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NADPH - ≥93%, high purity , CAS No.2646-71-1

19 Citations
  • ≥93%
Item Number
N276326
Grouped product items
SKUSizeAvailabilityPrice Qty
N276326-50mg
50mg
In stock
$48.90
N276326-100mg
100mg
In stock
$79.90
N276326-250mg
250mg
In stock
$159.90
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Coenzyme.

Basic Description

Synonyms2646-71-1 | Nadph tetrasodium salt | EINECS 220-163-3 | NADPH tetrasodium | Dihydronicotinamide-adenine dinucleotide phosphate, tetrasodium salt | MFCD00036263 | | A-NADPH | NADPH (sodium salt) | beta-Nicotinamide adenine dinucleotide 2'-phosphate reduced tetrasodium salt
Specifications & Purity≥93%
Biochemical and Physiological MechanismsUbiquitous coenzyme and biological reducing agent that acts as an electron donor for many redox enzymes including nitric oxide synthetase. Generated by reduction of the electron acceptor NADP+.
Storage TempProtected from light,Store at -20°C,Desiccated
Shipped InIce chest + Ice pads
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.

Names and Identifiers

Pubchem Sid488201525
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488201525
IUPAC Name tetrasodium;[(2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-[[[[(2R,3S,4R,5R)-5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl]oxymethyl]-4-hydroxyoxolan-3-yl] phosphate
INCHI InChI=1S/C21H30N7O17P3.4Na/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32;;;;/h1,3-4,7-8,10-11,13-16,20-21,29-31H,2,5-6H2,(H2,23,32)(H,36,37)(H,38,39)(H2,22,24,25)(H2,33,34,35);;;;/q;4*+1/p-4/t10-,11-,13-,14-,15-,16-,20-,21-;;;;/m1..../s1
InChi Key WYWWVJHQDVCHKF-ITGWJZMWSA-J
Canonical SMILES C1C=CN(C=C1C(=O)N)C2C(C(C(O2)COP(=O)([O-])OP(=O)([O-])OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)OP(=O)([O-])[O-])O)O)O.[Na+].[Na+].[Na+].[Na+]
Isomeric SMILES C1C=CN(C=C1C(=O)N)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)([O-])OP(=O)([O-])OC[C@@H]3[C@H]([C@H]([C@@H](O3)N4C=NC5=C(N=CN=C54)N)OP(=O)([O-])[O-])O)O)O.[Na+].[Na+].[Na+].[Na+]
PubChem CID 52945042
Molecular Weight 833.35 (anhydrous basis)

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

28 results found

Lot NumberCertificate TypeDateItem
G2423030Certificate of AnalysisJul 30, 2024 N276326
G2419065Certificate of AnalysisJul 29, 2024 N276326
G2419064Certificate of AnalysisJul 29, 2024 N276326
G2403036Certificate of AnalysisJun 18, 2024 N276326
F2413087Certificate of AnalysisJun 18, 2024 N276326
F2404216Certificate of AnalysisJun 05, 2024 N276326
F2404215Certificate of AnalysisJun 05, 2024 N276326
F2404214Certificate of AnalysisJun 05, 2024 N276326
D2415020Certificate of AnalysisApr 19, 2024 N276326
D2415019Certificate of AnalysisApr 19, 2024 N276326
A2305301Certificate of AnalysisMar 07, 2024 N276326
D2327022Certificate of AnalysisJan 31, 2024 N276326
L2306104Certificate of AnalysisDec 08, 2023 N276326
K2309008Certificate of AnalysisNov 14, 2023 N276326
J2316011Certificate of AnalysisOct 25, 2023 N276326
H2331025Certificate of AnalysisSep 08, 2023 N276326
H2331024Certificate of AnalysisSep 07, 2023 N276326
D2327019Certificate of AnalysisMay 02, 2023 N276326
D2327018Certificate of AnalysisMay 02, 2023 N276326
D2327021Certificate of AnalysisApr 29, 2023 N276326
D2327020Certificate of AnalysisApr 29, 2023 N276326
A2305299Certificate of AnalysisJan 12, 2023 N276326
A2305351Certificate of AnalysisJan 12, 2023 N276326
A2305352Certificate of AnalysisJan 12, 2023 N276326
J2220037Certificate of AnalysisNov 03, 2022 N276326
J2220038Certificate of AnalysisNov 03, 2022 N276326
C2212542Certificate of AnalysisJun 01, 2022 N276326
C2212546Certificate of AnalysisJun 01, 2022 N276326

