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Basic Description
| Synonyms | 2-Acetamidofluorene|2-Acetylaminofluorene|53-96-3|N-(9H-Fluoren-2-yl)acetamide|N-2-Fluorenylacetamide|2-AAF|N-acetyl-2-aminofluorene|Acetamide, N-9H-fluoren-2-yl-|2-(Acetylamino)fluorene|2-FAA|N-Fluoren-2-ylacetamide|2-Acetaminofluorene|2-Fluorenylacetami |
|---|---|
| Specifications & Purity | ≥98% |
| Biochemical and Physiological Mechanisms | A genotoxic carcinogen that is used to model liver carcinogenesis in rat. When N-hydroxylated by cytochrome CYP1A2 in the liver, 2-AAF forms adducts with DNA and is tumorigenic in liver and bladder. |
| Storage Temp | Protected from light,Argon charged |
| Shipped In | Normal |
| Product Description | Usually used to induce liver cancer in animal models such as the 2-AAF/partial hepatectomy rat, study the mechanism of liver carcinogenesis and as a reference material during its identification or quantitation. |
Associated Targets
CTH Tchem Cystathionine gamma-lyase 0 Activities
CYP1A2 Tchem Cytochrome P450 1A2 1 Activities
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CNR1 Tclin Cannabinoid receptor 1 0 Activities
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DRD2 Tclin D(2) dopamine receptor 0 Activities
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DRD4 Tchem D(4) dopamine receptor 0 Activities
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CYP3A4 Tclin Cytochrome P450 3A4 0 Activities
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ERBB2 Tclin Receptor tyrosine-protein kinase erbB-2 0 Activities
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ELANE Tclin Neutrophil elastase 0 Activities
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EGFR Tclin Epidermal growth factor receptor 0 Activities
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AVPR1A Tclin Vasopressin V1a receptor 0 Activities
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ABCB1 Tchem Multidrug resistance protein 1 0 Activities
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HMGCR Tclin 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0 Activities
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HRH1 Tclin Histamine H1 receptor 0 Activities
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SLC6A3 Tclin Sodium-dependent dopamine transporter 0 Activities
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SLC6A4 Tclin Sodium-dependent serotonin transporter 0 Activities
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SIGMAR1 Tclin Sigma non-opioid intracellular receptor 1 0 Activities
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PTGS1 Tclin Prostaglandin G/H synthase 1 0 Activities
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CA2 Tclin Carbonic anhydrase 2 0 Activities
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DRD3 Tclin D(3) dopamine receptor 0 Activities
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FLT1 Tclin Vascular endothelial growth factor receptor 1 0 Activities
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CHRM3 Tclin Muscarinic acetylcholine receptor M3 0 Activities
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CHRM4 Tclin Muscarinic acetylcholine receptor M4 0 Activities
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ADRA2B Tclin Alpha-2B adrenergic receptor 0 Activities
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ADRA2C Tclin Alpha-2C adrenergic receptor 0 Activities
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HTR2A Tclin 5-hydroxytryptamine receptor 2A 0 Activities
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ADORA2A Tclin Adenosine receptor A2a 0 Activities
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ACHE Tclin Acetylcholinesterase 0 Activities
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ADRA1B Tclin Alpha-1B adrenergic receptor 0 Activities
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ADRA2A Tclin Alpha-2A adrenergic receptor 0 Activities
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ADRB1 Tclin Beta-1 adrenergic receptor 0 Activities
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ADRA1A Tclin Alpha-1A adrenergic receptor 0 Activities
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AR Tclin Androgen receptor 0 Activities
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MAOA Tclin Amine oxidase [flavin-containing] A 1 Activities
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AKR1B1 Tclin Aldose reductase 0 Activities
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ADORA1 Tclin Adenosine receptor A1 0 Activities
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HTR1A Tclin 5-hydroxytryptamine receptor 1A 0 Activities
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ADORA3 Tchem Adenosine receptor A3 0 Activities
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HTR6 Tchem 5-hydroxytryptamine receptor 6 0 Activities
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HTR2B Tclin 5-hydroxytryptamine receptor 2B 0 Activities
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EDNRA Tclin Endothelin-1 receptor 0 Activities
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KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities
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OPRD1 Tclin Delta-type opioid receptor 0 Activities
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OPRK1 Tclin Kappa-type opioid receptor 0 Activities
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OPRM1 Tclin Mu-type opioid receptor 0 Activities
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NOS2 Tchem Nitric oxide synthase, inducible 0 Activities
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TACR1 Tclin Substance-P receptor 0 Activities
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NOS1 Tchem Nitric oxide synthase, brain 0 Activities
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Names and Identifiers
| Pubchem Sid | 488179955 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488179955 |
| IUPAC Name | N-(9H-fluoren-2-yl)acetamide |
| INCHI | InChI=1S/C15H13NO/c1-10(17)16-13-6-7-15-12(9-13)8-11-4-2-3-5-14(11)15/h2-7,9H,8H2,1H3,(H,16,17) |
| InChi Key | CZIHNRWJTSTCEX-UHFFFAOYSA-N |
| Canonical SMILES | CC(=O)NC1=CC2=C(C=C1)C3=CC=CC=C3C2 |
| Isomeric SMILES | CC(=O)NC1=CC2=C(C=C1)C3=CC=CC=C3C2 |
| WGK Germany | 3 |
| RTECS | AB9450000 |
| PubChem CID | 5897 |
| UN Number | 3077 |
| Packing Group | III |
| Molecular Weight | 223.27 |
| Beilstein | 2807677 |
| Reaxy-Rn | 2807677 |
Certificates
Certificate of Analysis(COA)
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 G2307213 | Certificate of Analysis | May 12, 2023 | F106909 |
| G2307245 | Certificate of Analysis | May 12, 2023 | F106909 |
| G2307282 | Certificate of Analysis | May 12, 2023 | F106909 |
| G2307283 | Certificate of Analysis | May 12, 2023 | F106909 |
| G2307284 | Certificate of Analysis | May 12, 2023 | F106909 |
| G2307286 | Certificate of Analysis | May 12, 2023 | F106909 |
| G2307302 | Certificate of Analysis | May 12, 2023 | F106909 |
| G2307314 | Certificate of Analysis | May 12, 2023 | F106909 |
Chemical and Physical Properties
| Solubility | Insoluble in water; Soluble in Alcohol,Ether |
|---|---|
| Sensitivity | Light & Moisture Sensitive |
| Melt Point(°C) | 192-196°C |
Safety and Hazards(GHS)
| Pictogram(s) | GHS08, GHS07 |
|---|---|
| Signal | Danger |
| Hazard Statements | H302:Harmful if swallowed H350:May cause cancer |
| Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. |
| WGK Germany | 3 |
| RTECS | AB9450000 |
| Reaxy-Rn | 2807677 |
| Class | 9 |
| Merck Index | 4157 |
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