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N-Hydroxysuccinimide - 98%, high purity , CAS No.6066-82-6

  • ≥98%
Item Number
H109330
Grouped product items
SKUSizeAvailabilityPrice Qty
H109330-5g
5g
In stock
$9.90
H109330-25g
25g
In stock
$11.90
H109330-100g
100g
In stock
$15.90
H109330-500g
500g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$43.90
H109330-12×500g
12×500g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$469.90

Amine-reactive compound

Basic Description

SynonymsN-Hydroxysuccinimide|6066-82-6|1-hydroxypyrrolidine-2,5-dione|HOSu|1-Hydroxysuccinimide|Hydroxysuccinimide|1-Hydroxy-2,5-pyrrolidinedione|2,5-Pyrrolidinedione, 1-hydroxy-|Succinimide, N-hydroxy-|N-hydroxy succinimide|N-hydroxysuccinimide (HOSu)|MFCD000055
Specifications & Purity≥98%
Biochemical and Physiological MechanismsAmine-reactive compound. Used to modify, label and crosslink amine groups. Tool used for protein-protein interactions, N-terminal residue identification and the location of phosphorylated or O-glycosylated residues.
Storage TempStore at 2-8°C,Argon charged
Shipped InWet ice
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

N-Hydroxysuccinimide, commonly known as NHS, is a hydroxylated succinimide that is widely used in the activation of carboxylic acids to NHS-esters to promote coupling with nucleophiles. This approach is most commonly employed in activating the free acid forms of fluorophores for promoting conjugation of these fluorophores to amine residues of proteins. Use of NHS ester activation has also been described in the synthesis of N-acyl amino acids.
Useful in the carbodiimide method for improved amidations and peptide couplings.

Associated Targets

CRBN Tclin Protein cereblon 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TRPA1 Tclin Transient receptor potential cation channel subfamily A member 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Pubchem Sid488185823
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488185823
IUPAC Name 1-hydroxypyrrolidine-2,5-dione
INCHI InChI=1S/C4H5NO3/c6-3-1-2-4(7)5(3)8/h8H,1-2H2
InChi Key NQTADLQHYWFPDB-UHFFFAOYSA-N
Canonical SMILES C1CC(=O)N(C1=O)O
Isomeric SMILES C1CC(=O)N(C1=O)O
WGK Germany 3
PubChem CID 80170
Molecular Weight 115.09
Beilstein 113913
Reaxy-Rn 113913

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

48 results found

Lot NumberCertificate TypeDateItem
D2422317Certificate of AnalysisApr 12, 2024 H109330
D2422297Certificate of AnalysisApr 12, 2024 H109330
D2422296Certificate of AnalysisApr 12, 2024 H109330
D2422295Certificate of AnalysisApr 12, 2024 H109330
D2422094Certificate of AnalysisApr 12, 2024 H109330
C2429449Certificate of AnalysisMar 09, 2024 H109330
K2315289Certificate of AnalysisNov 02, 2023 H109330
K2315273Certificate of AnalysisNov 02, 2023 H109330
K2315272Certificate of AnalysisNov 02, 2023 H109330
H2330716Certificate of AnalysisAug 22, 2023 H109330
H2330423Certificate of AnalysisAug 22, 2023 H109330
H2330339Certificate of AnalysisAug 22, 2023 H109330
H2330338Certificate of AnalysisAug 22, 2023 H109330
H2330337Certificate of AnalysisAug 22, 2023 H109330
H2315476Certificate of AnalysisJul 06, 2023 H109330
H2315472Certificate of AnalysisJul 06, 2023 H109330
H2402064Certificate of AnalysisJul 06, 2023 H109330
G2321900Certificate of AnalysisJun 14, 2023 H109330
G2324045Certificate of AnalysisJun 14, 2023 H109330
G2321843Certificate of AnalysisJun 14, 2023 H109330
G2321834Certificate of AnalysisJun 14, 2023 H109330
G2321831Certificate of AnalysisJun 14, 2023 H109330
E2323667Certificate of AnalysisApr 20, 2023 H109330
E2323436Certificate of AnalysisApr 20, 2023 H109330
E2323421Certificate of AnalysisApr 20, 2023 H109330
E2323418Certificate of AnalysisApr 20, 2023 H109330
E2323446Certificate of AnalysisApr 20, 2023 H109330
D2301396Certificate of AnalysisMar 27, 2023 H109330
A2305195Certificate of AnalysisJan 16, 2023 H109330
B2308588Certificate of AnalysisJan 12, 2023 H109330
B2308604Certificate of AnalysisJan 12, 2023 H109330
B2308605Certificate of AnalysisJan 12, 2023 H109330
B2308606Certificate of AnalysisJan 12, 2023 H109330
B2308608Certificate of AnalysisJan 12, 2023 H109330
B2308611Certificate of AnalysisJan 12, 2023 H109330
B2308623Certificate of AnalysisJan 12, 2023 H109330
B2308631Certificate of AnalysisJan 12, 2023 H109330
D2320035Certificate of AnalysisJan 12, 2023 H109330
D2320037Certificate of AnalysisJan 12, 2023 H109330
K2203442Certificate of AnalysisSep 30, 2022 H109330
K2203443Certificate of AnalysisSep 30, 2022 H109330
K2203464Certificate of AnalysisSep 30, 2022 H109330
K2203481Certificate of AnalysisSep 30, 2022 H109330
K2203484Certificate of AnalysisSep 30, 2022 H109330
D2320036Certificate of AnalysisSep 30, 2022 H109330
C2208105Certificate of AnalysisNov 19, 2021 H109330
H2222302Certificate of AnalysisNov 19, 2021 H109330
H2222300Certificate of AnalysisNov 19, 2021 H109330

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Chemical and Physical Properties

SolubilitySoluble in water, dimethyl formamide, alcohols and ethyl acetate. Insoluble in cold ether.
SensitivityHeat & Moisture Sensitive.
Melt Point(°C)95-98°C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3
Reaxy-Rn 113913

Related Documents

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