NecroIr1 - 98%, high purity , CAS No.N658924

Item Number

N658924

Grouped product items
SKU	Size	Availability	Price	Qty
N658924-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$450.90
N658924-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$800.90

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Basic Description

Specifications & Purity	98%
Storage Temp	Store at 2-8°C,Desiccated
Shipped In	Wet ice
Product Description	NecroIr1 is an iridium(III) complex, serves as necroptosis inducers in Cisplatin ( HY-17394 )-resistant lung cancer cells (A549R). NecroIr1 selectively accumulates in mitochondria, leading to oxidative stress and loss of mitochondrial membrane potential ( Appearance:Solid IC50& Target:CDK4 RIPK3 RIPK1 In Vitro:NecroIr1 (2 μM; 1-2 d) exerts subcellular distribution over 90% accumulated in mitochondria in non-labelled A549R and CFSElabelled L02 cells. NecroIr1 (1.5 μM and 3 μM; 24 h) results ROS generation increasing and loss of mitochondrial membrane potent Biological Activity:NecroIr1 is an iridium(III) complex, serves as necroptosis inducers in Cisplatin ( HY-17394 )-resistant lung cancer cells (A549R). NecroIr1 selectively accumulates in mitochondria, leading to oxidative stress and loss of mitochondrial membrane potential (

Canonical SMILES

CC1=CC(C2=[N]3C=CC(C4=NC(C=CC=C5)=C5O4)=C2)=[N]([Ir]67([N]8=CC=CC=C8C9=C7C=CC=C9)3[N]%10=CC=CC=C%10C%11=C6C=CC=C%11)C=C1.[+].[Cl-]

Molecular Weight

823.36

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Basic Description