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CAMK:Calcium/calmodulin-dependent protein kinases
N-(3-chlorophenyl)-4-[3-(piperazin-1-yl)phenyl]pyrimidin-2-amine , CAS No.N608742, Inhibitor of calcium/calmodulin-dependent protein kinase II delta subunit

N-(3-chlorophenyl)-4-[3-(piperazin-1-yl)phenyl]pyrimidin-2-amine , CAS No.N608742, Inhibitor of calcium/calmodulin-dependent protein kinase II delta subunit

Item Number

N608742

Grouped product items
SKU	Size	Availability	Price	Qty
N608742-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
N608742-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Basic Description

Synonyms	Scios-15b;compound 15b
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of calcium/calmodulin-dependent protein kinase II delta subunit

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IUPAC Name	N-(3-chlorophenyl)-4-[3-(piperazin-1-yl)phenyl]pyrimidin-2-amine
INCHI	InChI=1S/C20H20ClN5/c21-16-4-2-5-17(14-16)24-20-23-8-7-19(25-20)15-3-1-6-18(13-15)26-11-9-22-10-12-26/h1-8,13-14,22H,9-12H2,(H,23,24,25)
InChi Key	UGXVRWRXHWTSCU-UHFFFAOYSA-N
Canonical SMILES	Clc1cccc(c1)Nc1nccc(n1)c1cccc(c1)N1CCNCC1
Isomeric SMILES	C1CN(CCN1)C2=CC=CC(=C2)C3=NC(=NC=C3)NC4=CC(=CC=C4)Cl
PubChem CID	44453784

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1. Mavunkel B, Xu YJ, Goyal B, Lim D, Lu Q, Chen Z, Wang DX, Higaki J, Chakraborty I, Liclican A et al.. (2008) Pyrimidine-based inhibitors of CaMKIIdelta.. Bioorg Med Chem Lett, 18 (7): (2404-8). [PMID:18334293]

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