Grouped product items

SKU

Size

Availability

Price

Qty

N141402-250mg

250mg

In stock

$87.90

N141402-1g

In stock

$269.90

N141402-5g

In stock

$1,214.90

N141402-10g

10g

Available within 4-8 weeks(?)

$2,185.90

Basic Description

Synonyms	AMY22585 \| BCP28714 \| cis-15-Tetracosenate \| UNII-91OQS788BE \| FA 24:1 \| Nervonic acid \| SCHEMBL21103 \| FA(24:1) \| (15e)-Tetracos-15-Enoic Acid \| (15Z)-tetracos-15-enoic acid \| 91OQS788BE \| C08323 \| selacholeate \| 15-TETRACOSENOIC ACID, CIS- \| Nervonic ac
Specifications & Purity	≥95%(GC)
Biochemical and Physiological Mechanisms	Nervonic acid (C24:1), a component of membrane sphingolipids and phosphatidylethanolamines, may be a useful predictor of chronic kidney disease mortality and diabetes. Nervonic acid oils are being studied for pharmaceutical, nutraceutical and industrial a
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Nervonic acid has been used as a synthetic lipid supplement in vitro to study about effect of the developmental diet in Drosophila lifespan.

Names and Identifiers

IUPAC Name	(Z)-tetracos-15-enoic acid
INCHI	InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/b10-9-
InChi Key	GWHCXVQVJPWHRF-KTKRTIGZSA-N
Canonical SMILES	CCCCCCCCC=CCCCCCCCCCCCCCC(=O)O
Isomeric SMILES	CCCCCCCC/C=C\CCCCCCCCCCCCCC(=O)O
WGK Germany	3
PubChem CID	5281120
Molecular Weight	366.62
Beilstein	1728551

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number	Certificate Type	Date	Item
K2321177	Certificate of Analysis	Feb 23, 2023	N141402
K2321526	Certificate of Analysis	Feb 23, 2023	N141402
K2321527	Certificate of Analysis	Feb 23, 2023	N141402
K2321537	Certificate of Analysis	Feb 23, 2023	N141402
D2222135	Certificate of Analysis	Apr 30, 2022	N141402
D2222136	Certificate of Analysis	Apr 30, 2022	N141402
B2208440	Certificate of Analysis	Dec 20, 2021	N141402
B2208445	Certificate of Analysis	Dec 20, 2021	N141402
B2208504	Certificate of Analysis	Dec 20, 2021	N141402
B2208505	Certificate of Analysis	Dec 20, 2021	N141402

Chemical and Physical Properties

Solubility	Insoluble in water；DMSO：79 mg/mL；Ethanol：79 mg/mL
Sensitivity	air sensitive；light sensitive
Flash Point(°F)	110 °C
Flash Point(°C)	110°C
Melt Point(°C)	42-43°C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3

Citations of This Product

1. Jie Cheng, Yuling Li, Yunjun Wang, Jing Zhang, Tuanqi Sun, Li Zhang, Yinlong Guo. (2022) Quaterization Derivatization with Bis(Pyridine) Iodine Tetrafluoroboride: High-Sensitivity Mass Spectrometric Analysis of Unsaturated Fatty Acids in Human Thyroid Tissues. ANALYTICAL CHEMISTRY, 94 (32): (11185–11191). [PMID:35916214]

