N-piperidine Ibrutinib hydrochloride - 95%, high purity , CAS No.2231747-18-3

Item Number

N647195

Grouped product items
SKU	Size	Availability	Price
N647195-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,140.90
N647195-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$224.90
N647195-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$448.90
N647195-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$716.90
N647195-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$140.90

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Basic Description

Specifications & Purity	95%
Storage Temp	Protected from light,Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads
Product Description	N-piperidine Ibrutinib hydrochloride (Compound 1) is a reversible Ibrutinib derivative. N-piperidine Ibrutinib hydrochloride is a potent BTK inhibitor with IC 50 s of 51.0 and 30.7 nM for WT BTK and C481S BTK , respectively N-piperidine Ibrutinib hydrochloride can be used as a BTK ligand in the synthesis of a series of PROTACs , such as SJF620 ( HY-133137 ). SJF620 is a potent PROTAC BTK degrader with a DC 50 of 7.9 nM . In Vitro N-piperidine Ibrutinib hydrochloride can be used as a BTK ligand in the synthesis of a series of PROTACs. SJF638, SJF678, and SJF608 are potent PROTAC BTK degraders with DC 50 s of 374, 162, and 8.3 nM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 51.0 nM (WT BTK), 30.7 nM (C481S BTK)

Names and Identifiers

IUPAC Name	3-(4-phenoxyphenyl)-1-piperidin-4-ylpyrazolo[3,4-d]pyrimidin-4-amine;hydrochloride
INCHI	InChI=1S/C22H22N6O.ClH/c23-21-19-20(15-6-8-18(9-7-15)29-17-4-2-1-3-5-17)27-28(22(19)26-14-25-21)16-10-12-24-13-11-16;/h1-9,14,16,24H,10-13H2,(H2,23,25,26);1H
InChi Key	ORBFZIXZKIUECG-UHFFFAOYSA-N
Canonical SMILES	C1CNCCC1N2C3=NC=NC(=C3C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)N.Cl
PubChem CID	139465991
Molecular Weight	422.91

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Basic Description