| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| N654912-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $154.90 |
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Storage Temp | Protected from light,Desiccated,Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | N-piperidine Ibrutinib hydrochloride (Compound 1) is a reversible Ibrutinib derivative. N-piperidine Ibrutinib hydrochloride is a potent BTK inhibitor with IC 50 s of 51.0 and 30.7 nM for WT BTK and C481S BTK , respectively N-piperidine Ibrutinib hydrochloride can be used as a BTK ligand in the synthesis of a series of PROTACs , such as SJF620 ( HY-133137 ). SJF620 is a potent PROTAC BTK degrader with a DC 50 of 7.9 nM . In Vitro N-piperidine Ibrutinib hydrochloride can be used as a BTK ligand in the synthesis of a series of PROTACs. SJF638, SJF678, and SJF608 are potent PROTAC BTK degraders with DC 50 s of 374, 162, and 8.3 nM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 51.0 nM (WT BTK), 30.7 nM (C481S BTK) |
| Canonical SMILES | C1CNCCC1N2C3=NC=NC(=C3C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)N.Cl |
|---|---|
| Molecular Weight | 422.91 |
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