N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide - 97%, high purity , CAS No.77377-52-7

2 Citations
  • ≥97%
Item Number
N433876
Grouped product items
SKUSizeAvailabilityPrice Qty
N433876-5ml
5ml
In stock
$123.90
N433876-25ml
25ml
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$432.90
N433876-100ml
100ml
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,209.90
View related series
Silylacetamide Silylation Reagents

Basic Description

SynonymsAcetamide, N-((1,1-dimethylethyl)dimethylsilyl)-2,2,2-trifluoro-N-methyl- | Acetamide, N-[(1,1-dimethylethyl)dimethylsilyl]-2,2,2-trifluoro-N-methyl- | n-methyl-n-t-butyldimethylsilyltrifluoroacetamide | SY049326 | N-tert-Butyldimethylsilyl-N-methyltriflu
Specifications & Purity≥97%
Storage TempStore at 2-8°C,Argon charged
Shipped InWet ice
Product Description

Application

N - tert -butyldimethylsilyl- N -methyltrifluoroacetamide (MTBSTFA) can be used as an efficient silylating agent for different alcohols, thiols, phenols, carboxylic acids, amines, and amides. It can also be used to functionalize multi-walled carbon nanotubes (MWCNTs) with polar groups. MTBSTFA is reportedly much less moisture-sensitive than other silylating reagents used for GLC derivatization.

Names and Identifiers

IUPAC Name N-[tert-butyl(dimethyl)silyl]-2,2,2-trifluoro-N-methylacetamide
INCHI InChI=1S/C9H18F3NOSi/c1-8(2,3)15(5,6)13(4)7(14)9(10,11)12/h1-6H3
InChi Key QRKUHYFDBWGLHJ-UHFFFAOYSA-N
Canonical SMILES CC(C)(C)[Si](C)(C)N(C)C(=O)C(F)(F)F
Isomeric SMILES CC(C)(C)[Si](C)(C)N(C)C(=O)C(F)(F)F
WGK Germany 3
PubChem CID 2724275
Molecular Weight 241.33
Beilstein 3606546

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot NumberCertificate TypeDateItem
C2413057Certificate of AnalysisOct 20, 2023 N433876
G2404037Certificate of AnalysisOct 20, 2023 N433876
H2421031Certificate of AnalysisOct 20, 2023 N433876
K2306324Certificate of AnalysisOct 20, 2023 N433876
K2306342Certificate of AnalysisOct 20, 2023 N433876
K2306343Certificate of AnalysisOct 20, 2023 N433876
K2306344Certificate of AnalysisOct 20, 2023 N433876
K2306345Certificate of AnalysisOct 20, 2023 N433876

Chemical and Physical Properties

SensitivityMoisture sensitive
Refractive Index1.402
Flash Point(°F)52℃(125°F)
Flash Point(°C)52℃(125°F)
Boil Point(°C)168-170°C

Safety and Hazards(GHS)

Pictogram(s) GHS07,   GHS02
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H226:Flammable liquid and vapor

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378:In case of fire: Use ... to extinguish.

P210:Keep away from heat, hot surface, sparks, open flames and other ignition sources. - No smoking.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P233:Keep container tightly closed.

P240:Ground/bond container and receiving equipment.

P264:Wash hands [and …] thoroughly after handling.

P403+P235:Store in a well-ventilated place. Keep cool.

P303+P361+P353:IF ON SKIN (or hair): Take off Immediately all contaminated clothing. Rinse SKIN with water [or shower].

P271:Use only outdoors or in a well-ventilated area.

P241:Use explosion-proof [electrical/ventilating/lighting/.../] equipment.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P242:Use only non-sparking tools.

