pAb; Rabbit anti Human MX1 Antibody; WB, IHC; Unconjugated
| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| Ab116582-10μl | 10μl | In stock | $59.90 | |
| Ab116582-50μl | 50μl | In stock | $189.90 | |
| Ab116582-100μl | 100μl | In stock | $299.90 | |
| Ab116582-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,699.90 |
pAb; Rabbit anti Human MX1 Antibody; WB, IHC; Unconjugated
| Product Name | MX1 Antibody - Primary antibody, specific to MX1 |
|---|---|
| Synonyms | human interferon-regulated resistance GTP-binding protein MXA10IFI-78Khomolog of murine (interferon-inducibleprotein p78); IFI78; IFI-78K; Mx1; MxA; myxovirus (influenza virus) resistance 1, interferon-inducible protein p78(mouse); Human interferon regula |
| Specifications & Purity | ExactAb™, Validated, Carrier Free, Azide Free, Lot by Lot |
| Host species | Rabbit |
| Specificity | MX1 |
| Immunogen | Recombinant MX1 expressed in E.coli (AA 80-342) |
| Positive Control | WB: Mouse lung, Mouse spleen, HeLa, A549 and C6 lysates. IHC: Human skin cancer, liver, breast cancer tissues. |
| Conjugation | Unconjugated |
| Grade | Azide Free, Carrier Free, ExactAb™, Validated |
| Product Description |
Rabbit anti Human MX1 Antibody, Polyclonal, could be used for WB, IHC and so on. |
| SDS-PAGE | 150 kDa |
|---|---|
| Purification Method | Antigen affinity purified + Protein A purified |
| Form | Liquid |
| Concentration | Lot by Lot |
| Storage Temp | Store at -20°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle. |
MX1 Antibody (Ab116582) - Western Blot
All lanes: MX1 Antibody (Ab116582) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 76 kDa
Observed band size: 78 kDa
Exposure time: 4.6 s
MX1 Antibody (Ab116582) - IHC
DAB staining on IHC
Samples: Human Skin cancer Tissue
Primary Ab: 10 µg/mL MX1 Antibody (Ab116582)
Second Ab: 2 µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody.
MX1 Antibody (Ab116582) - IHC
DAB staining on IHC
Samples: Human Liver Tissue
Primary Ab: 10 µg/mL MX1 Antibody (Ab116582)
Second Ab: 2 µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody.
MX1 Antibody (Ab116582) - IHC
DAB staining on IHC
Samples: Human Breast cancer Tissue
Primary Ab: 10 µg/mL MX1 Antibody (Ab116582)
Second Ab: 2 µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Application | Dilution info |
|---|---|
| IHC | 5-20 µg/mL |
| WB |
0.5-5 µg/mL
|
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 ZJ24F0404483 | Certificate of Analysis | Apr 12, 2024 | Ab116582 |
| ZJ24F0404482 | Certificate of Analysis | Apr 12, 2024 | Ab116582 |
| ZJ24F0404481 | Certificate of Analysis | Apr 12, 2024 | Ab116582 |
| 1. Lussier MP, Cayouette S, Lepage PK, Bernier CL, Francoeur N, St-Hilaire M, Pinard M, Boulay G. (2005) MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC.. J Biol Chem, 280 (19): (19393-400). [PMID:15757897] |
| 2. M A Horisberger,G K McMaster,H Zeller,M G Wathelet,J Dellis,J Content. (1990-03-01) Cloning and sequence analyses of cDNAs for interferon- and virus-induced human Mx proteins reveal that they contain putative guanine nucleotide-binding sites: functional study of the corresponding gene promoter.. Journal of virology, 64 ((3)): (1171-1181). [PMID:2154602] |
| 3. Pavlovic, J J, Zürcher, T T, Haller, O O and Staeheli, P P.. (1990) Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein.. Journal of virology, [PMID:2161946] |
| 4. Aebi, M M and 8 more authors.. (1989) cDNA structures and regulation of two interferon-induced human Mx proteins.. Molecular and cellular biology, [PMID:2481229] |
| 5. Weitz, G G, Bekisz, J J, Zoon, K K and Arnheiter, H H.. (1989) Purification and characterization of a human Mx protein.. Journal of interferon research, [PMID:2607176] |
| 6. Pitossi, F F and 7 more authors.. (1993) A functional GTP-binding motif is necessary for antiviral activity of Mx proteins.. Journal of virology, [PMID:8411374] |
| 7. Ponten, A A, Sick, C C, Weeber, M M, Haller, O O and Kochs, G G.. (1997) Dominant-negative mutants of human MxA protein: domains in the carboxy-terminal moiety are important for oligomerization and antiviral activity.. Journal of virology, [PMID:9060610] |
| 8. Kochs, G G and Haller, O O.. (1999) GTP-bound human MxA protein interacts with the nucleocapsids of Thogoto virus (Orthomyxoviridae).. The Journal of biological chemistry, (12): [PMID:9933640] |
| 9. Hattori, M M and 64 more authors.. (2000) The DNA sequence of human chromosome 21.. Nature, (18): [PMID:10830953] |
| 10. Tazi-Ahnini, R R and 7 more authors.. (2000) Structure and polymorphism of the human gene for the interferon-induced p78 protein (MX1): evidence of association with alopecia areata in the Down syndrome region.. Human genetics, [PMID:10942113] |
