NAS-181 - 97%, high purity , CAS No.1217474-40-2

Item Number

N288858

Grouped product items
SKU	Size	Availability	Price
N288858-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$119.90
N288858-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$399.90
N288858-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$629.90
N288858-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,259.90
N288858-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,019.90

Selective r5-HT1Bantagonist; activein vivo

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Basic Description

Synonyms	SR-01000597970 \| NAS-181 dimesylate \| (2R)-2-[[[3-(4-Morpholinylmethyl)-2H-1-benzopyran-8-yl]oxy]methyl]morpholine dimethanesulfonate \| 1217474-40-2 \| NAS-181 (dimesylate) \| MS-29936 \| SR-01000597970-1 \| HY-103156 \| CS-0024691 \| methanesulfonic acid;(2R)-
Specifications & Purity	≥97%
Biochemical and Physiological Mechanisms	Potent, selective antagonist at the rat 5-HT1Breceptor (Ki= 47 nM). Increases synthesis and metabolism of 5-HT in the brain following systemic administration and improves passive avoidance retention performancein vivo. Increases subthalamic nucleus-trigge
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	NAS181 is a potent and selective antagonist of rat 5-HT1B receptor, with a Ki of 47 nM. NAS181 shows 13-fold selectivity for r5-HT1B over bovine 5-HT1B receptor (Ki=630 nM). NAS181 increases the 5-HT turnover and the synaptic concentration of 5-HT by inhibiting terminal r5-HT1B autoreceptors.

Names and Identifiers

IUPAC Name	methanesulfonic acid;(2R)-2-[[3-(morpholin-4-ylmethyl)-2H-chromen-8-yl]oxymethyl]morpholine
INCHI	InChI=1S/C19H26N2O4.2CH4O3S/c1-2-16-10-15(12-21-5-8-22-9-6-21)13-25-19(16)18(3-1)24-14-17-11-20-4-7-23-17;21-5(2,3)4/h1-3,10,17,20H,4-9,11-14H2;21H3,(H,2,3,4)/t17-;;/m1../s1
InChi Key	WMRMIRRDPBKNMY-ZEECNFPPSA-N
Canonical SMILES	CS(=O)(=O)O.CS(=O)(=O)O.C1COC(CN1)COC2=CC=CC3=C2OCC(=C3)CN4CCOCC4
Isomeric SMILES	CS(=O)(=O)O.CS(=O)(=O)O.C1CO[C@H](CN1)COC2=CC=CC3=C2OCC(=C3)CN4CCOCC4
PubChem CID	45073445
Molecular Weight	538.63

Solubility

Solvent:water, Max Conc. mg/mL: 53.86, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 53.86, Max Conc. mM: 100

Sensitivity

Moisture sensitive

Solution Calculators

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Basic Description