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Chemical and Physical Properties

Solubility10 mM NaOH: soluble 50 mg/mL, clear
Sensitivitylight sensitive;Heat sensitive

Safety and Hazards(GHS)

Merck Index 6348

Related Documents

 SDS

 Specification Sheet

FAQs and Articles

FAQ
Alcohol dehydrogenase (ADH)
Categories: Technical articles
Tags:
Enzyme Reducing agent NAD NADH NADPH ADH

Citations of This Product

1. Ni-hong Pang, Ren-ai Xu, Lian-guo Chen, Zhe Chen, Guo-xin Hu, Bo-wen Zhang.  (2024)  Inhibitory effects of the main metabolites of Apatinib on CYP450 isozymes in human and rat liver microsomes.  TOXICOLOGY IN VITRO,  95  (105739).  [PMID:38042355]
2. Zhongzhong Lu, Jincong Yan, Guangyue Zu, Mingsheng Xu, Jihuan Liu, Ye Zhang, Lei Shi, Xifeng Fei, Yi Cao, Renjun Pei.  (2023)  Hypoxia-Responsive T2-to-T1 Dynamically Switchable Extremely Small Iron Oxide Nanoparticles for Sensitive Tumor Imaging In Vivo.  BIOCONJUGATE CHEMISTRY,  34  (9): (1622–1632).  [PMID:37584604]
3. Pengyi Chen, Chengguo Pang, Tianen Xu, Peiliang Dong, Hua Han.  (2023)  Characterization of chemical constituents and metabolites in vivo and in vitro after oral administration of Wuteng tablets in rats by UHPLC–Q/TOF–MS.  BIOMEDICAL CHROMATOGRAPHY,  37  (10): (e5704).  [PMID:37496363]
4. Liu Lang, Wang Suji, Zuo Junfeng, Zhang Xiaohe, Peng Xiong, Wang Kang, Chen Maohua.  (2023)  Characterization and fitness cost of bifenthrin resistance in Rhopalosiphum padi (Hemiptera: Aphididae).  JOURNAL OF ECONOMIC ENTOMOLOGY,      [PMID:37478406]
5. Jia Huang, Guiming Deng, Shuya Wang, Tianjiao Zhao, Qiaohui Chen, Yuqi Yang, Yongqi Yang, Jinping Zhang, Yayun Nan, Zhaoqian Liu, Ke Cao, Qiong Huang, Kelong Ai.  (2023)  A NIR-II Photoactivatable “ROS Bomb” with High-Density Cu2O-Supported MoS2 Nanoflowers for Anticancer Therapy.  Advanced Science,    (2302208).  [PMID:37340606]
6. Kai Wang, Wentao Zhou, Xiangyu Jin, Xuwei Shang, Xiaomei Wu, Lijuan Wen, Sufen Li, Yiling Hong, Jia Ke, Yichong Xu, Hong Yuan, Fuqiang Hu.  (2023)  Enhanced brain delivery of hypoxia-sensitive liposomes by hydroxyurea for rescue therapy of hyperacute ischemic stroke.  Nanoscale,  15  (27): (11625-11646).  [PMID:37377137]
7. Dingyue Zhang, Lixia Dong, Wenyong Yang, Kui Wang, Dingyue Zhang, Lixia Dong, Wenyong Yang, Kui Wang.  (2023)  Identification of NQO1 as a target of herbal drug agrimol B in hepatocellular carcinoma.  AUSTRALIAN JOURNAL OF CHEMISTRY,  76  (8): (465-475).  [PMID:]
8. Shuanghu Wang, Mengming Xia, Yu Wang, Zebei Lu, Peiwu Geng, Dapeng Dai, Yunfang Zhou, Qingjun Wu.  (2023)  Inhibitory effect of Schisandrin on the pharmacokinetics of poziotinib in vivo and in vitro by UPLC-MS/MS.  Thoracic Cancer,  14  (14): (1276-1285).  [PMID:36973912]
9. Min-Yu Wang, Shun-Ju Cai, Jia-Chun Lin, Xiao-Jun Ji, Zhi-Gang Zhang.  (2023)  New Anti-Prelog Stereospecific Whole-Cell Biocatalyst for Asymmetric Reduction of Prochiral Ketones.  MOLECULES,  28  (3): (1422).  [PMID:36771091]
