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Home Applications Targets Kinases Other protein kinases N-[3-[[5-bromo-4-[(4-sulfamoylphenyl)methylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide , CAS No.N608711, Inhibitor of AP2 associated kinase 1;Inhibitor of BMP2 inducible kinase;Inhibitor of serine/threonine kinase 16;Inhibitor of tyrosine kinase 2
N-[3-[[5-bromo-4-[(4-sulfamoylphenyl)methylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide , CAS No.N608711, Inhibitor of AP2 associated kinase 1;Inhibitor of BMP2 inducible kinase;Inhibitor of serine/threonine kinase 16;Inhibitor of tyrosine kinase 2
Basic Description Synonyms compound 13 Specifications & Purity Moligand™ Grade Moligand™ Action Type INHIBITOR Mechanism of action Inhibitor of AP2 associated kinase 1;Inhibitor of BMP2 inducible kinase;Inhibitor of serine/threonine kinase 16;Inhibitor of tyrosine kinase 2
Names and Identifiers IUPAC Name N-[3-[[5-bromo-4-[(4-sulfamoylphenyl)methylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide INCHI InChI=1S/C22H24BrN7O3S/c23-19-14-26-21(29-20(19)25-13-15-6-8-18(9-7-15)34(24,32)33)27-16-4-3-5-17(12-16)28-22(31)30-10-1-2-11-30/h3-9,12,14H,1-2,10-11,13H2,(H,28,31)(H2,24,32,33)(H2,25,26,27,29) InChi Key OEZHSZIDGUKBRK-UHFFFAOYSA-N Canonical SMILES NS(=O)(=O)c1ccc(CNc2nc(Nc3cccc(NC(=O)N4CCCC4)c3)ncc2Br)cc1 Isomeric SMILES C1CCN(C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)NCC4=CC=C(C=C4)S(=O)(=O)N)Br PubChem CID 145900913
References 1. Drewry DH, Annor-Gyamfi JK, Wells CI, Pickett JE, Dederer V, Preuss F, Mathea S, Axtman AD. (2022) Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration.. J Med Chem, 65 (2): (1313-1328). [PMID:34333981 ]
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