NGM120 (anti-GFRAL) - Primary antibody, specific to GFRAL, >95%, high purity, Human IgG1

Features and benefits

Short Overview:
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
Species reactivity(Reacts with): Human
Isotype: Human IgG1

Application:

Item Number

Ab177922

Grouped product items
SKU	Size	Availability	Price
Ab177922-100μg	100μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$109.90
Ab177922-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$519.90
Ab177922-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,399.90
Ab177922-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,239.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

View related series

Basic Description

Product Name	NGM120 (anti-GFRAL) - Primary antibody, specific to GFRAL, >95%, high purity, Human IgG1
Synonyms	bA360D14.1 antibody; C6orf144 antibody; GDNF family receptor alpha-like antibody; Gfral antibody; GFRAL_HUMAN antibody; GRAL antibody; IVFI9356 antibody; UNQ9356 antibody; UNQ9356/PRO34128 antibody; GFR alpha like; GFR alpha-like; GFRAL; GRAL
Specifications & Purity	ExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot
Specificity	GFRAL
Conjugation	Unconjugated
Grade	Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Product Description	NGM120 (anti-GFRAL) is a long-acting monoclonal antibody directed against glial-cell-derived neurotrophic factor (GDNF) family receptor alpha-like (GFRAL), with potential anti-anorexia and anti-cachexia activities. It binds to and blocks GFRAL activity which prevents binding of growth differentiation factor 15 (GDF15; MIC-1) to its receptor GFRAL and prevents GDF15/GFRAL-mediated signaling.

Product Properties

Isotype	Human IgG1
Light Chain Type	kappa
SDS-PAGE	26.5 kDa (Light Chain) & 51.0 kDa (Heavy Chain), under reducing conditions; 195.1 kDa, under non-reducing conditions.
Purification Method	Protein A purified
Purity	>95%
Form	Liquid
Concentration	Lot by Lot
Storage Temp	Store at -80°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.

Certificates

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3 results found

Lot Number	Certificate Type	Date	Item
ZJ24F0404036	Certificate of Analysis	Apr 02, 2024	Ab177922
ZJ24F0404037	Certificate of Analysis	Apr 02, 2024	Ab177922
ZJ24F0404038	Certificate of Analysis	Apr 02, 2024	Ab177922

References

1. Mullican SE, Lin-Schmidt X, Chin CN, Chavez JA, Furman JL, Armstrong AA, Beck SC, South VJ, Dinh TQ, Cash-Mason TD et al.. (2017) GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates.. Nat Med, 23 (10): (1150-1157). [PMID:28846097]
2. Emmerson PJ, Wang F, Du Y, Liu Q, Pickard RT, Gonciarz MD, Coskun T, Hamang MJ, Sindelar DK, Ballman KK et al.. (2017) The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL.. Nat Med, 23 (10): (1215-1219). [PMID:28846098]
3. Yang L, Chang CC, Sun Z, Madsen D, Zhu H, Padkjær SB, Wu X, Huang T, Hultman K, Paulsen SJ et al.. (2017) GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand.. Nat Med, 23 (10): (1158-1166). [PMID:28846099]
4. Hsu, Jer-Yuan JY and 33 more authors.. (2017) Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.. Nature, (12): [PMID:28953886]

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Basic Description