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CAMK:Calcium/calmodulin-dependent protein kinases
N-[3-[[5-bromo-2-[[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide , CAS No.N609433, Inhibitor of serine/threonine kinase 17a

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N-[3-[[5-bromo-2-[[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide , CAS No.N609433, Inhibitor of serine/threonine kinase 17a

Moligand™

PubChem CID: 145900914

Item Number

N609433

Grouped product items
SKU	Size	Availability	Price	Qty
N609433-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
N609433-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

serine/threonine kinase 17a Inhibitor

Basic Description

Synonyms	compound 7
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of serine/threonine kinase 17a

Associated Targets

STK17A Tchem Serine/threonine-protein kinase 17A 0 Activities

Discover Target: STK17A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

STK17B Tchem Serine/threonine-protein kinase 17B 0 Activities

Discover Target: STK17B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TBK1 Tchem Serine/threonine-protein kinase TBK1 0 Activities

Discover Target: TBK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MARK3 Tchem MAP/microtubule affinity-regulating kinase 3 0 Activities

Discover Target: MARK3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MARK4 Tchem MAP/microtubule affinity-regulating kinase 4 0 Activities

Discover Target: MARK4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AAK1 Tchem AP2-associated protein kinase 1 0 Activities

Discover Target: AAK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MARK1 Tchem Serine/threonine-protein kinase MARK1 0 Activities

Discover Target: MARK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-[3-[[5-bromo-2-[[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide
INCHI	InChI=1S/C18H23BrF3N7O/c1-11-14(9-29(28-11)10-18(20,21)22)26-17-25-8-13(19)15(27-17)23-6-3-7-24-16(30)12-4-2-5-12/h8-9,12H,2-7,10H2,1H3,(H,24,30)(H2,23,25,26,27)
InChi Key	PJLYZTYJSMPZHT-UHFFFAOYSA-N
Canonical SMILES	Cc1nn(CC(F)(F)F)cc1Nc1ncc(Br)c(NCCCNC(=O)C2CCC2)n1
Isomeric SMILES	CC1=NN(C=C1NC2=NC=C(C(=N2)NCCCNC(=O)C3CCC3)Br)CC(F)(F)F
PubChem CID	145900914

Database links

PubChem CID	145900914

Certificates

Certificate of Analysis(COA)

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References

1. Drewry DH, Annor-Gyamfi JK, Wells CI, Pickett JE, Dederer V, Preuss F, Mathea S, Axtman AD. (2022) Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration.. J Med Chem, 65 (2): (1313-1328). [PMID:34333981]

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