Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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N129566-1g | 1g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $72.90 | |
N129566-5g | 5g | In stock | $214.90 | |
N129566-25g | 25g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $966.90 | |
N129566-100g | 100g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $3,478.90 |
ATP-sensitive K + channel activator
Synonyms | NICORANDIL|65141-46-0|Ikorel|2-Nicotinamidoethyl nitrate|Sigmart|SG-75|Dancor|Nicorandilum|Adancor|2-(pyridine-3-carbonylamino)ethyl nitrate|SG 75|2-(nicotinamido)ethyl nitrate|N-(2-Hydroxyethyl)nicotinamide nitrate|N-(2-Hydroxyethyl)nicotinamide nitrate |
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Specifications & Purity | Moligand™, ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | Nicorandil is a small molecule KATP (Kir6) channel opener, producing relaxation of coronary vascular smooth muscle. Specific binding of Nicorandil to the C-terminus of the SUR2B K(ATP) channel generates K+ flux and hyperpolarization of the surface membran |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ACTIVATOR |
Mechanism of action | Activator of K ir6.1;Activator of K ir6.2 |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | SG-75,Nicorandil has been used as an activator of potassium (K+) channel and inhibitor of voltage-gated calcium channel to study its effects on action potentials in long QT syndrome 2 (LQTS2) human induced pluripotent stem cell (hiPSCs)-derived cardiomyocytes. |
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IUPAC Name | 2-(pyridine-3-carbonylamino)ethyl nitrate |
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INCHI | InChI=1S/C8H9N3O4/c12-8(7-2-1-3-9-6-7)10-4-5-15-11(13)14/h1-3,6H,4-5H2,(H,10,12) |
InChi Key | LBHIOVVIQHSOQN-UHFFFAOYSA-N |
Canonical SMILES | C1=CC(=CN=C1)C(=O)NCCO[N+](=O)[O-] |
Isomeric SMILES | C1=CC(=CN=C1)C(=O)NCCO[N+](=O)[O-] |
WGK Germany | 3 |
RTECS | US4667600 |
PubChem CID | 47528 |
Molecular Weight | 211.17 |
Reaxy-Rn | 481451 |
PubChem CID | 47528 |
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ChEBI | CHEBI:31905 |
Wikipedia | Nicorandil |
ChEMBL Ligand | CHEMBL284906 |
CAS Registry No. | 65141-46-0 |
PEP | nicorandil |
DrugCentral Ligand | 1919 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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K2303368 | Certificate of Analysis | Oct 23, 2023 | N129566 |
K2303369 | Certificate of Analysis | Oct 23, 2023 | N129566 |
K2303370 | Certificate of Analysis | Oct 23, 2023 | N129566 |
K2303451 | Certificate of Analysis | Oct 23, 2023 | N129566 |
H2328031 | Certificate of Analysis | Aug 07, 2023 | N129566 |
K2104028 | Certificate of Analysis | Aug 07, 2023 | N129566 |
K2104177 | Certificate of Analysis | Aug 07, 2023 | N129566 |
K2104249 | Certificate of Analysis | Aug 07, 2023 | N129566 |
K2104517 | Certificate of Analysis | Aug 07, 2023 | N129566 |
Solubility | Soluble in water (4 mg/ml), DMSO (>25 mg/ml), ethanol, ether, and methanol. |
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Sensitivity | Moisture Sensitive |
Melt Point(°C) | 90 °C |
Pictogram(s) | GHS05, GHS07 |
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Signal | Danger |
Hazard Statements | H302:Harmful if swallowed H318:Causes serious eye damage |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P317:Get emergency medical help. |
WGK Germany | 3 |
RTECS | US4667600 |
Reaxy-Rn | 481451 |
Merck Index | 6521 |
1. Nakae I, Matsumoto T, Horie H, Yokohama H, Omura T, Minai K, Matsui T, Nozawa M, Takahashi M, Sugimoto Y et al.. (2000) Effects of intravenous nicorandil on coronary circulation in humans: plasma concentration and action mechanism.. J Cardiovasc Pharmacol, 35 (6): (919-25). [PMID:10836727] |