P243:Take precautionary measures against static discharge.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3

Related Documents

Citations of This Product

1. Can Xie, Wei Ni, Fei Liu, Gangtian Zhu, Yuguang Hou.  (2023)  Analysis, distribution and evolution of individual carboxylic acids in crude oil during biodegradation.  ORGANIC GEOCHEMISTRY,  178  (104573).  [PMID:]
2. Wei Ni, Gangtian Zhu, Fei Liu, Can Xie, Wei Li, Shukui Zhu.  (2022)  Rapid profiling of carboxylic acids in reservoir biodegraded crude oils using gas purge microsyringe extraction coupled to comprehensive two-dimensional gas chromatography-mass spectrometry.  FUEL,  316  (123312).  [PMID:]
3. Xuejing Li, Yan Hui, Bingfeng Leng, Junli Ren, Yanni Song, Lianqiang Che, Xi Peng, Baojia Huang, Songling Liu, Lin Li, Dennis Sandris Nielsen, Yong Li, Xiaoshuang Dai, Shancen Zhao.  (2021)  Millet-based supplement restored gut microbial diversity of acute malnourished pigs.  PLoS One,  16  (4): (e0250423).  [PMID:33914799]
4. Gangtian Zhu, Fei Liu, Peiyang Li, Sheng He, Shukui Zhu, Qiang Gao, Yuqi Feng.  (2019)  Profiling free fatty acids in edible oils via magnetic dispersive extraction and comprehensive two-dimensional gas chromatography-mass spectrometry.  FOOD CHEMISTRY,  297  (124998).  [PMID:31253278]

