Call +1 (833) 552-7181 or Contact us Earn $25 in coupons on your first order with Aladdin!
Toggle Nav
My Cart
Search
Advanced Search
Menu
Sign In
྾
main product photo

N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide with 1% tert-Butyldimethylchlorosilane - ≥95%, high purity , CAS No.77377-52-7

  • ≥95%
Item Number
N433877
Grouped product items
SKUSizeAvailabilityPrice Qty
N433877-5ml
5ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$379.90
N433877-10×1ml
10×1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$440.90
N433877-25ml
25ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$878.90
Add to Wish List Compare
Bulk Order  SDS  DATASHEET

Basic Description

Synonyms77377-52-7 | Mtbstfa | N-(tert-Butyldimethylsilyl)-N-methyltrifluoroacetamide | n-(tert-butyldimethylsilyl)-n-methyl-trifluoroacetamide | N-(tert-butyldimethylsilyl)-2,2,2-trifluoro-N-methylacetamide | N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide | N-methyl-N
Specifications & Purity≥95%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Product Description

Application

N - tert -Butyldimethylsilyl- N -methyltrifluoroacetamide with 1% tert -butyldimethylchlorosilane is commonly used for the preparation of N - tert -butyldimethylsilyl ethanolamines resulting from the hydrolysis of nitrogen mustards. It is also used for selective O -silylation of N , O -diacylhydroxyl amines.

Names and Identifiers

IUPAC Name N-[tert-butyl(dimethyl)silyl]-2,2,2-trifluoro-N-methylacetamide
INCHI InChI=1S/C9H18F3NOSi/c1-8(2,3)15(5,6)13(4)7(14)9(10,11)12/h1-6H3
InChi Key QRKUHYFDBWGLHJ-UHFFFAOYSA-N
Canonical SMILES CC(C)(C)[Si](C)(C)N(C)C(=O)C(F)(F)F
Isomeric SMILES CC(C)(C)[Si](C)(C)N(C)C(=O)C(F)(F)F
WGK Germany 3
PubChem CID 2724275
Molecular Weight 241.33
Beilstein 3606546

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Chemical and Physical Properties

Refractive Index1.402
Flash Point(°F)52℃(125°F)
Flash Point(°C)52℃(125°F)
Boil Point(°C)168-170°C

Safety and Hazards(GHS)

Pictogram(s) GHS07,   GHS02
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H226:Flammable liquid and vapor

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378:In case of fire: Use ... to extinguish.

P210:Keep away from heat, hot surface, sparks, open flames and other ignition sources. - No smoking.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P233:Keep container tightly closed.

P240:Ground/bond container and receiving equipment.

P264:Wash hands [and …] thoroughly after handling.

P403+P235:Store in a well-ventilated place. Keep cool.

P303+P361+P353:IF ON SKIN (or hair): Take off Immediately all contaminated clothing. Rinse SKIN with water [or shower].

P271:Use only outdoors or in a well-ventilated area.

P241:Use explosion-proof [electrical/ventilating/lighting/.../] equipment.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P242:Use only non-sparking tools.

P243:Take precautionary measures against static discharge.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3

Related Documents

 SDS

 Specification Sheet

Citations of This Product

1. Can Xie, Wei Ni, Fei Liu, Gangtian Zhu, Yuguang Hou.  (2023)  Analysis, distribution and evolution of individual carboxylic acids in crude oil during biodegradation.  ORGANIC GEOCHEMISTRY,  178  (104573).  [PMID:]
2. Wei Ni, Gangtian Zhu, Fei Liu, Can Xie, Wei Li, Shukui Zhu.  (2022)  Rapid profiling of carboxylic acids in reservoir biodegraded crude oils using gas purge microsyringe extraction coupled to comprehensive two-dimensional gas chromatography-mass spectrometry.  FUEL,  316  (123312).  [PMID:]

