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N-(3-chlorophenyl)-4-methyl-3-(2-pyrazolo[1,5-a]pyrimidin-6-ylethynyl)benzamide , CAS No.N609420, Inhibitor of discoidin domain receptor tyrosine kinase 1;Inhibitor of KIT proto-oncogene; receptor tyrosine kinase

  • Moligand™
Item Number
N609420
Grouped product items
SKUSizeAvailabilityPrice Qty
N609420-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,334.90
N609420-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,000.90
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discoidin domain receptor tyrosine kinase 1 Inhibitor KIT proto-oncogene，receptor tyrosine kinase Inhibitor

Basic Description

Synonymscompound 7k
Specifications & PurityMoligand™
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of discoidin domain receptor tyrosine kinase 1;Inhibitor of KIT proto-oncogene; receptor tyrosine kinase

Associated Targets

DDR2 Tchem Discoidin domain-containing receptor 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

DDR1 Tchem Epithelial discoidin domain-containing receptor 1 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KIT Tclin Mast/stem cell growth factor receptor Kit 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name N-(3-chlorophenyl)-4-methyl-3-(2-pyrazolo[1,5-a]pyrimidin-6-ylethynyl)benzamide
INCHI InChI=1S/C22H15ClN4O/c1-15-5-7-18(22(28)26-20-4-2-3-19(23)12-20)11-17(15)8-6-16-13-24-21-9-10-25-27(21)14-16/h2-5,7,9-14H,1H3,(H,26,28)
InChi Key PSBGROLQRNSAMY-UHFFFAOYSA-N
Canonical SMILES Clc1cccc(c1)NC(=O)c1ccc(c(c1)C#Cc1cnc2n(c1)ncc2)C
Isomeric SMILES CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC=C2)Cl)C#CC3=CN4C(=CC=N4)N=C3
PubChem CID 71624791

Certificates

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Related Documents

 SDS

 Specification Sheet

References

1. Gao M, Duan L, Luo J, Zhang L, Lu X, Zhang Y, Zhang Z, Tu Z, Xu Y, Ren X et al..  (2013)  Discovery and optimization of 3-(2-(Pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamides as novel selective and orally bioavailable discoidin domain receptor 1 (DDR1) inhibitors..  J Med Chem,  56  (8): (3281-95).  [PMID:23521020]

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