| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| N407879-1ml | 1ml | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $283.90 |
STAT3 Selective Inhibitors | Activators
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Storage Temp | Store at -80°C |
| Shipped In | Dry ice |
| Grade | Moligand™ |
| Product Description | Information Napabucasin (BBI608) is an orally availableStat3and cancer cell stemness inhibitor. Napabucasin downregulates stemness gene expression driven by Stat3 and cancer stemness properties, and effectively inhibits self-renewal of stemness-high cancer cells with IC50 ranged from 0.291~1.19 μM, on inhibition on normal stem cells. In vivo In mice bearing PaCa-2 xenografts, Napabucasin (20 mg/kg, i.p.) significantly inhibits tumor growth, relapse and metastasis. cell lines： Concentrations：~2 μM Incubation Time：72 h Powder Purity:≥99% |
| Canonical SMILES | CC(=O)C1=CC2=C(O1)C(=O)C3=CC=CC=C3C2=O |
|---|---|
| Molecular Weight | 240.21 |
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| Solubility | Solubility (25°C) In vitro DMSO: 62 mg/mL (199.08 mM); Water: Insoluble; Ethanol: Insoluble; |
|---|
