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SKU | Size | Availability | Price | Qty |
---|---|---|---|---|
N276531-25mg | 25mg | 1 | $189.90 | |
N276531-100mg | 100mg | 1 | $463.90 |
Tubulin conformational state probe.
Synonyms | 2-iodo-N-[2-[(2-iodoacetyl)amino]ethyl]acetamide | Ethylenediamine bis(iodoacetamide) | N,N'-1,2-Ethanediylbis(2-iodoacetamide) |
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Specifications & Purity | ≥95% |
Biochemical and Physiological Mechanisms | Homobifunctional sulfhydryl-reactive crosslinker. Used as a probe for the conformational state of free tubulin molecules. Reacts specifically with the sulfhydryl groups. |
Storage Temp | Protected from light,Store at -20°C,Argon charged,Desiccated |
Shipped In | Ice chest + Ice pads |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. product description: Unstable in DMSO application: Used as a probe for the conformational state of the tubulin molecule. It reacts specifically with the sulfhydryl groups in tubulin. |
Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Pubchem Sid | 504753138 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504753138 |
IUPAC Name | 2-iodo-N-[2-[(2-iodoacetyl)amino]ethyl]acetamide |
INCHI | InChI=1S/C6H10I2N2O2/c7-3-5(11)9-1-2-10-6(12)4-8/h1-4H2,(H,9,11)(H,10,12) |
InChi Key | RLFPCLMBTQOMLI-UHFFFAOYSA-N |
Canonical SMILES | C(CNC(=O)CI)NC(=O)CI |
Isomeric SMILES | C(CNC(=O)CI)NC(=O)CI |
PubChem CID | 23678 |
Molecular Weight | 395.96 |
Find and download the COA for your product by matching the lot number on the packaging.
7 results found
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
Certificate of Analysis | Dec 09, 2024 | N276531 | |
Certificate of Analysis | Dec 09, 2024 | N276531 | |
Certificate of Analysis | Dec 09, 2024 | N276531 | |
Certificate of Analysis | May 10, 2024 | N276531 | |
Certificate of Analysis | Sep 20, 2023 | N276531 | |
Certificate of Analysis | Dec 12, 2022 | N276531 | |
Certificate of Analysis | Feb 12, 2022 | N276531 |
Solubility | Slightly soluble in DMSO or Dichloromethane. Soluble in methanol. |
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Sensitivity | Sensitive to light; sensitive to heat |
Melt Point(°C) | >178°C |
Molecular Weight | 395.960 g/mol |
XLogP3 | 0.200 |
Hydrogen Bond Donor Count | 2 |
Hydrogen Bond Acceptor Count | 2 |
Rotatable Bond Count | 5 |
Exact Mass | 395.883 Da |
Monoisotopic Mass | 395.883 Da |
Topological Polar Surface Area | 58.200 Ų |
Heavy Atom Count | 12 |
Formal Charge | 0 |
Complexity | 146.000 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
The total count of all stereochemical bonds | 0 |
Covalently-Bonded Unit Count | 1 |
1. Atanasov G et al.. (2021) New Heterocyclic Combretastatin A-4 Analogs: Synthesis and Biological Activity of Styryl-2(3H)-benzothiazolones.. Pharmaceuticals (Basel), 14 (12): [PMID:34959731] |