References

1. Man-Jeong Paik,Hong-Jin Lee,Kyoung-Rae Kim.  (2005-05-17)  Simultaneous retention index analysis of urinary amino acids and carboxylic acids for graphic recognition of abnormal state..  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,  821  ((1)): (94-104).  [PMID:15894518]
2. Paul L Wood,M Amin Khan,Joseph R Moskal.  (2006-01-13)  Neurochemical analysis of amino acids, polyamines and carboxylic acids: GC-MS quantitation of tBDMS derivatives using ammonia positive chemical ionization..  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,  831  ((1-2)): (313-319).  [PMID:16406747]
3. A Royer,F Laporte,S Bouchonnet,P-Y Communal.  (2006-01-31)  Determination of ethephon residues in water by gas chromatography with cubic mass spectrometry after ion-exchange purification and derivatisation with N-(tert-butyldimethylsilyl)-N-methyltrifluoroacetamide..  Journal of chromatography. A,  1108  ((1)): (129-135).  [PMID:16443233]
4. Ali Shareef,Michael J Angove,John D Wells.  (2006-02-01)  Optimization of silylation using N-methyl-N-(trimethylsilyl)-trifluoroacetamide, N,O-bis-(trimethylsilyl)-trifluoroacetamide and N-(tert-butyldimethylsilyl)-N-methyltrifluoroacetamide for the determination of the estrogens estrone and 17alpha-ethinylestradiol by gas chromatography-mass spectrometry..  Journal of chromatography. A,  1108  ((1)): (121-128).  [PMID:16445920]
5. Lourdes Bosch,Maria Luz Sanz,Antonia Montilla,Amparo Alegría,Rosaura Farré,María Dolores del Castillo.  (2007-11-13)  Simultaneous analysis of lysine, Nepsilon-carboxymethyllysine and lysinoalanine from proteins..  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,  860  ((1)): (69-77).  [PMID:17997368]
6. Xiaodong Huang,Fred E Regnier.  (2007-12-07)  Differential metabolomics using stable isotope labeling and two-dimensional gas chromatography with time-of-flight mass spectrometry..  Analytical chemistry,  80  ((1)): (107-114).  [PMID:18052339]
7. Yi-Ping Pan,Shih-Wei Tsai.  (2008-08-19)  Solid phase microextraction procedure for the determination of alkylphenols in water by on-fiber derivatization with N-tert-butyl-dimethylsilyl-N-methyltrifluoroacetamide..  Analytica chimica acta,  624  ((2)): (247-252).  [PMID:18706331]
8. José Angel Prieto,Fernando Andrade,Sergio Martín,Pablo Sanjurjo,Javier Elorz,Luís Aldámiz-Echevarría.  (2008-11-11)  Determination of creatine and guanidinoacetate by GC-MS: study of their stability in urine at different temperatures..  Clinical biochemistry,  42  ((1-2)): (125-128).  [PMID:18992235]
9. R Montes,I Rodríguez,E Rubí,R Cela.  (2008-12-17)  Dispersive liquid-liquid microextraction applied to the simultaneous derivatization and concentration of triclosan and methyltriclosan in water samples..  Journal of chromatography. A,  1216  ((2)): (205-210).  [PMID:19084234]
10. Claude Schummer,Olivier Delhomme,Brice M R Appenzeller,Robert Wennig,Maurice Millet.  (2008-12-17)  Comparison of MTBSTFA and BSTFA in derivatization reactions of polar compounds prior to GC/MS analysis..  Talanta,  77  ((4)): (1473-1482).  [PMID:19084667]
11. Xiaowei Wang,Lijuan Luo,Gangfeng Ouyang,Li Lin,Nora F Y Tam,Chongyu Lan,Tiangang Luan.  (2009-07-31)  One-step extraction and derivatization liquid-phase microextraction for the determination of chlorophenols by gas chromatography-mass spectrometry..  Journal of chromatography. A,  1216  ((35)): (6267-6273).  [PMID:19640544]
12. Martin Adiels,Thomas Larsson,Pauline Sutton,Marja-Riitta Taskinen,Jan Borén,Barbara A Fielding.  (2010-02-09)  Optimization of N-methyl-N-[tert-butyldimethylsilyl]trifluoroacetamide as a derivatization agent for determining isotopic enrichment of glycerol in very-low density lipoproteins..  Rapid communications in mass spectrometry : RCM,  24  ((5)): (586-592).  [PMID:20140976]
