| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| N655713-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $231.90 |
Alkaloids Isoquinoline Alkaloids
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | N-Nornuciferine is an aporphine alkaloid in lotus leaf that significantly inhibits CYP2D6 with IC 50 and K i of 3.76 and 2.34 μM, respectively. In Vitro The herb of lotus leaves is a commonly used traditional Chinese medicine with a wide range of pharmacological and physiological activities, particularly the reduction of the blood triglyceride and cholesterol levels. N-Nornuciferine strongly inhibits CYP2D6 activity but shows weak or no inhibition of the other four P450 isoenzymes (CYP2C19, CYP3A4, CYP2E1, CYP2C9). N-Nornuciferine competitively inhibits the CYP2D6-catalyzed dextromethorphan o-demethylation with apparent K i values of 2.34 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:CYP2 |
| Canonical SMILES | COC1=C(C2=C3C(CC4=CC=CC=C42)NCCC3=C1)OC |
|---|---|
| Molecular Weight | 281.3 |
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