References

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2. Inderjit Singh. (2002-07-20) Peroxisomal fatty acid oxidation and cellular redox.. Methods in enzymology, 352 (361-372). [PMID:12125363]
3. Nobuyuki Kasai,Yoshiyuki Mizushina,Fumio Sugawara,Kengo Sakaguchi. (2002-11-06) Three-dimensional structural model analysis of the binding site of an inhibitor, nervonic acid, of both DNA polymerase beta and HIV-1 reverse transcriptase.. Journal of biochemistry, 132 ((5)): (819-828). [PMID:12417034]
4. Marie-Elisabeth Agazzi,Andrea Bau,Robertino Barcarolo,Ernst Luecker,Josefa Barrero-Moreno,Elke Anklam. (2003-05-07) In-house validation of an improved sample extraction and clean-up method for GC determination of isomers of nervonic acid in meat products.. Analytical and bioanalytical chemistry, 376 ((3)): (360-365). [PMID:12732919]
5. William J Bettger,Edith DiMichelle-Ranalli,Barbara Dillingham,Clarke B Blackadar. (2003-05-14) Nervonic acid is transferred from the maternal diet to milk and tissues of suckling rat pups.. The Journal of nutritional biochemistry, 14 ((3)): (160-165). [PMID:12742544]
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7. Aleix Sala-Vila,Ana I Castellote,Cristina Campoy,Montserrat Rivero,María Rodriguez-Palmero,M Carmen López-Sabater. (2004-03-31) The source of long-chain PUFA in formula supplements does not affect the fatty acid composition of plasma lipids in full-term infants.. The Journal of nutrition, 134 ((4)): (868-873). [PMID:15051839]
8. Ann M Findley,Earl H Weidner,Kevin R Carman,Zhimin Xu,J Samuel Godbar. (2005-07-12) Role of the posterior vacuole in Spraguea lophii (Microsporidia) spore hatching.. Folia parasitologica, 52 ((1-2)): (111-117). [PMID:16004370]
9. Nobuyuki Kasai,Yoshiyuki Mizushina,Hiroshi Murata,Takayuki Yamazaki,Tadayasu Ohkubo,Kengo Sakaguchi,Fumio Sugawara. (2005-09-01) Sulfoquinovosylmonoacylglycerol inhibitory mode analysis of rat DNA polymerase beta.. The FEBS journal, 272 ((17)): (4349-4361). [PMID:16128805]
10. Eiji Oda,Katsuharu Hatada,Jun Kimura,Yoshifusa Aizawa,Punniyakoti Veeraveedu Thanikachalam,Kenichi Watanabe. (2006-01-06) Relationships between serum unsaturated fatty acids and coronary risk factors: negative relations between nervonic acid and obesity-related risk factors.. International heart journal, 46 ((6)): (975-985). [PMID:16394593]
11. M Laasonen,A T Erkkilä,E Isotalo,P K Mäenpää,J J Pulkkinen,V Virsu,M-L Haapanen. (2006-03-21) Serum lipid fatty acids and temporal processing acuity in children with oral clefts.. Prostaglandins, leukotrienes, and essential fatty acids, 74 ((4)): (263-270). [PMID:16545557]
12. B Singh,B K Chandan,N Sharma,V Bhardwaj,N K Satti,V N Gupta,B D Gupta,K A Suri,O P Suri. (2006-07-15) Isolation, structure elucidation and in vivo hepatoprotective potential of trans-tetracos-15-enoic acid from Indigofera tinctoria Linn.. Phytotherapy research : PTR, 20 ((10)): (831-839). [PMID:16841368]
13. Martin Karlsson,Staffan Mårild,John Brandberg,Lars Lönn,Peter Friberg,Birgitta Strandvik. (2006-12-01) Serum phospholipid fatty acids, adipose tissue, and metabolic markers in obese adolescents.. Obesity (Silver Spring, Md.), 14 ((11)): (1931-1939). [PMID:17135608]
14. Yiming Guo,Elzbieta Mietkiewska,Tammy Francis,Vesna Katavic,Jennifer M Brost,Michael Giblin,Dennis L Barton,David C Taylor. (2008-12-17) Increase in nervonic acid content in transformed yeast and transgenic plants by introduction of a Lunaria annua L. 3-ketoacyl-CoA synthase (KCS) gene.. Plant molecular biology, 69 ((5)): (565-575). [PMID:19082744]
15. Jun Yang,Jing Yang,Zheng-Qin Yin,Jing Xu,Ning Hu,I Svir,Min Wang,Yuan-Yi Li,Lei Zhan,Song Wu,Xiao-Lin Zheng. (2009-09-15) Study of the inhibitory effect of fatty acids on the interaction between DNA and polymerase beta.. Biochemistry. Biokhimiia, 74 ((7)): (813-818). [PMID:19747104]
16. Aurore Vluggens,Pierre Andreoletti,Navin Viswakarma,Yuzhi Jia,Kojiro Matsumoto,Wim Kulik,Mushfiquddin Khan,Jiansheng Huang,Dongsheng Guo,Sangtao Yu,Joy Sarkar,Inderjit Singh,M Sambasiva Rao,Ronald J Wanders,Janardan K Reddy,Mustapha Cherkaoui-Malki. (2010-03-03) Reversal of mouse Acyl-CoA oxidase 1 (ACOX1) null phenotype by human ACOX1b isoform [corrected].. Laboratory investigation; a journal of technical methods and pathology, 90 ((5)): (696-708). [PMID:20195242]
