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NG25 - ≥98%, high purity , CAS No.1315355-93-1, Inhibitor of C-terminal Src kinase;Inhibitor of LYN proto-oncogene; Src family tyrosine kinase;Inhibitor of mitogen-activated protein kinase kinase kinase 7;Inhibitor of mitogen-activated protein kinase kinase kinase kinase 2;Inhibitor of SRC proto-oncoge

Moligand™
≥98%

CAS#: 1315355-93-1
Formula: C₂₉H₃₀F₃N₅O₂
Molecular Weight: 537.58
PubChem CID: 53340664

Item Number

N125272

Grouped product items
SKU	Size	Availability	Price
N125272-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$286.90
N125272-10mg	10mg	In stock	$508.90
N125272-25mg	25mg	In stock	$1,145.90
N125272-100mg	100mg	In stock	$4,122.90

TGF-β-activated kinase (TAK1) inhibitor

View related series

C-terminal Src kinase Inhibitor LYN proto-oncogene，Src family tyrosine kinase Inhibitor mitogen-activated protein kinase kinase kinase 7 Inhibitor mitogen-activated protein kinase kinase kinase kinase 2 Inhibitor SRC proto-oncogene，non-receptor tyrosine kinase Inhibitor

Basic Description

Synonyms	NG25\|1315355-93-1\|N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide\|NG-25\|Benzamide, N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	TGF-β-activated kinase (TAK1) inhibitor (IC50= 149 nM). Also inhibits LYN, MAP4K2 and Abl kinase activity (IC50values are 12.9, 21.7 and 75.2 nM, respectively). Suppresses CpG A and CpG B-stimulated secretion of IFN-αand TLR7/8 agonist CL097-stimulated se
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of C-terminal Src kinase;Inhibitor of LYN proto-oncogene; Src family tyrosine kinase;Inhibitor of mitogen-activated protein kinase kinase kinase 7;Inhibitor of mitogen-activated protein kinase kinase kinase kinase 2;Inhibitor of SRC proto-oncoge

Associated Targets

CSK Tchem Tyrosine-protein kinase CSK 1 Activities

Discover Target: CSK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SRC Tclin Proto-oncogene tyrosine-protein kinase Src 1 Activities

Discover Target: SRC

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FLT3 Tclin Receptor-type tyrosine-protein kinase FLT3 0 Activities

Discover Target: FLT3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FES Tclin Tyrosine-protein kinase Fes/Fps 0 Activities

Discover Target: FES

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAP4K2 Tchem Mitogen-activated protein kinase kinase kinase kinase 2 1 Activities

Discover Target: MAP4K2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAP3K7 Tchem Mitogen-activated protein kinase kinase kinase 7 1 Activities

Discover Target: MAP3K7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LYN Tclin Tyrosine-protein kinase Lyn 1 Activities

Discover Target: LYN

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide
INCHI	InChI=1S/C29H30F3N5O2/c1-3-36-12-14-37(15-13-36)18-21-6-7-22(17-24(21)29(30,31)32)35-28(38)20-5-4-19(2)26(16-20)39-25-9-11-34-27-23(25)8-10-33-27/h4-11,16-17H,3,12-15,18H2,1-2H3,(H,33,34)(H,35,38)
InChi Key	SMPGEBOIKULBCT-UHFFFAOYSA-N
Canonical SMILES	CCN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)C3=CC(=C(C=C3)C)OC4=C5C=CNC5=NC=C4)C(F)(F)F
Isomeric SMILES	CCN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)C3=CC(=C(C=C3)C)OC4=C5C=CNC5=NC=C4)C(F)(F)F
PubChem CID	53340664
Molecular Weight	537.58

PubChem CID

53340664

CAS Registry No.

1315355-93-1

RCSB PDB Ligand

NG2

Certificates

Certificate of Analysis(COA)

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4 results found

Lot Number	Certificate Type	Date	Item
I2220514	Certificate of Analysis	Jul 11, 2024	N125272
I2220519	Certificate of Analysis	Jul 11, 2024	N125272
I2220521	Certificate of Analysis	Jul 02, 2024	N125272
I2220520	Certificate of Analysis	Jul 13, 2022	N125272

Solubility

Solvent:DMSO, Max Conc. mg/mL: 10.75, Max Conc. mM: 20

Sensitivity

Light sensitive

References

1. Tan L, Nomanbhoy T, Gurbani D, Patricelli M, Hunter J, Geng J, Herhaus L, Zhang J, Pauls E, Ham Y et al.. (2015) Discovery of Type II Inhibitors of TGFβ-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2).. J Med Chem, 58 (1): (183-96). [PMID:25075558]
2. Meng F, Li Y, Tian X, Fu L, Yin Y, Sui C, Ma P, Jiang Y. (2014) Identification of TGF-β-activated kinase 1 as a possible novel target for renal cell carcinoma intervention.. Biochem Biophys Res Commun, 453 (1): (106-11). [PMID:25261726]

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