N-[(3R)-8-[[5-chloro-4-[2-fluoro-6-(methylcarbamoyl)anilino]pyrimidin-2-yl]amino]-5,5-dimethyl-2-oxo-3,4-dihydro-1H-1-benzazepin-3-yl]pyrrolidine-1-carboxamide , CAS No.N609522, Inhibitor of interleukin 1 receptor associated kinase 3;Inhibitor of MET proto-oncogene; receptor tyrosine kinase;Inhibitor of sugen kinase 110;Inhibitor of tyrosine kinase with immunoglobulin like and EGF like domains 1;Inhibitor of unc-51 like autophagy

Item Number

N609522

Grouped product items
SKU	Size	Availability	Price	Qty
N609522-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
N609522-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Basic Description

Synonyms	compound R-16
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of interleukin 1 receptor associated kinase 3;Inhibitor of MET proto-oncogene; receptor tyrosine kinase;Inhibitor of sugen kinase 110;Inhibitor of tyrosine kinase with immunoglobulin like and EGF like domains 1;Inhibitor of unc-51 like autophagy

Names and Identifiers

IUPAC Name	N-[(3R)-8-[[5-chloro-4-[2-fluoro-6-(methylcarbamoyl)anilino]pyrimidin-2-yl]amino]-5,5-dimethyl-2-oxo-3,4-dihydro-1H-1-benzazepin-3-yl]pyrrolidine-1-carboxamide
INCHI	InChI=1S/C29H32ClFN8O3/c1-29(2)14-22(36-28(42)39-11-4-5-12-39)26(41)35-21-13-16(9-10-18(21)29)34-27-33-15-19(30)24(38-27)37-23-17(25(40)32-3)7-6-8-20(23)31/h6-10,13,15,22H,4-5,11-12,14H2,1-3H3,(H,32,40)(H,35,41)(H,36,42)(H2,33,34,37,38)/t22-/m1/s1
InChi Key	HGSNUBHWAMMKIR-JOCHJYFZSA-N
Canonical SMILES	CNC(=O)c1cccc(c1Nc1nc(ncc1Cl)Nc1ccc2c(c1)NC(=O)[C@@H](CC2(C)C)NC(=O)N1CCCC1)F
Isomeric SMILES	CC1(C[C@H](C(=O)NC2=C1C=CC(=C2)NC3=NC=C(C(=N3)NC4=C(C=CC=C4F)C(=O)NC)Cl)NC(=O)N5CCCC5)C
PubChem CID	56597775

ChEMBL Ligand

PubChem CID

References

1. Milkiewicz KL, Aimone LD, Albom MS, Angeles TS, Chang H, Grobelny JV, Husten J, Losardo C, Miknyoczki S, Murthy S et al.. (2011) Improvement in oral bioavailability of 2,4-diaminopyrimidine c-Met inhibitors by incorporation of a 3-amidobenzazepin-2-one group.. Bioorg Med Chem, 19 (21): (6274-84). [PMID:21967808]

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Basic Description