nafamostat , CAS No.81525-10-2, Channel blocker of ASIC1;Channel blocker of ASIC2;Channel blocker of ASIC3;Inhibitor of complement C1r;Inhibitor of serine protease 1;Inhibitor of transmembrane serine protease 2;Channel blocker of TRPM7;Inhibitor of tryptase alpha/beta 1

Item Number

N612138

Grouped product items
SKU	Size	Availability	Price	Qty
N612138-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$922.90
N612138-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$3,700.90

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Basic Description

Synonyms	Nafamostat\|81525-10-2\|Nafamostat [INN]\|Nafamstat\|(6-carbamimidoylnaphthalen-2-yl) 4-(diaminomethylideneamino)benzoate\|CHEMBL273264\|Y25LQ0H97D\|p-Guanidinobenzoic acid ester with 6-hydroxy-2-naphthamidine\|Nafamostat (INN)\|Benzoic acid, 4-((aminoiminomethyl)
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	CHANNEL BLOCKER, INHIBITOR
Mechanism of action	Channel blocker of ASIC1;Channel blocker of ASIC2;Channel blocker of ASIC3;Inhibitor of complement C1r;Inhibitor of serine protease 1;Inhibitor of transmembrane serine protease 2;Channel blocker of TRPM7;Inhibitor of tryptase alpha/beta 1

Names and Identifiers

IUPAC Name	(6-carbamimidoylnaphthalen-2-yl) 4-(diaminomethylideneamino)benzoate
INCHI	InChI=1S/C19H17N5O2/c20-17(21)14-2-1-13-10-16(8-5-12(13)9-14)26-18(25)11-3-6-15(7-4-11)24-19(22)23/h1-10H,(H3,20,21)(H4,22,23,24)
InChi Key	MQQNFDZXWVTQEH-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=CC=C1C(=O)OC2=CC3=C(C=C2)C=C(C=C3)C(=N)N)N=C(N)N
Isomeric SMILES	C1=CC(=CC=C1C(=O)OC2=CC3=C(C=C2)C=C(C=C3)C(=N)N)N=C(N)N
Alternate CAS	81525-10-2
PubChem CID	4413
MeSH Entry Terms	6'-amidino-2-naphthyl 4-guanidinobenzoate;6'-amidino-2-naphthyl 4-guanidinobenzoate, dimethanesulfonate;Benzoic acid, 4-((aminoiminomethyl)amino)-, 6-(aminoiminomethyl)-2-naphthalenyl ester;Benzoic acid, 4-((aminoiminomethyl)amino)-, 6-(aminoiminomethyl)-
Molecular Weight	347.4

PubChem CID

CAS Registry No.

ChEMBL Ligand

Wikipedia

Reactome Reaction

Reactome Drug

DrugCentral Ligand

RCSB PDB Ligand

References

1. Yamamoto M, Matsuyama S, Li X, Takeda M, Kawaguchi Y, Inoue JI, Matsuda Z. (2016) Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay.. Antimicrob Agents Chemother, 60 (11): (6532-6539). [PMID:27550352]
2. Hoffmann M, Schroeder S, Kleine-Weber H, Müller MA, Drosten C, Pöhlmann S. (2020) Nafamostat Mesylate Blocks Activation of SARS-CoV-2: New Treatment Option for COVID-19.. Antimicrob Agents Chemother, 64 (6): (589-97). [PMID:32312781]

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Basic Description