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Nebularine - ≥98%, high purity , CAS No.550-33-4
Basic Description Synonyms Nebularine|550-33-4|Purine riboside|Purine ribonucleoside|Purine nucleoside|N-D-Ribosylpurine|Purine, ribosyl-|Isopurine, ribosyl-|(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol|9-(beta-D-Ribofuranosyl)purine|B8B604PS4P|9-beta-R Specifications & Purity ≥98% Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description Nebularine is a naturally occurring nucleoside, which inhibits mouse Sarcoma 180 and mycobacteria. Studies indicate that Nebularine functions by inhibiting enzymes such as adenine deaminase. In addition, Nebularine can be used to analyze structure determinants of DNA that are recognized by DNA repair enzymes. These studies show that Nebularine can also be used to locate triple helices at G-C sequences. Nebularine can act as a universal base, which can bind to all four of the nucleosides of DNA, with a greater tendency binding to Thymine. Furthermore, Nebularine cellular uptake in mice can be reduced by the nucleoside transport inhibitor, nitrobenzylthioinosine.
Product Properties pKa pKa: 13.13 (Predicted), pKa: 2.42 (Predicted)
Names and Identifiers IUPAC Name (2R,3S,4R,5R)-2-(hydroxymethyl)-5-purin-9-yloxolane-3,4-diol INCHI InChI=1S/C10H12N4O4/c15-2-6-7(16)8(17)10(18-6)14-4-13-5-1-11-3-12-9(5)14/h1,3-4,6-8,10,15-17H,2H2/t6-,7-,8-,10-/m1/s1 InChi Key MRWXACSTFXYYMV-FDDDBJFASA-N Canonical SMILES C1=C2C(=NC=N1)N(C=N2)C3C(C(C(O3)CO)O)O Isomeric SMILES C1=C2C(=NC=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O RTECS UO9100000 PubChem CID 68368 Molecular Weight 252.23
Chemical and Physical Properties Solubility Soluble in Ethanol and Methanol Refractive Index n20D1.84 (Predicted) Specific Rotation[α] α20/D -56 – -46°±2°, c = 1 in water Boil Point(°C) 591.56° C at 760 mmHg (Predicted) Melt Point(°C) 173-175° C
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
RTECS UO9100000 Merck Index 5.02847222222222
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