References

1. Teemu Gunnar,Kari Ariniemi,Pirjo Lillsunde.  (2005-03-01)  Determination of 14 benzodiazepines and hydroxy metabolites, zaleplon and zolpidem as tert-butyldimethylsilyl derivatives compared with other common silylating reagents in whole blood by gas chromatography-mass spectrometry..  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,  818  ((2)): (175-189).  [PMID:15734157]
2. Man-Jeong Paik,Hong-Jin Lee,Kyoung-Rae Kim.  (2005-05-17)  Simultaneous retention index analysis of urinary amino acids and carboxylic acids for graphic recognition of abnormal state..  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,  821  ((1)): (94-104).  [PMID:15894518]
3. Paul L Wood,M Amin Khan,Joseph R Moskal.  (2006-01-13)  Neurochemical analysis of amino acids, polyamines and carboxylic acids: GC-MS quantitation of tBDMS derivatives using ammonia positive chemical ionization..  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,  831  ((1-2)): (313-319).  [PMID:16406747]
4. A Royer,F Laporte,S Bouchonnet,P-Y Communal.  (2006-01-31)  Determination of ethephon residues in water by gas chromatography with cubic mass spectrometry after ion-exchange purification and derivatisation with N-(tert-butyldimethylsilyl)-N-methyltrifluoroacetamide..  Journal of chromatography. A,  1108  ((1)): (129-135).  [PMID:16443233]
5. Ali Shareef,Michael J Angove,John D Wells.  (2006-02-01)  Optimization of silylation using N-methyl-N-(trimethylsilyl)-trifluoroacetamide, N,O-bis-(trimethylsilyl)-trifluoroacetamide and N-(tert-butyldimethylsilyl)-N-methyltrifluoroacetamide for the determination of the estrogens estrone and 17alpha-ethinylestradiol by gas chromatography-mass spectrometry..  Journal of chromatography. A,  1108  ((1)): (121-128).  [PMID:16445920]
6. Stuart J Khan,Howard S Weinberg,E Cydnie Bedford.  (2006-04-18)  Aqueous-phase aminolysis: approach for the analysis of epoxides in water..  Analytical chemistry,  78  ((8)): (2608-2616).  [PMID:16615770]
7. Lourdes Bosch,Maria Luz Sanz,Antonia Montilla,Amparo Alegría,Rosaura Farré,María Dolores del Castillo.  (2007-11-13)  Simultaneous analysis of lysine, Nepsilon-carboxymethyllysine and lysinoalanine from proteins..  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,  860  ((1)): (69-77).  [PMID:17997368]
8. Xiaodong Huang,Fred E Regnier.  (2007-12-07)  Differential metabolomics using stable isotope labeling and two-dimensional gas chromatography with time-of-flight mass spectrometry..  Analytical chemistry,  80  ((1)): (107-114).  [PMID:18052339]
9. Yi-Ping Pan,Shih-Wei Tsai.  (2008-08-19)  Solid phase microextraction procedure for the determination of alkylphenols in water by on-fiber derivatization with N-tert-butyl-dimethylsilyl-N-methyltrifluoroacetamide..  Analytica chimica acta,  624  ((2)): (247-252).  [PMID:18706331]
10. José Angel Prieto,Fernando Andrade,Sergio Martín,Pablo Sanjurjo,Javier Elorz,Luís Aldámiz-Echevarría.  (2008-11-11)  Determination of creatine and guanidinoacetate by GC-MS: study of their stability in urine at different temperatures..  Clinical biochemistry,  42  ((1-2)): (125-128).  [PMID:18992235]
11. R Montes,I Rodríguez,E Rubí,R Cela.  (2008-12-17)  Dispersive liquid-liquid microextraction applied to the simultaneous derivatization and concentration of triclosan and methyltriclosan in water samples..  Journal of chromatography. A,  1216  ((2)): (205-210).  [PMID:19084234]
12. Claude Schummer,Olivier Delhomme,Brice M R Appenzeller,Robert Wennig,Maurice Millet.  (2008-12-17)  Comparison of MTBSTFA and BSTFA in derivatization reactions of polar compounds prior to GC/MS analysis..  Talanta,  77  ((4)): (1473-1482).  [PMID:19084667]
13. Xiaowei Wang,Lijuan Luo,Gangfeng Ouyang,Li Lin,Nora F Y Tam,Chongyu Lan,Tiangang Luan.  (2009-07-31)  One-step extraction and derivatization liquid-phase microextraction for the determination of chlorophenols by gas chromatography-mass spectrometry..  Journal of chromatography. A,  1216  ((35)): (6267-6273).  [PMID:19640544]
14. Martin Adiels,Thomas Larsson,Pauline Sutton,Marja-Riitta Taskinen,Jan Borén,Barbara A Fielding.  (2010-02-09)  Optimization of N-methyl-N-[tert-butyldimethylsilyl]trifluoroacetamide as a derivatization agent for determining isotopic enrichment of glycerol in very-low density lipoproteins..  Rapid communications in mass spectrometry : RCM,  24  ((5)): (586-592).  [PMID:20140976]
15. Caroline Raeppel,Marie Nief,Marie Fabritius,Lucie Racault,Brice M Appenzeller,Maurice Millet.  (2011-10-04)  Simultaneous analysis of pesticides from different chemical classes by using a derivatisation step and gas chromatography-mass spectrometry..  Journal of chromatography. A,  1218  ((44)): (8123-8129).  [PMID:21962330]
16. David Saraiva,Rute Semedo,Maria da Conceição Castilho,José Manuel Silva,Fernando Ramos.  (2011-11-18)  Selection of the derivatization reagent--the case of human blood cholesterol, its precursors and phytosterols GC-MS analyses..  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,  879  ((32)): (3806-3811).  [PMID:22088355]
