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N-[3-[3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl]-1H-indol-5-yl]acetamide , CAS No.N609320, Inhibitor of dual specificity tyrosine phosphorylation regulated kinase 2;Inhibitor of glycogen synthase kinase 3 beta;Inhibitor of homeodomain interacting protein kinase 2

  • Moligand™
Item Number
N609320
Grouped product items
SKUSizeAvailabilityPrice Qty
N609320-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,334.90
N609320-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,000.90

Basic Description

Synonymscompound 5b
Specifications & PurityMoligand™
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of dual specificity tyrosine phosphorylation regulated kinase 2;Inhibitor of glycogen synthase kinase 3 beta;Inhibitor of homeodomain interacting protein kinase 2

Associated Targets

DYRK2 Tchem Dual specificity tyrosine-phosphorylation-regulated kinase 2 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CSNK2A1 Tchem Casein kinase II subunit alpha 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HIPK2 Tchem Homeodomain-interacting protein kinase 2 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GSK3B Tclin Glycogen synthase kinase-3 beta 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

INCHI InChI=1S/C20H17N7O/c1-11(28)24-14-4-5-17-15(6-14)16(10-22-17)18-7-19(25-13-2-3-13)27-20(26-18)12(8-21)9-23-27/h4-7,9-10,13,22,25H,2-3H2,1H3,(H,24,28)
InChi Key UZZGMJZTCZOSGC-UHFFFAOYSA-N
Canonical SMILES N#Cc1cnn2c1nc(cc2NC1CC1)c1c[nH]c2c1cc(cc2)NC(=O)C
Isomeric SMILES CC(=O)NC1=CC2=C(C=C1)NC=C2C3=NC4=C(C=NN4C(=C3)NC5CC5)C#N
PubChem CID 136254272

Certificates

Certificate of Analysis(COA)

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Related Documents

References

1. Dowling JE, Chuaqui C, Pontz TW, Lyne PD, Larsen NA, Block MH, Chen H, Su N, Wu A, Russell D et al..  (2012)  Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided Hybridization..  ACS Med Chem Lett,  (4): (278-83).  [PMID:24900464]

Solution Calculators