10. Fangying Yu, Xuwei Shang, Zixu Wang, Yun Zhu, Simin Chen, Hong Yuan, Fuqiang Hu.  (2023)  Drug-independent NADPH-consuming micelles collaborate with ROS-generator for cascade ferroptosis amplification by impairing redox homeostasis.  Materials Today Bio,  18  (100532).  [PMID:36691607]
11. Bin Huang, Kai Yang, Charles Amanze, Zhen Yan, Hongbo Zhou, Xueduan Liu, Guanzhou Qiu, Weimin Zeng.  (2023)  Sequence and structure-guided discovery of a novel NADH-dependent 7β-hydroxysteroid dehydrogenase for efficient biosynthesis of ursodeoxycholic acid.  BIOORGANIC CHEMISTRY,  131  (106340).  [PMID:36586301]
12. Shujing Xu, Lin Sun, Dang Ding, Xujie Zhang, Xinyong Liu, Peng Zhan.  (2022)  Metabolite Identification of HIV-1 Capsid Modulators PF74 and 11L in Human Liver Microsomes.  Metabolites,  12  (8): (752).  [PMID:36005624]
13. Yaxuan Qian, Zhuoran Jiang, Yan Long, Houguo Fei, Heng Song, Cunlan Guo.  (2022)  Electroenzymatic Aromatic Nitration via an Electric Field and Electro-Mediator.  ACS Sustainable Chemistry & Engineering,  10  (20): (6667–6674).  [PMID:]
14. Yixiang Li, Yajun Bai, Tai-Ping Fan, Xiaohui Zheng, Yujie Cai.  (2021)  Characterization of a putative tropinone reductase from Tarenaya hassleriana with a broad substrate specificity.  BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY,  69  (6): (2530-2539).  [PMID:34902878]
15. Xueqing Yang, Xinru Li, Xinzhu Cang, Jianglong Guo, Xiujing Shen, Kongming Wu.  (2021)  Influence of seasonal migration on the development of the insecticide resistance of oriental armyworm (Mythimna separata) to λ-cyhalothrin.  PEST MANAGEMENT SCIENCE,  78  (3): (1194-1205).  [PMID:34825453]
16. Jiawei Guo, Fengwei Li, Fangyuan Cheng, Li Ma, Xiaohui Liu, Pradeepraj Durairaj, Gang Zhang, Dandan Tang, Xiangtian Long, Wei Zhang, Lei Du, Xingwang Zhang, Shengying Li.  (2021)  Bacterial Biosynthetic P450 Enzyme PikCD50N: A Potential Biocatalyst for the Preparation of Human Drug Metabolites.  JOURNAL OF ORGANIC CHEMISTRY,  86  (21): (14563–14571).  [PMID:34662127]
17. Rui Cai,Yahong Yuan,Zhouli Wang,Chunfeng Guo,Bin Liu,Laping Liu,Yutang Wang,Tianli Yue.  (2015-08-05)  Precursors and metabolic pathway for guaiacol production by Alicyclobacillus acidoterrestris..  International journal of food microbiology,  214  (48-53).  [PMID:26241489]
18. Kunpeng Li,Rongzhen Zhang,Yan Xu,Zhimeng Wu,Jing Li,Xiaotian Zhou,Jiawei Jiang,Haiyan Liu,Rong Xiao.  (2017-06-10)  Sortase A-mediated crosslinked short-chain dehydrogenases/reductases as novel biocatalysts with improved thermostability and catalytic efficiency..  Scientific reports,  7  ((1)): (3081-3081).  [PMID:28596548]
19. Zhou, et al..  (2021)  Hydrolase CehA and a Novel Two-Component 1-Naphthol Hydroxylase CehC1C2 are Responsible for the Two Initial Steps of Carbaryl Degradation in Rhizobium sp. X9..  Journal of Agricultural and Food Chemistry,  68  (14739-14747).  [PMID:33264024]