17. Yong Yu,Laosheng Wu.  (2012-01-31)  Analysis of endocrine disrupting compounds, pharmaceuticals and personal care products in sewage sludge by gas chromatography-mass spectrometry..  Talanta,  89  (258-263).  [PMID:22284489]
18. Xiaowei Wang,Li Lin,Tiangang Luan,Lihua Yang,Nora F Y Tam.  (2012-10-31)  Determination of hydroxylated metabolites of polycyclic aromatic hydrocarbons in sediment samples by combining subcritical water extraction and dispersive liquid-liquid microextraction with derivatization..  Analytica chimica acta,  753  (57-63).  [PMID:23107137]
19. Valentina Manzo,Luis Honda,Orielle Navarro,Loreto Ascar,Pablo Richter.  (2014-07-26)  Microextraction of non-steroidal anti-inflammatory drugs from waste water samples by rotating-disk sorptive extraction..  Talanta,  128  (486-492).  [PMID:25059190]
20. Anna Topolewska,Karolina Czarnowska,Łukasz P Haliński,Piotr Stepnowski.  (2015-04-16)  Evaluation of four derivatization methods for the analysis of fatty acids from green leafy vegetables by gas chromatography..  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,  990  (150-157).  [PMID:25875587]
21. Tian-Xiang Wang,Jun-Yun Liang,Cheng Zhang,Yue Xiong,Kun-Liang Guan,Hai-Xin Yuan.  (2019-10-09)  The oncometabolite 2-hydroxyglutarate produced by mutant IDH1 sensitizes cells to ferroptosis..  Cell death & disease,  10  ((10)): (755-755).  [PMID:31591388]
22. Celia M Bisbach,Daniel T Hass,Brian M Robbings,Austin M Rountree,Martin Sadilek,Ian R Sweet,James B Hurley.  (2020-05-07)  Succinate Can Shuttle Reducing Power from the Hypoxic Retina to the O2-Rich Pigment Epithelium..  Cell reports,  31  ((5)): (107606-107606).  [PMID:32375026]
23. Stephane Morville,Anne Scheyer,Philippe Mirabel,Maurice Millet.  (2004-11-30)  A multiresidue method for the analysis of phenols and nitrophenols in the atmosphere..  Journal of environmental monitoring : JEM,  ((12)): (963-966).  [PMID:15568044]
24. P Canosa,I Rodriguez,E Rubí,R Cela.  (2005-05-11)  Optimization of solid-phase microextraction conditions for the determination of triclosan and possible related compounds in water samples..  Journal of chromatography. A,  1072  ((1)): (107-115).  [PMID:15881465]
25. Isaac Ohsawa,Yasuo Seto.  (2006-05-19)  Determination of nitrogen mustard hydrolysis products, ethanolamines by gas chromatography-mass spectrometry after tert-butyldimethylsilyl derivatization..  Journal of chromatography. A,  1122  ((1-2)): (242-248).  [PMID:16707130]
26. Bill Guthery,Alan Bassindale,Colin T Pillinger,Geraint H Morgan.  (2009-01-07)  The detection of various opiates and benzodiazepines by comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry..  Rapid communications in mass spectrometry : RCM,  23  ((3)): (340-348).  [PMID:19125414]
27. Ho-Sang Shin,Hyun-Hee Lim.  (2011-02-01)  Simultaneous determination of 2-naphthol and 1-hydroxy pyrene in urine by gas chromatography-mass spectrometry..  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,  879  ((7-8)): (489-494).  [PMID:21277841]
28. Branka Šošić-Jurjević,Branko Filipović,Eva Katrin Wirth,Jasmina Živanović,Niko Radulović,Snežana Janković,Verica Milošević,Josef Köhrle.  (2014-05-06)  Soy isoflavones interfere with thyroid hormone homeostasis in orchidectomized middle-aged rats..  Toxicology and applied pharmacology,  278  ((2)): (124-134).  [PMID:24793811]
29. Thomas M Wasylenko,Gregory Stephanopoulos.  (2014-10-15)  Metabolomic and (13)C-metabolic flux analysis of a xylose-consuming Saccharomyces cerevisiae strain expressing xylose isomerase..  Biotechnology and bioengineering,  112  ((3)): (470-483).  [PMID:25311863]
30. T Schettgen,A Alt,P Dewes,T Kraus.  (2015-06-06)  Simple and sensitive GC/MS-method for the quantification of urinary phenol, o- and m-cresol and ethylphenols as biomarkers of exposure to industrial solvents..  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,  995-996  (93-100).  [PMID:26046979]
31. Can Xie, Wei Ni, Fei Liu, Gangtian Zhu, Yuguang Hou.  (2023)  Analysis, distribution and evolution of individual carboxylic acids in crude oil during biodegradation.  ORGANIC GEOCHEMISTRY,  178  (104573).  [PMID:]
32. Wei Ni, Gangtian Zhu, Fei Liu, Can Xie, Wei Li, Shukui Zhu.  (2022)  Rapid profiling of carboxylic acids in reservoir biodegraded crude oils using gas purge microsyringe extraction coupled to comprehensive two-dimensional gas chromatography-mass spectrometry.  FUEL,  316  (123312).  [PMID:]
33. Xuejing Li, Yan Hui, Bingfeng Leng, Junli Ren, Yanni Song, Lianqiang Che, Xi Peng, Baojia Huang, Songling Liu, Lin Li, Dennis Sandris Nielsen, Yong Li, Xiaoshuang Dai, Shancen Zhao.  (2021)  Millet-based supplement restored gut microbial diversity of acute malnourished pigs.  PLoS One,  16  (4): (e0250423).  [PMID:33914799]
34. Gangtian Zhu, Fei Liu, Peiyang Li, Sheng He, Shukui Zhu, Qiang Gao, Yuqi Feng.  (2019)  Profiling free fatty acids in edible oils via magnetic dispersive extraction and comprehensive two-dimensional gas chromatography-mass spectrometry.  FOOD CHEMISTRY,  297  (124998).  [PMID:31253278]

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