13. Philip A Smith,Vilmar Villa,Gregory L King.  (2010-07-14)  Artifacts related to N-methyl-N-(tert-butyldimethylsilyl)trifluoroacetamide derivatization of citrulline revealed by gas chromatography-mass spectrometry using both electron and chemical ionization..  Journal of chromatography. A,  1217  ((33)): (5444-5448).  [PMID:20621299]
14. Eva C Hartmann,Julia M Latzin,Birgit K Schindler,Holger M Koch,Jürgen Angerer.  (2010-10-19)  Excretion of 2,3-dihydroxy-propionamide (OH-PA), the hydrolysis product of glycidamide, in human urine after single oral dose of deuterium-labeled acrylamide..  Archives of toxicology,  85  ((6)): (601-606).  [PMID:20953585]
15. Bart R B Haverkorn van Rijsewijk,Annik Nanchen,Sophie Nallet,Roelco J Kleijn,Uwe Sauer.  (2011-04-01)  Large-scale 13C-flux analysis reveals distinct transcriptional control of respiratory and fermentative metabolism in Escherichia coli..  Molecular systems biology,  7  (477-477).  [PMID:21451587]
16. Caroline Raeppel,Marie Nief,Marie Fabritius,Lucie Racault,Brice M Appenzeller,Maurice Millet.  (2011-10-04)  Simultaneous analysis of pesticides from different chemical classes by using a derivatisation step and gas chromatography-mass spectrometry..  Journal of chromatography. A,  1218  ((44)): (8123-8129).  [PMID:21962330]
17. David Saraiva,Rute Semedo,Maria da Conceição Castilho,José Manuel Silva,Fernando Ramos.  (2011-11-18)  Selection of the derivatization reagent--the case of human blood cholesterol, its precursors and phytosterols GC-MS analyses..  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,  879  ((32)): (3806-3811).  [PMID:22088355]
18. Yong Yu,Laosheng Wu.  (2012-01-31)  Analysis of endocrine disrupting compounds, pharmaceuticals and personal care products in sewage sludge by gas chromatography-mass spectrometry..  Talanta,  89  (258-263).  [PMID:22284489]
19. Xiaowei Wang,Li Lin,Tiangang Luan,Lihua Yang,Nora F Y Tam.  (2012-10-31)  Determination of hydroxylated metabolites of polycyclic aromatic hydrocarbons in sediment samples by combining subcritical water extraction and dispersive liquid-liquid microextraction with derivatization..  Analytica chimica acta,  753  (57-63).  [PMID:23107137]
20. Tsubasa Nakajima,Shuichi Kajihata,Katsunori Yoshikawa,Fumio Matsuda,Chikara Furusawa,Takashi Hirasawa,Hiroshi Shimizu.  (2014-06-28)  Integrated metabolic flux and omics analysis of Synechocystis sp. PCC 6803 under mixotrophic and photoheterotrophic conditions..  Plant & cell physiology,  55  ((9)): (1605-1612).  [PMID:24969233]
21. Valentina Manzo,Luis Honda,Orielle Navarro,Loreto Ascar,Pablo Richter.  (2014-07-26)  Microextraction of non-steroidal anti-inflammatory drugs from waste water samples by rotating-disk sorptive extraction..  Talanta,  128  (486-492).  [PMID:25059190]
22. Whitney D Hollinshead,Arul M Varman,Le You,Zachary Hembree,Yinjie J Tang.  (2014-08-02)  Boosting D-lactate production in engineered cyanobacteria using sterilized anaerobic digestion effluents..  Bioresource technology,  169  (462-467).  [PMID:25084044]
23. Yalun Arifin,Colin Archer,SooA Lim,Lake-Ee Quek,Haryadi Sugiarto,Esteban Marcellin,Claudia E Vickers,Jens O Krömer,Lars K Nielsen.  (2014-08-16)  Escherichia coli W shows fast, highly oxidative sucrose metabolism and low acetate formation..  Applied microbiology and biotechnology,  98  ((21)): (9033-9044).  [PMID:25125039]
24. A Iparraguirre,R Rodil,J B Quintana,E Bizkarguenaga,A Prieto,O Zuloaga,R Cela,L A Fernández.  (2014-08-19)  Matrix solid-phase dispersion of polybrominated diphenyl ethers and their hydroxylated and methoxylated analogues in lettuce, carrot and soil..  Journal of chromatography. A,  1360  (57-65).  [PMID:25130091]
25. Panagiota Nikolaou,Ioannis Papoutsis,Artemisia Dona,Chara Spiliopoulou,Sotiris Athanaselis.  (2014-09-23)  Development and validation of a GC/MS method for the simultaneous determination of levetiracetam and lamotrigine in whole blood..  Journal of pharmaceutical and biomedical analysis,  102  (25-32).  [PMID:25238568]
