N-Nornuciferine - 99%, high purity , CAS No.4846-19-9

Item Number

N649111

Grouped product items
SKU	Size	Availability	Price	Qty
N649111-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$210.90
N649111-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$360.90

Alkaloids Isoquinoline Alkaloids

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Basic Description

Synonyms	N-Nornuciferine\|4846-19-9\|(R)-Nornuciferine\|Daechualkaloid E\|(6aR)-1,2-dimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline\|1,2-Dimethoxynoraporphine\|Sanjoinine Ia\|N-Desmethylnuciferine\|6a.beta.-Noraporphine, 1,2-dimethoxy-\|CHEMBL1164391\|QQKAHDMMPBQDAC
Specifications & Purity	99%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	N-Nornuciferine is an aporphine alkaloid in lotus leaf that significantly inhibits CYP2D6 with IC 50 and K i of 3.76 and 2.34 μM, respectively. In Vitro The herb of lotus leaves is a commonly used traditional Chinese medicine with a wide range of pharmacological and physiological activities, particularly the reduction of the blood triglyceride and cholesterol levels. N-Nornuciferine strongly inhibits CYP2D6 activity but shows weak or no inhibition of the other four P450 isoenzymes (CYP2C19, CYP3A4, CYP2E1, CYP2C9). N-Nornuciferine competitively inhibits the CYP2D6-catalyzed dextromethorphan o-demethylation with apparent K i values of 2.34 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:CYP2

Names and Identifiers

IUPAC Name	(6aR)-1,2-dimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline
INCHI	InChI=1S/C18H19NO2/c1-20-15-10-12-7-8-19-14-9-11-5-3-4-6-13(11)17(16(12)14)18(15)21-2/h3-6,10,14,19H,7-9H2,1-2H3/t14-/m1/s1
InChi Key	QQKAHDMMPBQDAC-CQSZACIVSA-N
Canonical SMILES	COC1=C(C2=C3C(CC4=CC=CC=C42)NCCC3=C1)OC
Isomeric SMILES	COC1=C(C2=C3[C@@H](CC4=CC=CC=C42)NCCC3=C1)OC
PubChem CID	12313579
Molecular Weight	281.3

Safety and Hazards(GHS)

Pictogram(s)	GHS06
Signal	Danger
Hazard Statements	H301:Toxic if swallowed H311:Toxic in contact with skin H331:Toxic if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P330:Rinse mouth. P361+P364:Take off immediately all contaminated clothing and wash it before reuse. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P316:Get emergency medical help immediately.

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Basic Description