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MRT67307 - ≥98%, high purity , CAS No.1190378-57-4, Inhibitor of inhibitor of nuclear factor kappa B kinase subunit epsilon;Inhibitor of TANK binding kinase 1

Moligand™
≥98%

CAS#: 1190378-57-4
Formula: C₂₆H₃₆N₆O₂
Molecular Weight: 464.6
PubChem CID: 44464263

Item Number

M126461

Grouped product items
SKU	Size	Availability	Price
M126461-5mg	5mg	In stock	$94.90
M126461-10mg	10mg	In stock	$153.90
M126461-25mg	25mg	In stock	$346.90
M126461-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$652.90
M126461-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$842.90

View related series

inhibitor of nuclear factor kappa B kinase subunit epsilon Inhibitor TANK binding kinase 1 Inhibitor

Basic Description

Synonyms	MRT67307\|1190378-57-4\|MRT-67307\|MEY37JZ4XR\|N-[3-[[5-cyclopropyl-2-[3-(morpholin-4-ylmethyl)anilino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide\|UNII-MEY37JZ4XR\|CHEMBL3605057\|Cyclobutanecarboxamide, N-(3-((5-cyclopropyl-2-((3-(4-morpholinylmethyl)phe
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	MRT67307 is an aminopyrimidine derivative with an IC 50 value of 19. It is known to induce TLR-mediated production of anti-inflammatory cytokines. In addition, MRT67307 can prevent the secretion of proinflammatory cytokines. MRT67307 is a dual inhibitor o
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of inhibitor of nuclear factor kappa B kinase subunit epsilon;Inhibitor of TANK binding kinase 1

Associated Targets

STK17A Tchem Serine/threonine-protein kinase 17A 0 Activities

Discover Target: STK17A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

STK17B Tchem Serine/threonine-protein kinase 17B 0 Activities

Discover Target: STK17B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IKBKE Tchem Inhibitor of nuclear factor kappa-B kinase subunit epsilon 1 Activities

Discover Target: IKBKE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TBK1 Tchem Serine/threonine-protein kinase TBK1 2 Activities

Discover Target: TBK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDK1 Tchem [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial 0 Activities

Discover Target: PDK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MARK3 Tchem MAP/microtubule affinity-regulating kinase 3 0 Activities

Discover Target: MARK3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MARK4 Tchem MAP/microtubule affinity-regulating kinase 4 0 Activities

Discover Target: MARK4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BMP2K Tchem BMP-2-inducible protein kinase 0 Activities

Discover Target: BMP2K

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AAK1 Tchem AP2-associated protein kinase 1 0 Activities

Discover Target: AAK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ULK1 Tchem Serine/threonine-protein kinase ULK1 1 Activities

Discover Target: ULK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ULK2 Tchem Serine/threonine-protein kinase ULK2 1 Activities

Discover Target: ULK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NUAK2 Tchem NUAK family SNF1-like kinase 2 0 Activities

Discover Target: NUAK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NUAK1 Tchem NUAK family SNF1-like kinase 1 0 Activities

Discover Target: NUAK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-[3-[[5-cyclopropyl-2-[3-(morpholin-4-ylmethyl)anilino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide
INCHI	InChI=1S/C26H36N6O2/c33-25(21-5-2-6-21)28-11-3-10-27-24-23(20-8-9-20)17-29-26(31-24)30-22-7-1-4-19(16-22)18-32-12-14-34-15-13-32/h1,4,7,16-17,20-21H,2-3,5-6,8-15,18H2,(H,28,33)(H2,27,29,30,31)
InChi Key	UKBGBACORPRCGG-UHFFFAOYSA-N
Canonical SMILES	C1CC(C1)C(=O)NCCCNC2=NC(=NC=C2C3CC3)NC4=CC=CC(=C4)CN5CCOCC5
Isomeric SMILES	C1CC(C1)C(=O)NCCCNC2=NC(=NC=C2C3CC3)NC4=CC=CC(=C4)CN5CCOCC5
PubChem CID	44464263
Molecular Weight	464.6

PubChem CID

44464263

CAS Registry No.

1190378-57-4

RCSB PDB Ligand

1FV

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
K2104252	Certificate of Analysis	Aug 07, 2023	M126461
K2104256	Certificate of Analysis	Aug 07, 2023	M126461
K2104496	Certificate of Analysis	Aug 07, 2023	M126461
K2104498	Certificate of Analysis	Aug 07, 2023	M126461
K2104499	Certificate of Analysis	Aug 07, 2023	M126461

References

1. Yu J, Zhou X, Chang M, Nakaya M, Chang JH, Xiao Y, Lindsey JW, Dorta-Estremera S, Cao W, Zal A et al.. (2015) Regulation of T-cell activation and migration by the kinase TBK1 during neuroinflammation.. Nat Commun, 6 (3): (6074). [PMID:25606824]
2. Clark K, Peggie M, Plater L, Sorcek RJ, Young ER, Madwed JB, Hough J, McIver EG, Cohen P. (2011) Novel cross-talk within the IKK family controls innate immunity.. Biochem J, 434 (1): (93-104). [PMID:21138416]

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