MS 436 - 95%, high purity , CAS No.1395084-25-9, Inhibitor of bromodomain containing 4

Item Number

M288001

• Synonyms: (E)-4-[2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-2-pyridinylbenzenesulfonamide;MS436;4-[(2Z)-2-(2-amino-5-methyl-4-oxocyclohexa-2,5-dien-1-ylidene)hydrazinyl]-N-pyridin-2-ylbenzenesulfonamide;MS-436;4-[(1E)-2-(2-Amino-4-hydroxy-5-methylphenyl)diazen
• Specifications & Purity: Moligand™, ≥95%
• Biochemical and Physiological Mechanisms: Potent and selective BRD4 bromodomain inhibitor (Ki= 30 - 50 nM for the first bromodomain (BRD4(1)). Exhibits 10-fold selectivity for BRD4(1) over BRD4(2). Blocks BRD4 transcriptional activity in lipopolysaccharide-induced production of both nitric oxide
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Inhibitor of bromodomain containing 4

Product Description

Product introduction

Ms436 is a bromodomain inhibitor that effectively acts on Brd4 brd1 with a Ki of 30-50 nm, 10 times higher than that of BRD2.