Nedisertib (M3814) - 99%, high purity , CAS No.1637542-33-6, Inhibitor of protein kinase; DNA-activated; catalytic subunit

Item Number

N414073

Grouped product items
SKU	Size	Availability	Price
N414073-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,180.90
N414073-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,303.90
N414073-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$738.90
N414073-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,116.90

DNA-PK Inhibitors

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Basic Description

Synonyms	nedisertib\|peposertib\|1637542-33-6\|M3814\|MSC2490484A\|M-3814\|M-3814(nedisertib)\|MSC-2490484A\|GN429E725A\|(S)-[2-chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)phenyl]-(6-methoxypyridazin-3-yl)methanol\|(~{S})-[2-chloranyl-4-fluoranyl-5-(7-morpholin-4-ylq
Specifications & Purity	99%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of protein kinase; DNA-activated; catalytic subunit

Names and Identifiers

IUPAC Name	(S)-[2-chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)phenyl]-(6-methoxypyridazin-3-yl)methanol
INCHI	InChI=1S/C24H21ClFN5O3/c1-33-22-5-4-20(29-30-22)24(32)16-11-17(19(26)12-18(16)25)23-15-3-2-14(10-21(15)27-13-28-23)31-6-8-34-9-7-31/h2-5,10-13,24,32H,6-9H2,1H3/t24-/m0/s1
InChi Key	MOWXJLUYGFNTAL-DEOSSOPVSA-N
Canonical SMILES	COC1=NN=C(C=C1)C(C2=C(C=C(C(=C2)C3=NC=NC4=C3C=CC(=C4)N5CCOCC5)F)Cl)O
Isomeric SMILES	COC1=NN=C(C=C1)[C@H](C2=C(C=C(C(=C2)C3=NC=NC4=C3C=CC(=C4)N5CCOCC5)F)Cl)O
PubChem CID	86292849
Molecular Weight	481.91

PubChem CID

CAS Registry No.

RCSB PDB Ligand

Certificates

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7 results found

Lot Number	Certificate Type	Date	Item
L2315412	Certificate of Analysis	Dec 02, 2023	N414073
L2315413	Certificate of Analysis	Dec 02, 2023	N414073
L2315414	Certificate of Analysis	Dec 02, 2023	N414073
L2315415	Certificate of Analysis	Dec 02, 2023	N414073
L2315416	Certificate of Analysis	Dec 02, 2023	N414073
L2315417	Certificate of Analysis	Dec 02, 2023	N414073
L2315418	Certificate of Analysis	Dec 02, 2023	N414073

References

1. Harnor SJ, Brennan A, Cano C. (2017) Targeting DNA-Dependent Protein Kinase for Cancer Therapy.. ChemMedChem, 12 (12): (895-900). [PMID:28423228]
2. Klein C, Dokic I, Mairani A, Mein S, Brons S, Häring P, Haberer T, Jäkel O, Zimmermann A, Zenke F et al.. (2017) Overcoming hypoxia-induced tumor radioresistance in non-small cell lung cancer by targeting DNA-dependent protein kinase in combination with carbon ion irradiation.. Radiat Oncol, 12 (1): (208). [PMID:29287602]

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Basic Description