N-[(1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyloxycarbonyl]-1,8-diamino-3,6-dioxaoctane - for Copper-free Click Chemistry, high purity , CAS No.1263166-93-3
N-[(1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyloxycarbonyl]-1,8-diamino-3,6-dioxaoctane - for Copper-free Click Chemistry, high purity , CAS No.1263166-93-3
Amine functionalized cyclooctyne derivative. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. This strained cyclooctyne will react with azide functionalized compounds or biomolecules without the need for a copper catalyst to result in a stable triazole linkage.N-[(1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyloxycarbonyl]-1,8-diamino-3,6-dioxaoctane may be used to functionalize hyaluronic acid with bicyclo[6.1.0]nonyne (BCN) for the development of responsive HA-based physical hydrogels with tunable properties.
1.Favuzza P, de Lera Ruiz M, Thompson JK, Triglia T, Ngo A, Steel RWJ, Vavrek M, Christensen J, Healer J, Boyce C et al.. (2020) Dual Plasmepsin-Targeting Antimalarial Agents Disrupt Multiple Stages of the Malaria Parasite Life Cycle.. Cell Host Microbe, 27 (4):(642-658.e12). [PMID:32109369][10.1021/op500134e]
2.Jan Dommerholt,Samuel Schmidt,Rinske Temming,Linda J A Hendriks,Floris P J T Rutjes,Jan C M van Hest,Dirk J Lefeber,Peter Friedl,Floris L van Delft. (2010-09-22) Readily accessible bicyclononynes for bioorthogonal labeling and three-dimensional imaging of living cells.. Angewandte Chemie (International ed. in English), 49 ((49)):(9422-9425). [PMID:20857472]
3.Jonas Christoffersson, Christopher Aronsson, Michael Jury, Robert Selegård, Daniel Aili, Carl-Fredrik Mandenius,. (2018-12-14) Fabrication of modular hyaluronan-PEG hydrogels to support 3D cultures of hepatocytes in a perfused liver-on-a-chip device.. Biofabrication, 11 ((1)):( 015013-015013 ). [PMID:30523863]