NAMI-A - ≥98.0%, high purity , CAS No.201653-76-1

Item Number

N646402

Grouped product items
SKU	Size	Availability	Price
N646402-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$168.90
N646402-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$420.90
N646402-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$600.90
N646402-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,800.90
N646402-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,520.90

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Basic Description

Synonyms	NAMI-A\|201653-76-1\|60487Z56XW\|UNII-60487Z56XW\|Imidazolium-trans-tetrachloro(dimethylsulfoxide)imidazoleruthenium(III)\|1H-imidazole;1H-imidazol-3-ium;methylsulfinylmethane;ruthenium(3+);tetrachloride\|1H-Imidazole (OC-6-11)-tetrachloro(1H-imidazole-kappaN3)
Specifications & Purity	≥98.0%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	NAMI-A is a ruthenium-based drug characterised by the selective activity against tumour metastases, inhibits the adhesion and migration.In vitro: NAMI-A can significantly affect tumor cells with metastatic ability.The half lifetime of NAMI-A elimination from the lungs is longer than for liver, kidney, and primary tumor. NAMI-A bound to collagen is active on tumor cells as shown in vitro by an invasion test, using a modified Boyden chamber and Matrigel, and it inhibits the matrix metallo-proteinases MMP-2 and MMP-9 at micromolar concentrations.The ruthenium drug NAMI-A inhibits the adhesion and migration of colorectal cancer cells. NAMI-A decreases α5β1 integrin expression and FAK auto-phosphorylation on Tyr 397.In vivo: The reference for NAMI-A is 35 mg/kg/day. Form:Solid

Names and Identifiers

IUPAC Name	1H-imidazole;1H-imidazol-3-ium;methylsulfinylmethane;ruthenium(3+);tetrachloride
INCHI	InChI=1S/2C3H4N2.C2H6OS.4ClH.Ru/c21-2-5-3-4-1;1-4(2)3;;;;;/h21-3H,(H,4,5);1-2H3;4*1H;/q;;;;;;;+3/p-3
InChi Key	RJZBTXZRLXLLKO-UHFFFAOYSA-K
Canonical SMILES	CS(=O)C.C1=C[NH+]=CN1.C1=CN=CN1.[Cl-].[Cl-].[Cl-].[Cl-].[Ru+3]
Isomeric SMILES	CS(=O)C.C1=C[NH+]=CN1.C1=CN=CN1.[Cl-].[Cl-].[Cl-].[Cl-].[Ru+3]
PubChem CID	133082692
Molecular Weight	458.18

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Basic Description