References

1. Gong FX et al..  (2021)  De-dimerization of PTB is catalyzed by PDI and is involved in the regulation of p53 translation..  Nucleic Acids Res,  49  (16): (9342-9352).  [PMID:34403458]
2. Ni-hong Pang, Ren-ai Xu, Lian-guo Chen, Zhe Chen, Guo-xin Hu, Bo-wen Zhang.  (2024)  Inhibitory effects of the main metabolites of Apatinib on CYP450 isozymes in human and rat liver microsomes.  TOXICOLOGY IN VITRO,  95  (105739).  [PMID:38042355]
3. Zhongzhong Lu, Jincong Yan, Guangyue Zu, Mingsheng Xu, Jihuan Liu, Ye Zhang, Lei Shi, Xifeng Fei, Yi Cao, Renjun Pei.  (2023)  Hypoxia-Responsive T2-to-T1 Dynamically Switchable Extremely Small Iron Oxide Nanoparticles for Sensitive Tumor Imaging In Vivo.  BIOCONJUGATE CHEMISTRY,  34  (9): (1622–1632).  [PMID:37584604]
4. Pengyi Chen, Chengguo Pang, Tianen Xu, Peiliang Dong, Hua Han.  (2023)  Characterization of chemical constituents and metabolites in vivo and in vitro after oral administration of Wuteng tablets in rats by UHPLC–Q/TOF–MS.  BIOMEDICAL CHROMATOGRAPHY,  37  (10): (e5704).  [PMID:37496363]
5. Liu Lang, Wang Suji, Zuo Junfeng, Zhang Xiaohe, Peng Xiong, Wang Kang, Chen Maohua.  (2023)  Characterization and fitness cost of bifenthrin resistance in Rhopalosiphum padi (Hemiptera: Aphididae).  JOURNAL OF ECONOMIC ENTOMOLOGY,      [PMID:37478406]
6. Jia Huang, Guiming Deng, Shuya Wang, Tianjiao Zhao, Qiaohui Chen, Yuqi Yang, Yongqi Yang, Jinping Zhang, Yayun Nan, Zhaoqian Liu, Ke Cao, Qiong Huang, Kelong Ai.  (2023)  A NIR-II Photoactivatable “ROS Bomb” with High-Density Cu2O-Supported MoS2 Nanoflowers for Anticancer Therapy.  Advanced Science,    (2302208).  [PMID:37340606]
7. Kai Wang, Wentao Zhou, Xiangyu Jin, Xuwei Shang, Xiaomei Wu, Lijuan Wen, Sufen Li, Yiling Hong, Jia Ke, Yichong Xu, Hong Yuan, Fuqiang Hu.  (2023)  Enhanced brain delivery of hypoxia-sensitive liposomes by hydroxyurea for rescue therapy of hyperacute ischemic stroke.  Nanoscale,  15  (27): (11625-11646).  [PMID:37377137]
8. Dingyue Zhang, Lixia Dong, Wenyong Yang, Kui Wang, Dingyue Zhang, Lixia Dong, Wenyong Yang, Kui Wang.  (2023)  Identification of NQO1 as a target of herbal drug agrimol B in hepatocellular carcinoma.  AUSTRALIAN JOURNAL OF CHEMISTRY,  76  (8): (465-475).  [PMID:]
9. Shuanghu Wang, Mengming Xia, Yu Wang, Zebei Lu, Peiwu Geng, Dapeng Dai, Yunfang Zhou, Qingjun Wu.  (2023)  Inhibitory effect of Schisandrin on the pharmacokinetics of poziotinib in vivo and in vitro by UPLC-MS/MS.  Thoracic Cancer,  14  (14): (1276-1285).  [PMID:36973912]
10. Min-Yu Wang, Shun-Ju Cai, Jia-Chun Lin, Xiao-Jun Ji, Zhi-Gang Zhang.  (2023)  New Anti-Prelog Stereospecific Whole-Cell Biocatalyst for Asymmetric Reduction of Prochiral Ketones.  MOLECULES,  28  (3): (1422).  [PMID:36771091]
