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NBI-921352 , CAS No.N612180, Inhibitor of Na v1.6

Item Number

N612180

Grouped product items
SKU	Size	Availability	Price	Qty
N612180-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$283.90
N612180-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$947.90

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Basic Description

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IUPAC Name	(3R)-1-benzyl-N-{5-fluoro-2-methyl-4-[(1,3-thiazol-4-yl)methanesulfonyl]phenyl}-N-methylpyrrolidin-3-amine
INCHI	InChI=1S/C23H26FN3O2S2/c1-17-10-23(31(28,29)15-19-14-30-16-25-19)21(24)11-22(17)26(2)20-8-9-27(13-20)12-18-6-4-3-5-7-18/h3-7,10-11,14,16,20H,8-9,12-13,15H2,1-2H3/t20-/m1/s1
InChi Key	NCHSBJMSORBEAV-HXUWFJFHSA-N
Canonical SMILES	CN([C@@H]1CCN(Cc2ccccc2)C1)c1c(C)cc(c(F)c1)S(=O)(=O)Cc1cscn1
PubChem CID	162366966

PubChem CID	162366966

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1. Johnson JP, Focken T, Khakh K, Tari PK, Dube C, Goodchild SJ, Andrez JC, Bankar G, Bogucki D, Burford K et al.. (2022) NBI-921352, a first-in-class, Na_V1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats.. Elife, 11 (3): (e72468). [PMID:35234610]
2. Bialer M, Johannessen SI, Koepp MJ, Levy RH, Perucca E, Tomson T, White HS. (2018) Progress report on new antiepileptic drugs: A summary of the Fourteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIV). I. Drugs in preclinical and early clinical development.. Epilepsia, 59 (10): (1811-1841). [PMID:30368792]

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