| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| N655466-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $478.90 |
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | Namitecan is a potent topoisomerase I inhibitor, with antitumor property. In Vitro Namitecan and cetuximab cooperate in inhibiting EGFR expression. Namitecan induces a dose-dependent decrease in EGFR expression in the different cell lines. ST1968 induces a comparable level of apoptosis in A431 and A431/TPT cells with IC 50 of 0.21 and 0.29 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Namitecan (10 mg/kg) in combination with cetuximab (1 mg/mouse) induces synergistic antitumor effects in SCC models as a function of EGFR gene copy number . ST1968 (25 mg/kg) causes acceptable body weight loss and no toxic deaths. ST1968 produces a 100% complete response rate in the mice bearing the A431 tumor, and retains a relevant activity in the topotecan-resistant tumor. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:Topoisomerase I |
| Canonical SMILES | CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C5=CC=CC=C5N=C4C3=C2)C=NOCCN)O |
|---|---|
| Molecular Weight | 434.44 |
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