17. Yunbao Liu,Muraleedharan G Nair. (2010-06-23) An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds.. Journal of natural products, 73 ((7)): (1193-1195). [PMID:20565070]
18. Oswald Quehenberger,Aaron M Armando,Alex H Brown,Stephen B Milne,David S Myers,Alfred H Merrill,Sibali Bandyopadhyay,Kristin N Jones,Samuel Kelly,Rebecca L Shaner,Cameron M Sullards,Elaine Wang,Robert C Murphy,Robert M Barkley,Thomas J Leiker,Christian R H Raetz,Ziqiang Guan,Gregory M Laird,David A Six,David W Russell,Jeffrey G McDonald,Shankar Subramaniam,Eoin Fahy,Edward A Dennis. (2010-07-31) Lipidomics reveals a remarkable diversity of lipids in human plasma.. Journal of lipid research, 51 ((11)): (3299-3305). [PMID:20671299]
19. Giuseppe Impallomeni,Alberto Ballistreri,Giovanni Marco Carnemolla,Salvatore P P Guglielmino,Marco Sebastiano Nicolò,Maria Grazia Cambria. (2010-11-03) Synthesis and characterization of poly(3-hydroxyalkanoates) from Brassica carinata oil with high content of erucic acid and from very long chain fatty acids.. International journal of biological macromolecules, 48 ((1)): (137-145). [PMID:21035502]
20. Gregory C Shearer,Juan J Carrero,Olof Heimbürger,Peter Barany,Peter Stenvinkel. (2011-07-22) Plasma fatty acids in chronic kidney disease: nervonic acid predicts mortality.. Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 22 ((2)): (277-283). [PMID:21775161]
21. Madhavi V Dhobale,Nisha Wadhwani,Savita S Mehendale,Hemlata R Pisal,Sadhana R Joshi. (2011-08-06) Reduced levels of placental long chain polyunsaturated fatty acids in preterm deliveries.. Prostaglandins, leukotrienes, and essential fatty acids, 85 ((3-4)): (149-153). [PMID:21816593]
22. G P Amminger,M R Schäfer,C M Klier,J-M Slavik,I Holzer,M Holub,S Goldstone,T J Whitford,P D McGorry,M Berk. (2011-12-21) Decreased nervonic acid levels in erythrocyte membranes predict psychosis in help-seeking ultra-high-risk individuals.. Molecular psychiatry, 17 ((12)): (1150-1152). [PMID:22182937]
23. S Snigdha,G Astarita,D Piomelli,C W Cotman. (2011-12-21) Effects of diet and behavioral enrichment on free fatty acids in the aged canine brain.. Neuroscience, 202 (326-333). [PMID:22183056]
24. Dong Chang,Shengzhong Rong,Yannan Zhang,Qian Sha,Meihua Liang,Xuefei Zhang,Miaojing Li,Hongzhi Pan. (2014-08-01) Serum free fatty acids level in senile cataract.. Journal of the American College of Nutrition, 33 ((5)): (406-411). [PMID:25079310]
25. J R Sargent,K Coupland,R Wilson. (1994-04-01) Nervonic acid and demyelinating disease.. Medical hypotheses, 42 ((4)): (237-242). [PMID:8072429]
26. L Zhou,J Hou,H Fan. (2003-01-29) [Determination of nervonic acid in oral tonic by GC].. Se pu = Chinese journal of chromatography, 17 ((3)): (306-307). [PMID:12549137]
27. Arja T Erkkilä,Elina Isotalo,Joonas Pulkkinen,Marja-Leena Haapanen. (2005-09-30) Association between school performance, breast milk intake and fatty acid profile of serum lipids in ten-year-old cleft children.. The Journal of craniofacial surgery, 16 ((5)): (764-769). [PMID:16192854]
28. Shizuka Murakami,Shinji Kamisuki,Kei-ichi Takata,Nobuyuki Kasai,Seisuke Kimura,Yoshiyuki Mizushina,Keisuke Ohta,Fumio Sugawara,Kengo Sakaguchi. (2006-09-26) Site-directed mutational analysis of structural interactions of low molecule compounds binding to the N-terminal 8 kDa domain of DNA polymerase beta.. Biochemical and biophysical research communications, 350 ((1)): (7-16). [PMID:16996474]
29. Todd E Fox,Maria C Bewley,Kellee A Unrath,Michelle M Pedersen,Robert E Anderson,Dae Young Jung,Leonard S Jefferson,Jason K Kim,Sarah K Bronson,John M Flanagan,Mark Kester. (2010-11-12) Circulating sphingolipid biomarkers in models of type 1 diabetes.. Journal of lipid research, 52 ((3)): (509-517). [PMID:21068007]
30. Jie Cheng, Yuling Li, Yunjun Wang, Jing Zhang, Tuanqi Sun, Li Zhang, Yinlong Guo. (2022) Quaterization Derivatization with Bis(Pyridine) Iodine Tetrafluoroboride: High-Sensitivity Mass Spectrometric Analysis of Unsaturated Fatty Acids in Human Thyroid Tissues. ANALYTICAL CHEMISTRY, 94 (32): (11185–11191). [PMID:35916214]

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Nervonic acid - ≥95.0%(GC), high purity , CAS No.506-37-6

Basic Description

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator