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N-[3-[(4S)-2-amino-4-methyl-5,6-dihydro-1,3-thiazin-4-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide , CAS No.N609520, Inhibitor of beta-secretase 1;Inhibitor of beta-secretase 2

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N-[3-[(4S)-2-amino-4-methyl-5,6-dihydro-1,3-thiazin-4-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide , CAS No.N609520, Inhibitor of beta-secretase 1;Inhibitor of beta-secretase 2

Moligand™

PubChem CID: 50938551

Item Number

N609520

Grouped product items
SKU	Size	Availability	Price	Qty
N609520-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
N609520-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

beta-secretase 1 Inhibitor beta-secretase 2 Inhibitor

Basic Description

Synonyms	Example 1 (WO2011029803);compound J
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of beta-secretase 1;Inhibitor of beta-secretase 2

Associated Targets

BACE1 Tchem Beta-secretase 1 8 Activities

Discover Target: BACE1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BACE2 Tchem Beta-secretase 2 3 Activities

Discover Target: BACE2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-[3-[(4S)-2-amino-4-methyl-5,6-dihydro-1,3-thiazin-4-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide
INCHI	InChI=1S/C17H16ClFN4OS/c1-17(6-7-25-16(20)23-17)12-8-11(3-4-13(12)19)22-15(24)14-5-2-10(18)9-21-14/h2-5,8-9H,6-7H2,1H3,(H2,20,23)(H,22,24)/t17-/m0/s1
InChi Key	VVZZZUNCWSTIOI-KRWDZBQOSA-N
Canonical SMILES	Clc1ccc(nc1)C(=O)Nc1ccc(c(c1)[C@]1(C)CCSC(=N1)N)F
Isomeric SMILES	C[C@]1(CCSC(=N1)N)C2=C(C=CC(=C2)NC(=O)C3=NC=C(C=C3)Cl)F
PubChem CID	50938551

Database links

PubChem CID	50938551
ChEMBL Ligand	CHEMBL2347211
RCSB PDB Ligand	C6U

Certificates

Certificate of Analysis(COA)

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References

1. Esterházy D, Stützer I, Wang H, Rechsteiner MP, Beauchamp J, Döbeli H, Hilpert H, Matile H, Prummer M, Schmidt A et al.. (2011) Bace2 is a β cell-enriched protease that regulates pancreatic β cell function and mass.. Cell Metab, 14 (3): (365-77). [PMID:21907142]

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