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N,N'-Ethylenebis(iodoacetamide) - 95%, high purity , CAS No.7250-43-3

  • ≥95%
Item Number
N276531
Grouped product items
SKUSizeAvailabilityPrice Qty
N276531-25mg
25mg
1
$189.90
N276531-100mg
100mg
1
$463.90

Tubulin conformational state probe.

Basic Description

Synonyms2-iodo-N-[2-[(2-iodoacetyl)amino]ethyl]acetamide | Ethylenediamine bis(iodoacetamide) | N,N'-1,2-Ethanediylbis(2-iodoacetamide)
Specifications & Purity≥95%
Biochemical and Physiological MechanismsHomobifunctional sulfhydryl-reactive crosslinker. Used as a probe for the conformational state of free tubulin molecules. Reacts specifically with the sulfhydryl groups.
Storage TempProtected from light,Store at -20°C,Argon charged,Desiccated
Shipped InIce chest + Ice pads
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.


product description:

Unstable in DMSO


application:

Used as a probe for the conformational state of the tubulin molecule. It reacts specifically with the sulfhydryl groups in tubulin.


AI Insight

Mechanisms of Action

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Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid504753138
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504753138
IUPAC Name 2-iodo-N-[2-[(2-iodoacetyl)amino]ethyl]acetamide
INCHI InChI=1S/C6H10I2N2O2/c7-3-5(11)9-1-2-10-6(12)4-8/h1-4H2,(H,9,11)(H,10,12)
InChi Key RLFPCLMBTQOMLI-UHFFFAOYSA-N
Canonical SMILES C(CNC(=O)CI)NC(=O)CI
Isomeric SMILES C(CNC(=O)CI)NC(=O)CI
PubChem CID 23678
Molecular Weight 395.96

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot NumberCertificate TypeDateItem
C2405574Certificate of AnalysisDec 09, 2024 N276531
C2405575Certificate of AnalysisDec 09, 2024 N276531
C2405576Certificate of AnalysisDec 09, 2024 N276531
G2314183Certificate of AnalysisMay 10, 2024 N276531
L2301130Certificate of AnalysisSep 20, 2023 N276531
B2223557Certificate of AnalysisDec 12, 2022 N276531
B2223666Certificate of AnalysisFeb 12, 2022 N276531

Chemical and Physical Properties

SolubilitySlightly soluble in DMSO or Dichloromethane. Soluble in methanol.
SensitivitySensitive to light; sensitive to heat
Melt Point(°C)>178°C
Molecular Weight395.960 g/mol
XLogP30.200
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count5
Exact Mass395.883 Da
Monoisotopic Mass395.883 Da
Topological Polar Surface Area58.200 Ų
Heavy Atom Count12
Formal Charge0
Complexity146.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1

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References

1. Atanasov G et al..  (2021)  New Heterocyclic Combretastatin A-4 Analogs: Synthesis and Biological Activity of Styryl-2(3H)-benzothiazolones..  Pharmaceuticals (Basel),  14  (12):   [PMID:34959731]

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