My Cart
You have no items in your shopping cart.
SKU | Size | Availability | Price | Qty |
---|---|---|---|---|
N288858-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $119.90 | |
N288858-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $399.90 | |
N288858-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $629.90 | |
N288858-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,259.90 | |
N288858-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,019.90 |
Selective r5-HT1Bantagonist; activein vivo
Synonyms | SR-01000597970 | NAS-181 dimesylate | (2R)-2-[[[3-(4-Morpholinylmethyl)-2H-1-benzopyran-8-yl]oxy]methyl]morpholine dimethanesulfonate | 1217474-40-2 | NAS-181 (dimesylate) | MS-29936 | SR-01000597970-1 | HY-103156 | CS-0024691 | methanesulfonic acid;(2R)- |
---|---|
Specifications & Purity | ≥97% |
Biochemical and Physiological Mechanisms | Potent, selective antagonist at the rat 5-HT1Breceptor (Ki= 47 nM). Increases synthesis and metabolism of 5-HT in the brain following systemic administration and improves passive avoidance retention performancein vivo. Increases subthalamic nucleus-trigge |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Product Description | NAS181 is a potent and selective antagonist of rat 5-HT1B receptor, with a Ki of 47 nM. NAS181 shows 13-fold selectivity for r5-HT1B over bovine 5-HT1B receptor (Ki=630 nM). NAS181 increases the 5-HT turnover and the synaptic concentration of 5-HT by inhibiting terminal r5-HT1B autoreceptors. |
IUPAC Name | methanesulfonic acid;(2R)-2-[[3-(morpholin-4-ylmethyl)-2H-chromen-8-yl]oxymethyl]morpholine |
---|---|
INCHI | InChI=1S/C19H26N2O4.2CH4O3S/c1-2-16-10-15(12-21-5-8-22-9-6-21)13-25-19(16)18(3-1)24-14-17-11-20-4-7-23-17;2*1-5(2,3)4/h1-3,10,17,20H,4-9,11-14H2;2*1H3,(H,2,3,4)/t17-;;/m1../s1 |
InChi Key | WMRMIRRDPBKNMY-ZEECNFPPSA-N |
Canonical SMILES | CS(=O)(=O)O.CS(=O)(=O)O.C1COC(CN1)COC2=CC=CC3=C2OCC(=C3)CN4CCOCC4 |
Isomeric SMILES | CS(=O)(=O)O.CS(=O)(=O)O.C1CO[C@H](CN1)COC2=CC=CC3=C2OCC(=C3)CN4CCOCC4 |
PubChem CID | 45073445 |
Molecular Weight | 538.63 |
Solubility | Solvent:water, Max Conc. mg/mL: 53.86, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 53.86, Max Conc. mM: 100 |
---|---|
Sensitivity | Moisture sensitive |