N-Boc-N-bis(PEG2-propargyl) is a branched PEG derivative with two terminal propargyl groups and a Boc protected amino group. The propargyl groups can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The amino group is reactive with carboxylic acids, activated NHS esters, and carbonyls. The protected amine can be deprotected by acidic conditions.