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MRS 2395 , CAS No.491611-55-3
an antagonist of the P2Y12 purinoceptor
Basic Description Synonyms 491611-55-3|mrs2395|MRS 2395|2,2-DIMETHYL-PROPIONIC ACID 3-(2-CHLORO-6-METHYLAMINOPURIN-9-YL)-2-(2,2-DIMETHYL-PROPIONYLOXYMETHYL)-PROPYL ESTER|CHEMBL347921|[2-[[2-chloro-6-(methylamino)purin-9-yl]methyl]-3-(2,2-dimethylpropanoyloxy)propyl] 2,2-dimethylpro Storage Temp Room temperature Shipped In Normal Product Description MRS 2395 is an antagonist for the P2Y12 purinoceptor, which causes platelet aggregation in rats via ADP induction. Studies indicate that MRS 2395 reverses the inhibition of cAMP in rat and human platelets by antagonizing the effects of ADP on cAMP in the presence of PGE. It is known that this inhibition occurs without affecting the purinoceptor P2Y1 in transfected astrocytoma cells.
Names and Identifiers IUPAC Name [2-[[2-chloro-6-(methylamino)purin-9-yl]methyl]-3-(2,2-dimethylpropanoyloxy)propyl] 2,2-dimethylpropanoate INCHI InChI=1S/C20H30ClN5O4/c1-19(2,3)16(27)29-9-12(10-30-17(28)20(4,5)6)8-26-11-23-13-14(22-7)24-18(21)25-15(13)26/h11-12H,8-10H2,1-7H3,(H,22,24,25) InChi Key NASABYJQIYJDID-UHFFFAOYSA-N Canonical SMILES CC(C)(C)C(=O)OCC(CN1C=NC2=C(N=C(N=C21)Cl)NC)COC(=O)C(C)(C)C Isomeric SMILES CC(C)(C)C(=O)OCC(CN1C=NC2=C(N=C(N=C21)Cl)NC)COC(=O)C(C)(C)C WGK Germany 3 PubChem CID 10071919 Molecular Weight 439.94
Chemical and Physical Properties Solubility Soluble in DMSO: >10 mg/mL: water: insoluble
Safety and Hazards(GHS) WGK Germany 3 RIDADR NONHforallmodesoftransport
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