.3390/cells10112906]
2. Numata T, Harada K, Nakae S. (2022) Roles of Mast Cells in Cutaneous Diseases.. Front Immunol, 13 (13): (923495). [PMID:35874756] [10.1021/op500134e]
3. Trier AM, Kim BS. (2022) Structural insights into MRGPRX2: A new vision of itch and allergy.. J Allergy Clin Immunol, 149 (4): (1221-1222). [PMID:35090947] [10.1021/op500134e]
4. Al Hamwi G, Riedel YK, Clemens S, Namasivayam V, Thimm DT, Müller CE. (2022) Mas-related G protein-coupled receptors X (MRGPRX): Orphan GPCRs with potential as targets for future drugs.. Pharmacol Ther, 71 (13): (108259). [PMID:35934214] [10.1021/op500134e]

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