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N-(3-((7-Chloro-5,8-dioxo-5,8-dihydroquinolin-6-yl)amino)bicyclo[1.1.1]pentan-1-yl)but-2-ynamide , CAS No.N608738, Inhibitor of enhancer of zeste 2 polycomb repressive complex 2 subunit;Inhibitor of nuclear receptor binding SET domain protein 1;Inhibitor of nuclear receptor binding SET domain protein 2

  • Moligand™
Item Number
N608738
Grouped product items
SKUSizeAvailabilityPrice Qty
N608738-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,334.90
N608738-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,000.90

Basic Description

Synonymscompound 15a
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of enhancer of zeste 2 polycomb repressive complex 2 subunit;Inhibitor of nuclear receptor binding SET domain protein 1;Inhibitor of nuclear receptor binding SET domain protein 2

Associated Targets

EZH2 Tclin Histone-lysine N-methyltransferase EZH2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NSD1 Tbio Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NSD2 Tchem Histone-lysine N-methyltransferase NSD2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name N-(3-((7-Chloro-5,8-dioxo-5,8-dihydroquinolin-6-yl)amino)bicyclo[1.1.1]pentan-1-yl)but-2-ynamide
INCHI InChI=1S/C18H14ClN3O3/c1-2-4-11(23)21-17-7-18(8-17,9-17)22-14-12(19)16(25)13-10(15(14)24)5-3-6-20-13/h3,5-6,22H,7-9H2,1H3,(H,21,23)
InChi Key XLARJZRINWFNRT-UHFFFAOYSA-N
Canonical SMILES O=C1C(=C(Cl)C(=O)c2ncccc12)NC12CC(C1)(NC(=O)C#CC)C2

Certificates

Certificate of Analysis(COA)

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Related Documents

References

1. Tang H, Yu A, Xing L, Chen X, Ding H, Yang H, Song Z, Shi Q, Geng M, Huang X et al..  (2023)  Structural Modification and Pharmacological Evaluation of Substituted Quinoline-5,8-diones as Potent NSD2 Inhibitors..  J Med Chem,  66  (2): (1634-1651).  [PMID:36642961]

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