26. Gabriel B Akanni,James C du Preez,Laurinda Steyn,Stephanus G Kilian.  (2014-11-06)  Protein enrichment of an Opuntia ficus-indica cladode hydrolysate by cultivation of Candida utilis and Kluyveromyces marxianus..  Journal of the science of food and agriculture,  95  ((5)): (1094-1102).  [PMID:25371280]
27. Grethe M Olsen,Ursula Sonnewald.  (2014-12-03)  Glutamate: Where does it come from and where does it go?.  Neurochemistry international,  88  (47-52).  [PMID:25447768]
28. Martin Ferus,David Nesvorný,Jiří Šponer,Petr Kubelík,Regina Michalčíková,Violetta Shestivská,Judit E Šponer,Svatopluk Civiš.  (2014-12-10)  High-energy chemistry of formamide: a unified mechanism of nucleobase formation..  Proceedings of the National Academy of Sciences of the United States of America,  112  ((3)): (657-662).  [PMID:25489115]
29. Toshiaki Yoshida.  (2015-01-15)  4-Methoxymethyl-2,3,5,6-tetrafluorobenzyl alcohol as a urinary biomarker for monitoring of metofluthrin, a fluorine-containing pyrethroid, in exposed rats..  Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals,  20  ((1)): (71-76).  [PMID:25585926]
30. .  ()  Fabric phase sorptive extraction: a new sorptive microextraction technique for the determination of non-steroidal anti-inflammatory drugs from environmental water samples..  Analytica chimica acta,  865  (22-).  [PMID:25732581]
31. Fatemeh Tohidi,Zongwei Cai.  (2015-03-27)  GC/MS analysis of triclosan and its degradation by-products in wastewater and sludge samples from different treatments..  Environmental science and pollution research international,  22  ((15)): (11387-11400).  [PMID:25810102]
32. Anna Topolewska,Karolina Czarnowska,Łukasz P Haliński,Piotr Stepnowski.  (2015-04-16)  Evaluation of four derivatization methods for the analysis of fatty acids from green leafy vegetables by gas chromatography..  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,  990  (150-157).  [PMID:25875587]
33. Kenshi Hayakawa,Shuichi Kajihata,Fumio Matsuda,Hiroshi Shimizu.  (2015-04-29)  (13)C-metabolic flux analysis in S-adenosyl-L-methionine production by Saccharomyces cerevisiae..  Journal of bioscience and bioengineering,  120  ((5)): (532-538).  [PMID:25912448]
34. Yeng F Her,Molly Nelson-Holte,Louis James Maher.  (2015-05-20)  Oxygen concentration controls epigenetic effects in models of familial paraganglioma..  PloS one,  10  ((5)): (e0127471-e0127471).  [PMID:25985299]
35. Priyadarshini Pantham,Fredrick J Rosario,Mark Nijland,Alex Cheung,Peter W Nathanielsz,Theresa L Powell,Henry L Galan,Cun Li,Thomas Jansson.  (2015-08-08)  Reduced placental amino acid transport in response to maternal nutrient restriction in the baboon..  American journal of physiology. Regulatory, integrative and comparative physiology,  309  ((7)): (R740-R746).  [PMID:26246504]
36. Valentina Manzo,Karla Ulisse,Inés Rodríguez,Eduardo Pereira,Pablo Richter.  (2015-09-08)  A molecularly imprinted polymer as the sorptive phase immobilized in a rotating disk extraction device for the determination of diclofenac and mefenamic acid in wastewater..  Analytica chimica acta,  889  (130-137).  [PMID:26343435]
37. Coriness Piñeyro-Ruiz,Nataliya E Chorna,Marcos Raymond Pérez-Brayfield,Juan Carlos Jorge.  (2020-05-12)  Severity-Dependent Profile of the Metabolome in Hypospadias..  Frontiers in pediatrics,  8  (202-202).  [PMID:32391298]
38. Allison N Lau,Zhaoqi Li,Laura V Danai,Anna M Westermark,Alicia M Darnell,Raphael Ferreira,Vasilena Gocheva,Sharanya Sivanand,Evan C Lien,Kiera M Sapp,Jared R Mayers,Giulia Biffi,Christopher R Chin,Shawn M Davidson,David A Tuveson,Tyler Jacks,Nicholas J Matheson,Omer Yilmaz,Matthew G Vander Heiden.  (2020-07-11)  Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma..  eLife,  9    [PMID:32648540]
39. Stephane Morville,Anne Scheyer,Philippe Mirabel,Maurice Millet.  (2004-11-30)  A multiresidue method for the analysis of phenols and nitrophenols in the atmosphere..  Journal of environmental monitoring : JEM,  6  ((12)): (963-966).  [PMID:15568044]
