Nifekalant hydrochloride (MS-551) - ≥98%, high purity , CAS No.130656-51-8

Item Number

N275668

Grouped product items
SKU	Size	Availability	Price
N275668-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$59.90
N275668-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$107.90
N275668-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$243.90
N275668-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$329.90

Voltage-dependent HERG channel blocker

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Basic Description

Synonyms	Nifekalant hydrochloride\|130656-51-8\|nifekalant\|NIFEKALANT HCl\|MS 551\|Nifekalant (hydrochloride)\|MS-551\|130636-43-0\|TPP5R0MDQS\|Shinbit\|6-[2-[2-hydroxyethyl-[3-(4-nitrophenyl)propyl]amino]ethylamino]-1,3-dimethylpyrimidine-2,4-dione;hydrochloride\|DTXCID702
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Nifekalant hydrochloride (MS-551), a class III antiarrhythmic agent, is a IKr potassium channel blocker. Nifekalant hydrochloride can be used for refractory ventricular tachyarrhythmias research.
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	6-[2-[2-hydroxyethyl-[3-(4-nitrophenyl)propyl]amino]ethylamino]-1,3-dimethylpyrimidine-2,4-dione;hydrochloride
INCHI	InChI=1S/C19H27N5O5.ClH/c1-21-17(14-18(26)22(2)19(21)27)20-9-11-23(12-13-25)10-3-4-15-5-7-16(8-6-15)24(28)29;/h5-8,14,20,25H,3-4,9-13H2,1-2H3;1H
InChi Key	YPVGGQKNWAKOPX-UHFFFAOYSA-N
Canonical SMILES	CN1C(=CC(=O)N(C1=O)C)NCCN(CCCC2=CC=C(C=C2)[N+](=O)[O-])CCO.Cl
Isomeric SMILES	CN1C(=CC(=O)N(C1=O)C)NCCN(CCCC2=CC=C(C=C2)[N+](=O)[O-])CCO.Cl
Alternate CAS	130636-43-0
PubChem CID	122188
Molecular Weight	405.45 (free)

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Basic Description