11. Fangying Yu, Xuwei Shang, Zixu Wang, Yun Zhu, Simin Chen, Hong Yuan, Fuqiang Hu.  (2023)  Drug-independent NADPH-consuming micelles collaborate with ROS-generator for cascade ferroptosis amplification by impairing redox homeostasis.  Materials Today Bio,  18  (100532).  [PMID:36691607]
12. Bin Huang, Kai Yang, Charles Amanze, Zhen Yan, Hongbo Zhou, Xueduan Liu, Guanzhou Qiu, Weimin Zeng.  (2023)  Sequence and structure-guided discovery of a novel NADH-dependent 7β-hydroxysteroid dehydrogenase for efficient biosynthesis of ursodeoxycholic acid.  BIOORGANIC CHEMISTRY,  131  (106340).  [PMID:36586301]
13. Shujing Xu, Lin Sun, Dang Ding, Xujie Zhang, Xinyong Liu, Peng Zhan.  (2022)  Metabolite Identification of HIV-1 Capsid Modulators PF74 and 11L in Human Liver Microsomes.  Metabolites,  12  (8): (752).  [PMID:36005624]
14. Yaxuan Qian, Zhuoran Jiang, Yan Long, Houguo Fei, Heng Song, Cunlan Guo.  (2022)  Electroenzymatic Aromatic Nitration via an Electric Field and Electro-Mediator.  ACS Sustainable Chemistry & Engineering,  10  (20): (6667–6674).  [PMID:]
15. Yixiang Li, Yajun Bai, Tai-Ping Fan, Xiaohui Zheng, Yujie Cai.  (2021)  Characterization of a putative tropinone reductase from Tarenaya hassleriana with a broad substrate specificity.  BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY,  69  (6): (2530-2539).  [PMID:34902878]
16. Xueqing Yang, Xinru Li, Xinzhu Cang, Jianglong Guo, Xiujing Shen, Kongming Wu.  (2021)  Influence of seasonal migration on the development of the insecticide resistance of oriental armyworm (Mythimna separata) to λ-cyhalothrin.  PEST MANAGEMENT SCIENCE,  78  (3): (1194-1205).  [PMID:34825453]
17. Jiawei Guo, Fengwei Li, Fangyuan Cheng, Li Ma, Xiaohui Liu, Pradeepraj Durairaj, Gang Zhang, Dandan Tang, Xiangtian Long, Wei Zhang, Lei Du, Xingwang Zhang, Shengying Li.  (2021)  Bacterial Biosynthetic P450 Enzyme PikCD50N: A Potential Biocatalyst for the Preparation of Human Drug Metabolites.  JOURNAL OF ORGANIC CHEMISTRY,  86  (21): (14563–14571).  [PMID:34662127]
18. Rui Cai,Yahong Yuan,Zhouli Wang,Chunfeng Guo,Bin Liu,Laping Liu,Yutang Wang,Tianli Yue.  (2015-08-05)  Precursors and metabolic pathway for guaiacol production by Alicyclobacillus acidoterrestris..  International journal of food microbiology,  214  (48-53).  [PMID:26241489]
19. Kunpeng Li,Rongzhen Zhang,Yan Xu,Zhimeng Wu,Jing Li,Xiaotian Zhou,Jiawei Jiang,Haiyan Liu,Rong Xiao.  (2017-06-10)  Sortase A-mediated crosslinked short-chain dehydrogenases/reductases as novel biocatalysts with improved thermostability and catalytic efficiency..  Scientific reports,  7  ((1)): (3081-3081).  [PMID:28596548]
20. Zhou, et al..  (2021)  Hydrolase CehA and a Novel Two-Component 1-Naphthol Hydroxylase CehC1C2 are Responsible for the Two Initial Steps of Carbaryl Degradation in Rhizobium sp. X9..  Journal of Agricultural and Food Chemistry,  68  (14739-14747).  [PMID:33264024]

Solution Calculators

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