| 11. Kochs, Georg G, Janzen, Christian C, Hohenberg, Heinz H and Haller, Otto O.. (2002) Antivirally active MxA protein sequesters La Crosse virus nucleocapsid protein into perinuclear complexes.. Proceedings of the National Academy of Sciences of the United States of America, (5): [PMID:11880649] |
| 12. Bridgen, Anne A, Dalrymple, David A DA, Weber, Friedemann F and Elliott, Richard M RM.. (2004) Inhibition of Dugbe nairovirus replication by human MxA protein.. Virus research, [PMID:14687945] |
| 13. Turan, Kadir K and 5 more authors.. (2004) Nuclear MxA proteins form a complex with influenza virus NP and inhibit the transcription of the engineered influenza virus genome.. Nucleic acids research, [PMID:14752052] |
| 14. Andersson, Ida I and 6 more authors.. (2004) Human MxA protein inhibits the replication of Crimean-Congo hemorrhagic fever virus.. Journal of virology, [PMID:15047845] |
| 15. Reichelt, Mike M, Stertz, Silke S, Krijnse-Locker, Jacomine J, Haller, Otto O and Kochs, Georg G.. (2004) Missorting of LaCrosse virus nucleocapsid protein by the interferon-induced MxA GTPase involves smooth ER membranes.. Traffic (Copenhagen, Denmark), [PMID:15355513] |
| 16. Zhao, Chen C, Denison, Carilee C, Huibregtse, Jon M JM, Gygi, Steven S and Krug, Robert M RM.. (2005) Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways.. Proceedings of the National Academy of Sciences of the United States of America, (19): [PMID:16009940] |
| 17. Leroy, M M, Pire, G G, Baise, E E and Desmecht, D D.. (2006) Expression of the interferon-alpha/beta-inducible bovine Mx1 dynamin interferes with replication of rabies virus.. Neurobiology of disease, [PMID:16202617] |
| 18. Kochs, Georg G, Reichelt, Mike M, Danino, Dganit D, Hinshaw, Jenny E JE and Haller, Otto O.. (2005) Assay and functional analysis of dynamin-like Mx proteins.. Methods in enzymology, [PMID:16413306] |
| 19. Stertz, Silke S and 6 more authors.. (2006) Interferon-induced, antiviral human MxA protein localizes to a distinct subcompartment of the smooth endoplasmic reticulum.. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, [PMID:16978069] |
| 20. and Mundt, Egbert E.. (2007) Human MxA protein confers resistance to double-stranded RNA viruses of two virus families.. The Journal of general virology, [PMID:17374778] |
| 21. Yu, Zhijian Z and 7 more authors.. (2008) GTPase activity is not essential for the interferon-inducible MxA protein to inhibit the replication of hepatitis B virus.. Archives of virology, [PMID:18668195] |
| 22. Netherton, Christopher L CL and 6 more authors.. (2009) Inhibition of a large double-stranded DNA virus by MxA protein.. Journal of virology, [PMID:19109387] |
| 23. Gao, Song S and 6 more authors.. (2010) Structural basis of oligomerization in the stalk region of dynamin-like MxA.. Nature, (27): [PMID:20428112] |
| 24. Haller, Otto O, Gao, Song S, von der Malsburg, Alexander A, Daumke, Oliver O and Kochs, Georg G.. (2010) Dynamin-like MxA GTPase: structural insights into oligomerization and implications for antiviral activity.. The Journal of biological chemistry, (10): [PMID:20538602] |
| 25. Ku, Chia-Chi CC and 9 more authors.. (2011) Herpes simplex virus-1 induces expression of a novel MxA isoform that enhances viral replication.. Immunology and cell biology, [PMID:20603636] |
| 26. Haller, Otto O and Kochs, Georg G.. (2011) Human MxA protein: an interferon-induced dynamin-like GTPase with broad antiviral activity.. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, [PMID:21166595] |
| 27. Wisskirchen, Christian C, Ludersdorfer, Thomas H TH, Müller, Dominik A DA, Moritz, Eva E and Pavlovic, Jovan J.. (2011) Interferon-induced antiviral protein MxA interacts with the cellular RNA helicases UAP56 and URH49.. The Journal of biological chemistry, (7): [PMID:21859714] |
| 28. von der Malsburg, Alexander A, Abutbul-Ionita, Inbal I, Haller, Otto O, Kochs, Georg G and Danino, Dganit D.. (2011) Stalk domain of the dynamin-like MxA GTPase protein mediates membrane binding and liposome tubulation via the unstructured L4 loop.. The Journal of biological chemistry, (28): [PMID:21900240] |
| 29. Gao, Song S and 7 more authors.. (2011) Structure of myxovirus resistance protein a reveals intra- and intermolecular domain interactions required for the antiviral function.. Immunity, (28): [PMID:21962493] |
| 30. Numajiri Haruki, Akiko A, Naito, Tadasuke T, Nishie, Tomomi T, Saito, Shoko S and Nagata, Kyosuke K.. (2011) Interferon-inducible antiviral protein MxA enhances cell death triggered by endoplasmic reticulum stress.. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, [PMID:21992152] |
| 31. Hendriks, Ivo A; Treffers, Louise W; Verlaan-de Vries, Matty; Olsen, Jesper V and Vertegaal, Alfred C O.. (2015) SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage.. Cell reports, (17): [PMID:25772364] |