40. P Canosa,I Rodriguez,E Rubí,R Cela.  (2005-05-11)  Optimization of solid-phase microextraction conditions for the determination of triclosan and possible related compounds in water samples..  Journal of chromatography. A,  1072  ((1)): (107-115).  [PMID:15881465]
41. Isaac Ohsawa,Yasuo Seto.  (2006-05-19)  Determination of nitrogen mustard hydrolysis products, ethanolamines by gas chromatography-mass spectrometry after tert-butyldimethylsilyl derivatization..  Journal of chromatography. A,  1122  ((1-2)): (242-248).  [PMID:16707130]
42. Bill Guthery,Alan Bassindale,Colin T Pillinger,Geraint H Morgan.  (2009-01-07)  The detection of various opiates and benzodiazepines by comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry..  Rapid communications in mass spectrometry : RCM,  23  ((3)): (340-348).  [PMID:19125414]
43. Ho-Sang Shin,Hyun-Hee Lim.  (2011-02-01)  Simultaneous determination of 2-naphthol and 1-hydroxy pyrene in urine by gas chromatography-mass spectrometry..  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,  879  ((7-8)): (489-494).  [PMID:21277841]
44. François Leclerc,Marie-France Dubois,Aziz Aris.  (2014-04-15)  Maternal, placental and fetal exposure to bisphenol A in women with and without preeclampsia..  Hypertension in pregnancy,  33  ((3)): (341-348).  [PMID:24724919]
45. Xue Shi,Xiaoli Wei,Xinmin Yin,Yuhua Wang,Min Zhang,Cuiqing Zhao,Haiyang Zhao,Craig J McClain,Wenke Feng,Xiang Zhang.  (2015-01-17)  Hepatic and fecal metabolomic analysis of the effects of Lactobacillus rhamnosus GG on alcoholic fatty liver disease in mice..  Journal of proteome research,  14  ((2)): (1174-1182).  [PMID:25592873]
46. Shuichi Kajihata,Fumio Matsuda,Mika Yoshimi,Kenshi Hayakawa,Chikara Furusawa,Akihisa Kanda,Hiroshi Shimizu.  (2015-01-31)  ¹³C-based metabolic flux analysis of Saccharomyces cerevisiae with a reduced Crabtree effect..  Journal of bioscience and bioengineering,  120  ((2)): (140-144).  [PMID:25634548]
47. Jong-Kuk Na,Jae-Kwang Kim,Dool-Yi Kim,Sarah M Assmann.  (2015-05-07)  Expression of potato RNA-binding proteins StUBA2a/b and StUBA2c induces hypersensitive-like cell death and early leaf senescence in Arabidopsis..  Journal of experimental botany,  66  ((13)): (4023-4033).  [PMID:25944928]
48. U Agarwal,Q Hu,R L Baldwin,B J Bequette.  (2015-05-29)  Role of rumen butyrate in regulation of nitrogen utilization and urea nitrogen kinetics in growing sheep..  Journal of animal science,  93  ((5)): (2382-2390).  [PMID:26020334]
49. T Schettgen,A Alt,P Dewes,T Kraus.  (2015-06-06)  Simple and sensitive GC/MS-method for the quantification of urinary phenol, o- and m-cresol and ethylphenols as biomarkers of exposure to industrial solvents..  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,  995-996  (93-100).  [PMID:26046979]
50. Nicolas Morin,Hans Peter H Arp,Sarah E Hale.  (2015-06-10)  Bisphenol A in Solid Waste Materials, Leachate Water, and Air Particles from Norwegian Waste-Handling Facilities: Presence and Partitioning Behavior..  Environmental science & technology,  49  ((13)): (7675-7683).  [PMID:26055751]
51. Can Xie, Wei Ni, Fei Liu, Gangtian Zhu, Yuguang Hou.  (2023)  Analysis, distribution and evolution of individual carboxylic acids in crude oil during biodegradation.  ORGANIC GEOCHEMISTRY,  178  (104573).  [PMID:]
52. Wei Ni, Gangtian Zhu, Fei Liu, Can Xie, Wei Li, Shukui Zhu.  (2022)  Rapid profiling of carboxylic acids in reservoir biodegraded crude oils using gas purge microsyringe extraction coupled to comprehensive two-dimensional gas chromatography-mass spectrometry.  FUEL,  316  (123312).  [PMID:]

Solution Calculators

Privacy Policy Website Terms of Use Return policy Terms and Conditions of Sale Cookie Policy Sales Policy
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
Copyright © 2023-present Aladdin Scientific Corp . All rights reserved.