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Orphan and other 7TM receptors
G protein-coupled receptors (GPCRs)
MS48107 , CAS No.M612092, Allosteric modulator of GPR68

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MS48107 , CAS No.M612092, Allosteric modulator of GPR68

Moligand™

PubChem CID: 139030523

Item Number

M612092

Grouped product items
SKU	Size	Availability	Price	Qty
M612092-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$274.90
M612092-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$870.90

View related series

GPR68 Allosteric modulator

Basic Description

Synonyms	GPR68 α-PAM 71;compound 71
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	ALLOSTERIC MODULATOR
Mechanism of action	Allosteric modulator of GPR68

Associated Targets

GPR4 Tchem G-protein coupled receptor 4 0 Activities

Discover Target: GPR4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR2B Tclin 5-hydroxytryptamine receptor 2B 0 Activities

Discover Target: HTR2B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GPR65 Tbio Psychosine receptor 0 Activities

Discover Target: GPR65

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GPR68 Tchem Ovarian cancer G-protein coupled receptor 1 0 Activities

Discover Target: GPR68

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MTNR1A Tclin Melatonin receptor type 1A 0 Activities

Discover Target: MTNR1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MTNR1B Tclin Melatonin receptor type 1B 0 Activities

Discover Target: MTNR1B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(2-(4-Amino-6-((4-phenoxybenzyl)amino)-1,3,5-triazin-2-yl)-3-fluorophenyl)methanol
INCHI	InChI=1S/C23H20FN5O2/c24-19-8-4-5-16(14-30)20(19)21-27-22(25)29-23(28-21)26-13-15-9-11-18(12-10-15)31-17-6-2-1-3-7-17/h1-12,30H,13-14H2,(H3,25,26,27,28,29)
InChi Key	KKHDNAZPEMYUNO-UHFFFAOYSA-N
Canonical SMILES	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F
Isomeric SMILES	C1=CC=C(C=C1)OC2=CC=C(C=C2)CNC3=NC(=NC(=N3)N)C4=C(C=CC=C4F)CO
PubChem CID	139030523

Database links

GPCRdb Ligand	MS48107
PubChem CID	139030523

Certificates

Certificate of Analysis(COA)

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References

1. Yu X, Huang XP, Kenakin TP, Slocum ST, Chen X, Martini ML, Liu J, Jin J. (2019) Design, Synthesis, and Characterization of Ogerin-Based Positive Allosteric Modulators for G Protein-Coupled Receptor 68 (GPR68).. J Med Chem, 62 (16): (7557-7574). [PMID:31298539]

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