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Navarixin (SCH-527123) - 10mM in DMSO, high purity , CAS No.473727-83-2
Basic Description Specifications & Purity Moligand™, 10mM in DMSO Biochemical and Physiological Mechanisms Navarixin (SCH-527123, MK-7123, PS-291822) is a potent, orally bioavailable CXCR2/CXCR1 antagonist with IC50 values of 2.6 nM and 36 nM, respectively. Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Grade Moligand™ Product Description Information
Navarixin (SCH-527123) Navarixin (SCH-527123, MK-7123, PS-291822) is a potent, orally bioavailable CXCR2/CXCR1 antagonist with IC50 values of 2.6 nM and 36 nM, respectively.
Targets
CXCR2 (Cell-free assay); CXCR1 (Cell-free assay) 2.6 nM; 36 nM
Product Properties ALogP 1.635 HBD Count 3 Rotatable Bond 7
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name 2-hydroxy-N,N-dimethyl-3-[[2-[[(1R)-1-(5-methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobuten-1-yl]amino]benzamide INCHI InChI=1S/C21H23N3O5/c1-5-13(15-10-9-11(2)29-15)22-16-17(20(27)19(16)26)23-14-8-6-7-12(18(14)25)21(28)24(3)4/h6-10,13,22-23,25H,5H2,1-4H3/t13-/m1/s1 InChi Key RXIUEIPPLAFSDF-CYBMUJFWSA-N Canonical SMILES CCC(C1=CC=C(O1)C)NC2=C(C(=O)C2=O)NC3=CC=CC(=C3O)C(=O)N(C)C Isomeric SMILES CC[C@H](C1=CC=C(O1)C)NC2=C(C(=O)C2=O)NC3=CC=CC(=C3O)C(=O)N(C)C PubChem CID 9865554 Molecular Weight 397.42
Chemical and Physical Properties DMSO(mg / mL) Max Solubility 79 DMSO(mM) Max Solubility 198.78214483418 Water(mg / mL) Max Solubility ＜1
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