MRS 2179 - ≥98%, high purity , CAS No.101204-49-3, Antagonist of P2Y 1 receptor

Item Number

M275550

Grouped product items
SKU	Size	Availability	Price
M275550-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$109.90
M275550-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$199.90
M275550-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$807.90

Potent, selective P2Y 1 antagonist

View related series

Basic Description

Synonyms	101204-49-3\|MRS 2179\|[(2R,3S,5R)-5-[6-(methylamino)purin-9-yl]-2-(phosphonooxymethyl)oxolan-3-yl] dihydrogen phosphate\|MRS 2179 ammonium salt\|MRS2179\|CHEMBL129841\|MRS-2179\|2'-DEOXY-N6-METHYLADENOSINE 3',5'-BISPHOSPHATE TETRAAMMONIUM SALT\|CHEMBL1096400\|Lop
Specifications & Purity	≥98%
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of P2Y 1 receptor
Product Description	Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Names and Identifiers

IUPAC Name	[(2R,3S,5R)-5-[6-(methylamino)purin-9-yl]-2-(phosphonooxymethyl)oxolan-3-yl] dihydrogen phosphate
INCHI	InChI=1S/C11H17N5O9P2/c1-12-10-9-11(14-4-13-10)16(5-15-9)8-2-6(25-27(20,21)22)7(24-8)3-23-26(17,18)19/h4-8H,2-3H2,1H3,(H,12,13,14)(H2,17,18,19)(H2,20,21,22)/t6-,7+,8+/m0/s1
InChi Key	CCPLITQNIFLYQB-XLPZGREQSA-N
Canonical SMILES	CNC1=C2C(=NC=N1)N(C=N2)C3CC(C(O3)COP(=O)(O)O)OP(=O)(O)O
Isomeric SMILES	CNC1=C2C(=NC=N1)N(C=N2)[C@H]3C[C@@H]([C@H](O3)COP(=O)(O)O)OP(=O)(O)O
PubChem CID	5311303

PubChem CID

CAS Registry No.

GPCRdb Ligand

References

1. Nandanan E, Camaioni E, Jang SY, Kim YC, Cristalli G, Herdewijn P, Secrist 3rd JA, Tiwari KN, Mohanram A, Harden TK et al.. (1999) Structure-activity relationships of bisphosphate nucleotide derivatives as P2Y1 receptor antagonists and partial agonists.. J Med Chem, 42 (9): (1625-38). [PMID:10229631]
2. Zeng J et al.. (2014) P2Y13 receptor-mediated rapid increase in intracellular calcium induced by ADP in cultured dorsal spinal cord microglia.. Neurochem Res, 39 (11): (2240-50). [PMID:25186167]
3. Wu J et al.. (2017) P2Y1R is involved in visceral hypersensitivity in rats with experimental irritable bowel syndrome.. World J Gastroenterol, 23 (34): (6339-6349). [PMID:28974901]
4. Campwala H et al.. (2014) P2Y6 receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells.. J Cell Sci, 127 (22): (4964-73). [PMID:25271060]

Solution Calculators

Determine the necessary mass, volume, or concentration for preparing a solution.

Determine the dilution needed to prepare a stock solution.

Basic Description